White matter abnormalities in paediatric obsessive–compulsive disorder: a systematic review of diffusion tensor imaging studies DOI Creative Commons
Maryam Haghshomar, Peyman Mirghaderi, Parnian Shobeiri

et al.

Brain Imaging and Behavior, Journal Year: 2023, Volume and Issue: 17(3), P. 343 - 366

Published: March 20, 2023

Microstructural alterations in white matter are evident obsessive-compulsive disorder (OCD) both adult and paediatric populations. Paediatric patients go through the process of maturation thus may undergo different pathophysiology than OCD. Findings from studies have been inconsistent, possibly due to their small sample size or heterogeneous The aim this review is provide a comprehensive overview structures correlation with clinical features. Based on PRISMA guidelines, we performed systematic search diffusion tensor imaging that reported fractional anisotropy, mean diffusivity, radial axial diffusivity between healthy controls using voxel-based analysis, tract-based spatial statistics. We identified fifteen relevant studies. Most changes predominantly corpus callosum, cingulum, arcuate fasciculus, uncinate inferior longitudinal superior fronto-occipital corticospinal tract, forceps minor major, cerebellum disorder. These included increased decreased anisotropy tracts. were associated symptoms. Moreover, specific genetic polymorphisms linked cerebellar White widespread OCD patients. often symptoms however there controversies direction some

Language: Английский

Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder DOI
Elizabeth Shephard, Emily Stern, Odile A. van den Heuvel

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 26(9), P. 4583 - 4604

Published: Jan. 7, 2021

Language: Английский

Citations

163
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group DOI
Esther Walton, Fabio Bernardoni, Victoria-Luise Batury

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(9), P. 730 - 738

Published: June 1, 2022

Language: Английский

Citations

85
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression DOI Creative Commons
Sara Larivière, Jessica Royer, Raúl Rodríguez‐Cruces

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 27, 2022

Abstract Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients epilepsy related findings to postmortem gene expression patterns. Brain analysis included 578 adults temporal lobe (TLE), 288 idiopathic generalized (IGE), 1328 healthy controls from 18 centres worldwide. Graph theoretical of revealed increased clustering path length orbitofrontal regions TLE, suggesting a shift towards regularization. Conversely, people IGE showed decreased fronto-temporo-parietal cortices, indicating random configuration. Syndrome-specific topological alterations reflected patterns genes for hippocampal sclerosis TLE IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches specific syndromes.

Language: Английский

Citations

66
Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review DOI Creative Commons
Samuel E. Cooper, Joseph E. Dunsmoor

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 129, P. 75 - 94

Published: July 24, 2021

Language: Английский

Citations

58
ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting‐state and task‐based fMRI data DOI
Lea Waller, Susanne Erk, Elena Pozzi

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 43(9), P. 2727 - 2742

Published: March 19, 2022

Abstract The reproducibility crisis in neuroimaging has led to an increased demand for standardized data processing workflows. Within the ENIGMA consortium, we developed HALFpipe ( H armonized A na l ysis of F unctional MRI pipe line), open‐source, containerized, user‐friendly tool that facilitates reproducible analysis task‐based and resting‐state fMRI through uniform application preprocessing, quality assessment, single‐subject feature extraction, group‐level statistics. It provides state‐of‐the‐art preprocessing using fMRIPrep without requirement input Brain Imaging Data Structure (BIDS) format. extends functionality with additional steps, which include spatial smoothing, grand mean scaling, temporal filtering, confound regression. generates interactive assessment (QA) webpage rate key outputs raw general. features myriad post‐processing functions at individual subject level, including calculation activation, seed‐based connectivity, network‐template (or dual) regression, atlas‐based functional connectivity matrices, regional homogeneity (ReHo), fractional amplitude low‐frequency fluctuations (fALFF), offering support evaluate a combinatorial number or settings one run. Finally, flexible factorial models can be defined mixed‐effects regression group multiple comparison correction. Here, introduce theoretical framework was developed, present overview main pipeline. offers scientific community major advance toward addressing neuroimaging, providing workflow encompasses post‐processing, QA data, while broadening core principles producing results. Instructions code found https://github.com/HALFpipe/HALFpipe .

Language: Английский

Citations

56
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings DOI
Eun‐Jin Cheon, Carrie E. Bearden, Daqiang Sun

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2022, Volume and Issue: 76(5), P. 140 - 161

Published: Feb. 4, 2022

This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder (BD), major depressive (MDD), and 22q11.2 Deletion Syndrome (22q11DS) determined by ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium investigations. We obtained ranked effect sizes for subcortical volumes, regional cortical thickness, surface area, diffusion tensor imaging abnormalities, comparing each of these disorders relative to healthy controls. In addition, studies report on significant associations between metrics disorder-related factors such as symptom severity treatments. Visual comparison size profiles shows that are generally same direction scale with (in order SZ > BD MDD). The 22q11DS, a rare genetic syndrome increases risk psychiatric disorders, appear be much larger than either complex disorders. is consistent idea effects compared common variants. Cortical thickness area 22q11DS psychosis without more similar those MDD; pattern not observed structures fractional anisotropy sizes. similarities measures across mimic shared variance reported based family structural phenotypes.

