Different functional alteration in attention‐deficit/hyperactivity disorder across developmental age groups: A meta‐analysis and an independent validation of resting‐state functional connectivity studies DOI Creative Commons
Ningning Liu,

Qianrong Liu,

Ziqi Yang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2022, Volume and Issue: 29(1), P. 60 - 69

Published: Dec. 5, 2022

Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) is a highly complex and heterogeneous disorder. Abnormal brain connectivity in ADHD might be influenced by developmental ages which lead to the lacking of significant spatial convergence across studies. However, patterns mechanisms remain fully uncovered. Methods In present study, we searched PubMed, Scopus, Web Science, Embase for seed‐based whole‐brain resting‐state functional studies published through October 12th, 2020. The seeds meeting inclusion criteria were categorized into cortex group subcortex group, as previous suggested that have different temporal development. Activation likelihood estimation meta‐analysis was performed investigate abnormal age groups (all‐age younger: <12 years, older: ≥12 years). Moreover, reported foci used validation with our independent dataset. Results As studies, scarce results found all‐age group. younger consistently exhibited hyper‐connectivity between parts left middle frontal gyrus, hypo‐connectivity putamen/pallidus/amygdala. Whereas, older (mainly adults) showed right precuneus/sub‐gyral/cingulate gyrus. Besides, cortico‐cortical cortico‐subcortical children, adults verified Conclusion Our study emphasizes importance effects on networks ADHD. Further, proposed play an important role pathophysiology children ADHD, while connections more This work provided potential new insight understand neurodevelopmental possible clinical application

Language: Английский

Puberty Initiates Cascading Relationships Between Neurodevelopmental, Social, and Internalizing Processes Across Adolescence DOI
Jennifer H. Pfeifer, Nicholas B. Allen

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 89(2), P. 99 - 108

Published: Sept. 9, 2020

Language: Английский

Citations

272
Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study DOI Creative Commons
Alexis Brieant, Lucinda M. Sisk, Dylan G. Gee

et al.

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 52, P. 101022 - 101022

Published: Oct. 19, 2021

Adversity exposure is a risk factor for psychopathology, which most frequently onsets during adolescence, and prior research has demonstrated that alterations in cortico-limbic connectivity may account part this association. In sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study (N = 4006), we tested longitudinal structural equation model to examine indirect effect adversity (negative life events) on later psychopathology via changes resting-state functional (rsFC). We also examined potential protective effects parental acceptance. Generally, became more strongly negative between baseline year 2 follow-up, suggesting stronger correlations within these networks reflect mature phenotype. Exposure greater number events was associated with rsFC which, turn, lower internalizing (but not externalizing) symptoms. The symptoms significant. Parental acceptance did moderate association rsFC. Our findings highlight how stressful childhood experiences accelerate neurobiological maturation specific connections, potentially reflecting an adaptive process protects against problems context adversity.

Language: Английский

Citations

57
Age-related differences in resting-state functional connectivity from childhood to adolescence DOI Open Access
Ashley Sanders, Michael P. Harms, Sridhar Kandala

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(11), P. 6928 - 6942

Published: Jan. 11, 2023

Abstract The human brain is active at rest, and spontaneous fluctuations in functional MRI BOLD signals reveal an intrinsic architecture. During childhood adolescence, networks undergo varying patterns of maturation, measures connectivity within between differ as a function age. However, many aspects these developmental (e.g. trajectory shape directionality) remain unresolved. In the present study, we characterised age-related differences within- between-network resting-state (rsFC) integration (i.e. participation coefficient, PC) large cross-sectional sample children adolescents (n = 628) aged 8–21 years from Lifespan Human Connectome Project Development. We found evidence for both linear non-linear cortical, subcortical, cerebellar rsFC, well integration, that varied by Additionally, sex moderated relationship age putamen where males displayed significant increases PC compared with females. Taken together, results provide complex, some systems during development.

