EXPLORING THE LINK BETWEEN EARLY DETECTION AND SURVIVAL OUTCOMES IN SPINAL MUSCULAR ATROPHY PATIENTS DOI Creative Commons

Paras Ali,

I. Petkov,

Muhammad Zulkifal

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 382 - 389

Published: Feb. 9, 2024

Introduction: Spinal Muscular Atrophy (SMA) is a recessive neurodegenerative disorder characterized by the homozygous deletion or mutation of SMN1 gene, responsible for producing motor neuron survival protein (SMN). This genetic anomaly results in deficiency SMN production, leading to alpha (α) degeneration, causing progressive muscle weakness and paralysis. Objective: study aims explore pathophysiology spinal muscular atrophy, discuss potential treatments, highlight recent advancements our understanding disease. Method: Data this review was collected from articles available on SciELO, PubMed, MEDLINE, providing comprehensive overview current state knowledge atrophy. Results: Treatment strategies SMA encompass multidisciplinary approach, including nutritional interventions, physical therapy, respiratory care, cutting-edge gene therapy. Recent studies have contributed valuable insights into these treatment modalities, offering hope improved outcomes. Conclusion: Patients with atrophy often contend spectrum conditions, necessitating individualized care. underscores importance ongoing research, multidimensional approaches, patient-centric care enhance quality life individuals affected SMA.

Language: Английский

Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study DOI Creative Commons
Mirna Bazina, Rayan Nikkilä, Aaro Haapaniemi

et al.

Acta Oncologica, Journal Year: 2025, Volume and Issue: 64, P. 339 - 348

Published: March 4, 2025

Background and purpose: Knowledge regarding the risk factors for early death in patients with head neck squamous cell carcinoma (HNSCC) is scarce. This study aims to evaluate rate of (during or within 6 months treatment) its associated HNSCC treated curative intent. Materials methods: A retrospective, population-based analysis all (n = 762) intent at Helsinki University Hospital (Helsinki, Finland) during 2012–2015 was conducted. Using chi-square test, associations between categorical variables were assessed. Univariate multivariate analyses performed identify independent death. Results: The 10.1% a median age 70 years diagnosis. Advanced stage, smoking > 40 pack-years, heavy alcohol consumption increased odds Elevated thrombocyte levels 380 (× 10⁹L) observed more frequently early-death group when comparing late-death (p < 0.01). However, only (odds ratio [OR] 1.05; 95% confidence interval [CI]:1.02–1.08), T4 class (OR 5.98; CI: 2.60–13.74), N2 2.98; N3 12.24; 2.99–50.19) emerged as Interpretation: Early older those advanced-stage HNSCC. count requires further studies assess utility potential clinical marker.

Language: Английский

Citations

0
Association of loss of visceral adipose tissue after concurrent chemoradiotherapy with poor survival in patients with head and neck squamous cell carcinoma DOI
Sang Mi Lee, In Young Jo, Jae Hong Park

et al.

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112775 - 112775

Published: March 1, 2025

Language: Английский

Citations

0
EXPLORING THE LINK BETWEEN EARLY DETECTION AND SURVIVAL OUTCOMES IN SPINAL MUSCULAR ATROPHY PATIENTS DOI Creative Commons

Paras Ali,

I. Petkov,

Muhammad Zulkifal

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 382 - 389

Published: Feb. 9, 2024

Introduction: Spinal Muscular Atrophy (SMA) is a recessive neurodegenerative disorder characterized by the homozygous deletion or mutation of SMN1 gene, responsible for producing motor neuron survival protein (SMN). This genetic anomaly results in deficiency SMN production, leading to alpha (α) degeneration, causing progressive muscle weakness and paralysis. Objective: study aims explore pathophysiology spinal muscular atrophy, discuss potential treatments, highlight recent advancements our understanding disease. Method: Data this review was collected from articles available on SciELO, PubMed, MEDLINE, providing comprehensive overview current state knowledge atrophy. Results: Treatment strategies SMA encompass multidisciplinary approach, including nutritional interventions, physical therapy, respiratory care, cutting-edge gene therapy. Recent studies have contributed valuable insights into these treatment modalities, offering hope improved outcomes. Conclusion: Patients with atrophy often contend spectrum conditions, necessitating individualized care. underscores importance ongoing research, multidimensional approaches, patient-centric care enhance quality life individuals affected SMA.

Language: Английский

Citations

0