Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity DOI Creative Commons
Kun Fu,

Shuyue Xu,

Zheng Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet clinical translation into novel interventions for pathological fear requires behavioral neurofunctional characterization under close-to-real life conditions. Here, we combined naturalistic fMRI-design inducing high immersive experience in social non-social contexts with preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n = 67 healthy men). reduced subjective small or moderate effect sizes, respectively. In contexts, enhanced left middle cingulate cortex (lMCC) activation its functional connectivity contralateral amygdala, both neural indices significantly inversely associated following OT. On network level, communication between dorsal attention (DAN) fronto-parietal (FPN) default-mode (DMN) as well on more fine-grained level brain-wide communication. These findings indicate fear-reducing conditions pronounced effects suggesting treatment value disorders context-related excessive fear.

Language: Английский

Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex DOI Creative Commons
Vivien Csikós, Fanni Dóra,

Tamás Láng

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1043 - 1043

Published: June 17, 2024

(1) Background: The effects of short-term social isolation during adulthood have not yet been fully established in rats behaviourally, and at all transcriptomically the medial prefrontal cortex (mPFC). (2) Methods: We measured behavioural housing adult male pairs or alone for 10 days. also used RNA sequencing to measure accompanying gene expression alterations mPFC rats. (3) Results: isolated animals exhibited reduced sociability novelty preference, but increased interaction. There was no change their aggression, anxiety, depression-like activity. Transcriptomic analysis revealed a differential 46 genes between groups. KEGG pathway showed that differentially expressed are involved neuroactive ligand-receptor interactions, particularly dopaminergic peptidergic systems, addiction. Subsequent validation confirmed decreased level three altered genes: regulator G protein signalling 9 (Rgs9), serotonin receptor 2c (Htr2c), Prodynorphin (Pdyn), which dopaminergic, serotonergic, function, respectively. Antagonizing Htr2c its role discrimination. (4) Conclusions: Social homeostatic regulations include monoaminergic systems mPFC.

Language: Английский

Citations

3
Oxytocin enhances the triangular association among behavior, resting‐state, and task‐state functional connectivity DOI Creative Commons
Haoming Zhang, Kun Chen, Jin Bao

et al.

Human Brain Mapping, Journal Year: 2023, Volume and Issue: 44(17), P. 6074 - 6089

Published: Sept. 29, 2023

Considerable advances in the role of oxytocin (OT) effect on behavior and brain network have been made, but OT association between inter-individual differences functional connectivity (FC) is elusive. Here, by using a face-perception task multiple connectome-based predictive models, we aimed to (1) determine whether could enhance among behavioral performance, resting-state FC (rsFC), task-state (tsFC) (2) if so, explore enhancing this triangular association. We found that group, prediction performance rsFC or tsFC predict was higher than PL group. Additionally, correlation coefficient substantially group The strength these associations be partly explained altering brain's FCs related social cognition face perception both resting states, mainly regions such as limbic system, prefrontal cortex, temporal poles, temporoparietal junction. Taken together, results provide novel evidence corresponding mechanism for how neuropeptides cause increased across different levels (e.g., large-scale networks task-state), may inspire future research cross clinical nonclinical use.

Language: Английский

Citations

4
Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity DOI Creative Commons
Benjamin Becker, Kun Fu,

Shuyue Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet clinical translation into novel interventions for pathological fear requires behavioral neurofunctional characterization under close-to-real life conditions. Here, we combined naturalistic fMRI-design inducing high immersive experience in social non-social contexts with preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n\(=\)67 healthy men). reduced subjective small or moderate effect sizes, respectively. In contexts, enhanced left middle cingulate cortex (lMCC) activation its functional connectivity contralateral amygdala, both neural indices significantly inversely associated following OT. On network level, communication between dorsal attention (DAN) fronto-parietal (FPN) default-mode (DMN) as well on more fine-grained level brain-wide communication. These findings indicate fear-reducing conditions pronounced effects highlighting value treatment option disorders characterized by excessive situations.

Language: Английский

Citations

0
Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity DOI Creative Commons
Kun Fu,

Shuyue Xu,

Zheng Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet clinical translation into novel interventions for pathological fear requires behavioral neurofunctional characterization under close-to-real life conditions. Here, we combined naturalistic fMRI-design inducing high immersive experience in social non-social contexts with preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n = 67 healthy men). reduced subjective small or moderate effect sizes, respectively. In contexts, enhanced left middle cingulate cortex (lMCC) activation its functional connectivity contralateral amygdala, both neural indices significantly inversely associated following OT. On network level, communication between dorsal attention (DAN) fronto-parietal (FPN) default-mode (DMN) as well on more fine-grained level brain-wide communication. These findings indicate fear-reducing conditions pronounced effects suggesting treatment value disorders context-related excessive fear.

Language: Английский

Citations

0