Language: Английский

Citations

34
Alterations in pain during adolescence and puberty DOI
Hadas Nahman‐Averbuch, Rui Li, Katelynn E. Boerner

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(4), P. 307 - 317

Published: Feb. 24, 2023

Language: Английский

Citations

24
Goal-directed learning in adolescence: neurocognitive development and contextual influences DOI
Linda Wilbrecht, Juliet Y. Davidow

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 176 - 194

Published: Jan. 23, 2024

Language: Английский

Citations

17
Adolescent-to-adult gains in cognitive flexibility are adaptively supported by reward sensitivity, exploration, and neural variability DOI Creative Commons
Ashley C. Parr, Valerie J. Sydnor, Finnegan J. Calabro

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 58, P. 101399 - 101399

Published: May 10, 2024

Language: Английский

Citations

10
Atypical functional connectome is associated with low reflective functioning in incarcerated adolescents DOI Creative Commons
Mélodie Derome, Larisa Morosan, Patrick Heller

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

While functional neuroimaging studies have reported on the neural correlates of severe antisocial behaviors, such as delinquency, little is known about whole brain resting state connectivity (FC) incarcerated adolescents (IA). The aim present study to identify potential differences in between a group male IA, compared community (CA). second objective investigate relations among FC and psychological factors associated with delinquent namely psychopathic traits (callous unemotional traits, interpersonal problems, impulsivity), socio-cognitive (empathy reflective functioning RF) impairments problems (externalizing, internalizing, attention thought problems). 31 IA 30 CA participated 8 minutes MRI. Network Based Statistics (NBS) was used compare 142 regions two groups. Correlation regressions analysis were performed explore associations self-reported empathy, RF, problems. Compared CA, presented significantly increased distributed subnetwork including medial prefrontal, posterior dorsal cingulate, temporal, occipital regions. Both within across sample, mean correlated lower RF (RF uncertainty). Across higher scores externalizing impulsivity dimension psychopathy. extending characterization our results also provide insights into neurofunctional mechanisms linking low abilities behavior during adolescence.

Language: Английский

Citations

1
Developmental Maturation of the Precuneus as a Functional Core of the Default Mode Network DOI Open Access
Rosa Li,

Amanda V. Utevsky,

Scott A. Huettel

et al.

Journal of Cognitive Neuroscience, Journal Year: 2019, Volume and Issue: 31(10), P. 1506 - 1519

Published: May 21, 2019

Efforts to map the functional architecture of developing human brain have shown that connectivity between and within neural networks changes from childhood adulthood. Although prior work has established adult precuneus distinctively modifies its during task versus rest states [Utevsky, A. V., Smith, D. & Huettel, S. Precuneus is a core default-mode network. Journal Neuroscience, 34, 932–940, 2014], it remains unknown how these patterns emerge over development. Here, we use fMRI data collected at two longitudinal time points 250 participants ages 8 26 years engaging in cognitive tasks resting-state scan. By applying independent component analysis both data, identified three canonical interest—the rest-based default mode network task-based left right frontoparietal (LFPN RFPN, respectively)—which explored for developmental using dual regression analyses. We found systematic state-dependent precuneus, such (compared with rest) resulted greater precuneus–LFPN precuneus–RFPN connectivity, whereas being task) precuneus–default connectivity. These cross-sectional results replicated across points. Finally, used mixed models show degree which distinguishes increases age, due age-related increasing segregation LFPN rest. Our highlight distinct role tracking processing state, manner present throughout strengthened

Language: Английский

Citations

69
Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms DOI
Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2020, Volume and Issue: 6(3), P. 329 - 342

Published: Oct. 7, 2020

Language: Английский

Citations

67
Development of the brain functional connectome follows puberty-dependent nonlinear trajectories DOI Creative Commons
Zeus Gracia-Tabuenca, Martha Beatriz Moreno, Fernando A. Barrios

et al.

NeuroImage, Journal Year: 2021, Volume and Issue: 229, P. 117769 - 117769

Published: Jan. 20, 2021

Adolescence is a developmental period that dramatically impacts body and behavior, with pubertal hormones playing an important role not only in the morphological changes but also brain structure function. Understanding development during adolescence has become priority neuroscience because it coincides onset of many psychiatric behavioral disorders. However, little known about how puberty influences functional connectome. In this study, taking longitudinal human sample typically developing children adolescents (of both sexes), we demonstrate connectome better fits status than chronological age. particular, centrality, segregation, efficiency, integration increase after markers. We found these effects are stronger attention task control networks. Lastly, controlling for effect, showed connectivity between networks related to performance cognitive flexibility. This study points out importance considering nonlinear trends when exploring trajectories, emphasizes impact on organization adolescence.

Language: Английский

Citations

54