Emotion regulation of social pain: double dissociation of lateral prefrontal cortices supporting reappraisal and distraction DOI Creative Commons

Licheng Mo,

Sijin Li, Si Cheng

et al.

Social Cognitive and Affective Neuroscience, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Abstract The dorsolateral prefrontal cortex (DLPFC) and ventrolateral (VLPFC) are both crucial regions involved in voluntary emotion regulation. However, it remains unclear whether the two show functional specificity for reappraisal distraction. This study employed transcranial magnetic stimulation (TMS) to explore, a real social interactive scenario, different lateral play relatively specific roles downregulating pain via Participants initially took part game, followed by receiving either active (the DLPFC- or VLPFC-activated group, n = 100 per group) control vertex-activated 100) TMS session. They were then instructed use distraction strategies downregulate any negative emotions evoked evaluation given their peers who interacted with them previously. Results demonstrated that TMS-activated DLPFC has greater beneficial effect during distraction, whereas activated VLPFC reappraisal. result investigated direct experience of extended previous findings on empathy-related responses affective pictures while also controlling confounding factors such as empathic concern. Therefore, we now confident double dissociation proposal

Language: Английский

The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback DOI
Sijin Li, Hui Xie,

Zixin Zheng

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 43(9), P. 2898 - 2910

Published: March 9, 2022

Abstract The ventrolateral prefrontal cortices (VLPFC) are crucial regions involved in voluntary emotion regulation. However, the lateralization of VLPFC downregulating negative emotions remains unclear; and whether causal role is generalizable to upregulating positive unexplored. This study used transcranial magnetic stimulation (TMS) examine relationship between left/right social reappraisal. One hundred twenty participants were randomly assigned either active (left right groups, n = 40/40) or sham (vertex, 40) TMS groups. Participants instructed passively receive feedback use reappraisal strategies positively regulate their emotions. While subjective emotional rating showed that bilateral facilitated success, electrophysiological measure late potential (LPP) demonstrated a more critical on pain relief (decreased LPP amplitudes) reward magnification (enhanced amplitudes). In addition, influence regulation evaluation was found be mediated by memory feedback, indicating importance behavioral shaping. These findings suggest clinical protocols for rehabilitation emotion‐regulatory function patients with affective disorders.

Language: Английский

Citations

41
The VLPFC-Engaged Voluntary Emotion Regulation: Combined TMS-fMRI Evidence for the Neural Circuit of Cognitive Reappraisal DOI Creative Commons
Zhenhong He, Sijin Li,

Licheng Mo

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(34), P. 6046 - 6060

Published: July 28, 2023

A clear understanding of the neural circuit underlying emotion regulation (ER) is important for both basic and translational research. However, a lack evidence based on combined neuroimaging neuromodulation techniques calls into question (1) whether change prefrontal-subcortical activity intrinsically causally contributes to ER effect; (2) prefrontal control system directly modulates subcortical affective system. Accordingly, we fMRI recordings with transcranial magnetic stimulation (TMS) map causal connections between PFC structures (amygdala insula). total 117 human adult participants (57 males 60 females) were included in study. The results revealed that TMS-induced ventrolateral (VLPFC) facilitation led enhanced VLPFC ventromedial (VMPFC) as well attenuated amygdala insula during reappraisal but not nonreappraisal (i.e., baseline). Moreover, activated intensified couplings via VMPFC only. This study provides TMS-fMRI downregulating negative involves suppressing system, serving crucial hub within VLPFC-subcortical network, suggesting an indirect pathway model circuit. Our findings outline potential protocols improving ability by intensifying VLPFC-VMPFC coupling patients mood anxiety disorders.SIGNIFICANCE STATEMENT Using examine TMS effect, uncovered opposite changes (enhanced) (attenuated) regions are byproduct (ER); instead, this per se effect. Furthermore, using amplify circuit, "bridge" role highlighted under versus contrast. "perturb-and-measure" approach overcomes correlational nature data, helping us identify brain support (the VMPFC) those modulated systems valuable

Language: Английский

Citations

22
The role of ventrolateral prefrontal cortex on voluntary emotion regulation of social pain DOI Creative Commons

Wenwen Yu,

Yiwei Li, Xueying Cao

et al.

Human Brain Mapping, Journal Year: 2023, Volume and Issue: 44(13), P. 4710 - 4721

Published: June 27, 2023

Abstract The right ventrolateral prefrontal cortex (rVLPFC) is highly engaged in emotion regulation of social pain. However, there still lack both inhibition and excitement evidence to prove the causal relationship between this brain region voluntary regulation. This study used high‐frequency (10 Hz) low‐frequency (1 repetitive transcranial magnetic stimulation (rTMS) separately activate or inhibit rVLPFC two groups participants. We recorded participants' ratings as well their attitude prosocial behaviors following Also, we eye tracker record changes pupil diameter measure emotional feelings objectively. A total 108 healthy participants were randomly assigned activated, inhibitory sham rTMS groups. They required accomplish three sequential tasks: (cognitive reappraisal) task, favorability rating donation task. Results show that rVLPFC‐inhibitory group reported more negative emotions showed larger while rVLPFC‐activated less reduced during (both compared with group). In addition, activated gave positive evaluation peers donated money a public welfare activity than group, among which change was mediated by regulated emotion. Taken together, these findings reveal plays role pain can be potential target treating deficits psychiatric disorders.

Language: Английский

Citations

11
Extremely negative emotion interferes with cognition: Evidence from ERPs and time-varying brain network DOI

Kai Yang,

Ying Zeng, Li Tong

et al.

