Glia, Journal Year: 2024, Volume and Issue: 73(3), P. 632 - 656

Published: Oct. 16, 2024

Caenorhabditis elegans and Drosophila melanogaster are powerful experimental models for uncovering fundamental tenets of nervous system organization function. Findings over the last two decades show that molecular cellular features broadly conserved between invertebrates vertebrates, indicating insights derived from invertebrate can inform our understanding glial operating principles across diverse species. In recent years, these model systems have led to exciting discoveries in biology mechanisms glia-neuron interactions. Here, we summarize studies applied current state-of-the-art "-omics" techniques C. D. glia. Coupled with remarkable acceleration pace mechanistic glia indicate also exhibit striking complexity, specificity, heterogeneity. We provide an overview discuss their implications as well emerging questions where well-poised fill critical knowledge gaps biology.

Language: Английский