Language: Английский

Citations

54
Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci DOI Creative Commons
Nora I. Strom, Zachary F. Gerring, Marco Galimberti

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Obsessive-compulsive disorder (OCD) affects ~1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on genetic etiology underlying biological mechanisms disorder. We conducted GWAS meta-analysis combining 53,660 OCD cases 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent significant SNPs SNP-based heritability 6.7%. Separate for clinical, biobank, comorbid, self-report sub-groups found no evidence sample ascertainment impacting our results. Functional positional QTL gene-based approaches identified 249 candidate risk genes OCD, which 25 were as putatively causal, highlighting WDR6, DALRD3, CTNND1 in MHC region. Tissue single-cell enrichment analyses highlighted hippocampal cortical excitatory neurons, along with D1- D2-type dopamine receptor-containing medium spiny playing role risk. displayed correlations 65 out 112 examined phenotypes. Notably, it showed positive all included psychiatric phenotypes, particular anxiety, depression, anorexia nervosa, Tourette syndrome, negative subset autoimmune disorders, educational attainment, body mass index.. This study marks step toward unraveling its landscape advances understanding genetics, providing foundation future interventions to address this debilitating

Language: Английский

Citations

12
An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration DOI Creative Commons
Odile A. van den Heuvel,

Premika S.W. Boedhoe,

Sara Bertolín

et al.

Human Brain Mapping, Journal Year: 2020, Volume and Issue: 43(1), P. 23 - 36

Published: March 10, 2020

Abstract Neuroimaging has played an important part in advancing our understanding of the neurobiology obsessive–compulsive disorder (OCD). At same time, neuroimaging studies OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites been bolstered ENIGMA consortium; this provides specific technical expertise for conducting multi‐site analyses, as well access a community scientists. In article, we outline background to, development of, and initial findings ENIGMA's working group, which currently consists 47 34 institutes 15 countries 5 continents, with total sample 2,323 patients 2,325 healthy controls. Initial work focused cortical thickness subcortical volumes, structural connectivity, brain lateralization children, adolescents adults OCD, also study commonalities distinctions different neurodevelopment disorders. Additional is ongoing, employing machine learning techniques. Findings date contributed neurobiological models provided model global scientific collaboration, number clinical implications. Importantly, shed new light questions about whether functional alterations found reflect neurodevelopmental changes, effects disease process, or medication impacts. We conclude summary ongoing ENIGMA‐OCD, consideration future directions research within beyond ENIGMA.

Language: Английский

Citations

70
Chimpanzee brain morphometry utilizing standardized MRI preprocessing and macroanatomical annotations DOI Creative Commons
Sam Vickery, William D. Hopkins, Chet C. Sherwood

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 23, 2020

Chimpanzees are among the closest living relatives to humans and, as such, provide a crucial comparative model for investigating primate brain evolution. In recent years, human mapping has strongly benefited from enhanced computational models and image processing pipelines that could also improve data analyses in animals by using species-specific templates. this study, we use structural MRI National Chimpanzee Brain Resource (NCBR) develop chimpanzee reference template Juna.Chimp spatial registration macro-anatomical parcellation Davi130 standardized whole-brain analysis. Additionally, introduce ready-to-use pipeline built upon CAT12 toolbox SPM12, implementing standard preprocessing framework chimpanzees. Applying approach 194 subjects, find strong evidence human-like age-related gray matter atrophy multiple regions of brain, well as, general rightward asymmetry regions.

Language: Английский

Citations

41
The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping DOI Creative Commons
Paul M. Thompson, Neda Jahanshad, Lianne Schmaal

et al.

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(1), P. 15 - 22

Published: Oct. 6, 2021

Abstract This Special Issue of Human Brain Mapping is dedicated to a 10‐year anniversary the Enhancing NeuroImaging Genetics through Meta‐Analysis (ENIGMA) Consortium. It reports updates from broad range international neuroimaging projects that pool data around world answer fundamental questions in neuroscience. Since ENIGMA was formed December 2009, initiative grew into worldwide effort with over 2,000 participating scientists 45 countries, and 50 working groups leading large‐scale studies human brain disorders. Over last decade, many lessons were learned on how best diverse sources. Working created develop methods analyze anatomical diffusion magnetic resonance imaging (MRI), resting state task‐based functional MRI, electroencephalography (EEG), magnetoencephalography (MEG), spectroscopy (MRS). The quest understand genetic effects development disease also led analyses scans an unprecedented scale. Genetic roadmaps cortex by researchers who collaborated perform statistically well‐powered common rare variants measures rates aging. Here, we summarize 31 papers this , covering: (a) technical approaches harmonize analysis different types data, (b) reviews decade work several ENIGMA's clinical groups, (c) new empirical reporting mapping patients substance use disorders, schizophrenia, bipolar major depression, posttraumatic stress disorder, obsessive compulsive epilepsy, stroke.

Language: Английский

Citations

38