Journal of Neuroscience Methods, Journal Year: 2023, Volume and Issue: 396, P. 109922 - 109922

Published: July 16, 2023

Language: Английский

Citations

11
Transcranial magnetic stimulation and transcranial direct current stimulation affect explicit but not implicit emotion regulation: a meta-analysis DOI Creative Commons

Xiufu Qiu,

Zhenhong He, Xueying Cao

et al.

Behavioral and Brain Functions, Journal Year: 2023, Volume and Issue: 19(1)

Published: Sept. 19, 2023

Abstract Emotion regulation (ER) refers to the process through which people influence occurrence, experience, and expression of emotions. It can be established in an explicit (voluntary) or implicit (automatic) way, both are essential for mental physical well-being. Recent evidence has highlighted potential transcranial magnetic stimulation (TMS) direct current (tDCS) targeting prefrontal cortex (PFC) modulate ER. However, previous studies have only evaluated effects TMS tDCS on ER, leaving ER relatively unexplored. In this review meta-analysis, we systematically over PFC two forms using subjective physiological response as outcome indicators. Twenty-seven were included our study. Both ( Hedges’ g = − 0.20) 0.65) results indicated a significant effect down-regulation but not 0.04). Moreover, moderation analysis that down-regulating experience was moderated by several factors, including method, target area, hemisphere, timing. Specifically, showed applying right PFC, particularly ventrolateral cortex, offline produced larger summary, these findings suggest positive explicit, The distinct help deepen understanding use provide valuable insights development tailored protocols regulation.

Language: Английский

Citations

11
Positive resonance: Successful interpersonal emotion regulation facilitated relationship closeness by enhanced inter-brain synchronization DOI Creative Commons

Tongtong Zhu,

Xiaoxuan Zhang,

Luyao Jin

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121042 - 121042

Published: Jan. 1, 2025

Interpersonal emotion regulation (IER) refers to the dynamic process where a regulator employs specific strategies alleviate target's distress. It remains unclear whether successful IER could facilitate interpersonal relationship closeness (IRC). The present study aimed explore IER, based on two typical strategies-cognitive reappraisal (CR) and expressive suppression (ES)-for down-regulating negative emotions, enhance IRC among friend dyads, identify underlying neural correlates of this using functional near-infrared spectroscopy system. Seventy-four female dyads (friends) were randomly assigned one strategy groups (CR vs. ES), with participant as target other regulator. Our finds revealed that both have down-regulated however, CR was associated more outcomes (more improvement targets' emotions; higher IRC) than ES strategy. recruited enhanced brain synchronization (IBS) prefrontal temporal areas dyads. IBS above-mentioned networks in sadness, reversed pattern found anger, inferring successive effective anger. increased these regions played mediational role between effectiveness emotions increment IRC. findings coupling mechanism through which fostered supportive social bonds.

Language: Английский

Citations

0
Neuroenhancement by repetitive transcranial magnetic stimulation (rTMS) on DLPFC in healthy adults DOI
Elias Ebrahimzadeh, Seyyed Mostafa Sadjadi,

Mostafa Asgarinejad

et al.

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Reduction of rejection‐related emotions by transcranial direct current stimulation over right ventrolateral prefrontal cortex in borderline personality disorder: A double‐blind randomized pilot study DOI Creative Commons

Alessandro Lisco,

Alessia Gallucci,

Chiara Fabietti

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Borderline personality disorder (BPD) patients show negative emotional reactions to both excluding and including social scenarios, with levels normalizing only during extreme inclusion. Prior research among healthy individuals highlights the right ventrolateral prefrontal cortex (rVLPFC) role in regulating responses exclusion, since transcranial direct current stimulation (tDCS) of rVLPFC decreases rejection-related emotions following exclusion. This pilot study investigated whether, BPD patients, tDCS over reduces not after exclusion but also fair Forty randomly received either real or sham on before participating Cyberball paradigm, which involved phases inclusion, over-inclusion. Participants self-reported their level each phase. Transcranial reduced Specifically, those Real group exhibited comparable over-including unlike Sham who experienced heightened inclusion compared patients' tendency feel rejected fairly scenarios. These findings confirm involvement regulation highlight a therapeutic potential for moderating BPD's typical supports application treatment, providing new insights into neuromodulatory interventions that can aid better regulate varying

Language: Английский

Citations

0
The medial prefrontal cortex as a proposed regulatory structure in the relationship between anxiety and perceived social support: a review DOI Creative Commons

D. A Navarro-Nolasco,

Donají Chi-Castañeda, María Leonor López‐Meraz

et al.

BMC Psychology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 21, 2025

Perceived social support is recognized as a critical protective factor against the development of mental health disorders. Anxiety disorders are most common group and have substantial impact on individuals' well-being. Despite extensive research anxiety perceived support, significant gap exists in our understanding neural mechanisms linking these two phenomena. While several brain regions, including amygdala, hippocampus, insula, been implicated regulation processing, medial prefrontal cortex (mPFC) emerges particularly intriguing structure due to its central role emotional processing. Here, we hypothesize that mPFC serves potential substrate mediating relationship between support. To hypothesis, conducted literature search PubMed database using systematic Boolean strategy. In total, 43 articles met inclusion criteria. The reviewed studies suggest may play an essential regulating effect levels. evidence indicates individuals with higher levels exhibit enhanced regulatory control over anxiety-related processes, this effect. Understanding underpin crucial for devising targeted interventions. Further investigation into mPFC's candidate domain could provide invaluable insights aid new therapeutic strategies management anxiety.

Language: Английский

Citations

0
Abnormal resting-state brain networks and their relationship with cognitive reappraisal preferences in college students with depressive tendencies DOI
Yan Sun,

Xinge Mao,

Peiyu Hou

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149522 - 149522

Published: Feb. 1, 2025

Language: Английский

Citations

0