Dysfunction in the hierarchy of morphometric similarity network in Alzheimer’s disease and its correlation with cognitive performance and gene expression profiles

Psychological Medicine, Journal Year: 2025, Volume and Issue: 55

Published: Jan. 1, 2025

Abstract Background Previous research has shown abnormal functional network gradients in Alzheimer’s disease (AD). Structural gradient is capable of capturing continuous changes brain morphology and the ability to elucidate underlying processes neurodevelopment. However, it remains unclear whether structural are altered AD what associations exist between these cognitive function, gene expression profiles. Methods By constructing an individualized decomposition framework, we calculated morphological similarity (MSN) for 404 subjects (186 patients 218 normal controls). We investigated AD-related alterations MSN gradients, along with topological properties, Results Our findings indicated that principal were primarily characterized by increase primary secondary sensory cortices a decrease association cortex 1. The higher-order exhibited opposite cognition, including executive language skills, memory processes. Moreover, found significantly predict function AD. pattern was 14.8% attributable profiles, genes demonstrating highest correlation involved metabolic activity synaptic signaling. Conclusions results offered novel insights into mechanisms impairment patients, enhancing our understanding neurobiological responsible impaired cognition AD, offering new dimensional biomarker

Language: Английский

Disruption of structural connectome hierarchy in age-related hearing loss

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 17, 2025

Age-related hearing loss (ARHL) is a common sensory disability among older adults and considered risk factor for the development of dementia. Previous work has shown altered brain connectome topology in ARHL, including abnormal nodal strength clustering coefficient. However, whether ARHL affects hierarchical organization structural how these alterations relate to transcriptomic signatures remain unknown. Here, we apply gradient mapping framework derived from diffusion magnetic resonance imaging. We focus on first three gradients that reflect distinct connectome, assess ARHL-related changes. find that, compared controls, patients exhibit widespread disruptions organization, spanning primary areas (e.g., somatomotor network) high-order association default mode network). Subsequently, by employing subcortical-weighted weighting cortical subcortical-cortical connectivity, observe show significantly connectivity left caudate, nucleus accumbens, right hippocampus, amygdala. Finally, investigate relationship between gene expression gradients. are associated with weighted profiles, relevant genes preferentially enriched inorganic ion transmembrane transport terms related regulating biological processes. Taken together, findings highlight hierarchy reveal relevance abnormalities, contributing richer understanding neurobiological substrates ARHL.

Language: Английский