The Burden of Recurrent Head and Neck Squamous Cell Carcinoma Across the United Kingdom: Results From a National Snapshot Study DOI Open Access
Andrew Williamson, Alison E Lim,

FR Green

et al.

Head & Neck, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Background To investigate the management of recurrent head and neck squamous cell carcinoma (rHNSCC) describe survival outcomes. Methods Post hoc subgroup analysis a retrospective national observational cohort was conducted. All patients with rHNSCC who received definitive treatment decision between September 1, 2021 November 30, were included. Survival stratified according to subsite, primary versus disease, surgical nonsurgical treatment. Results Data from 202 derived 1488 submitted by 50 UK centers. Median age 66 years (IQR 58–74), 142 (70.3%) male. The most common recurrence subsites oropharynx (20.5%), oral cavity (19.5%), larynx (16.4%), hypopharynx (14.9%). Ninety‐three (48.4%) managed curatively. Surgery for laryngeal (59.4%), (60.5%), hypopharyngeal (44.8%), oropharyngeal (37.5%) cancers. Two‐year overall (OS), disease‐free (DFS), disease‐specific (DSS), local free (LRFS) 41.1%, 39.1%, 42.2%, 39.3%, respectively. treated surgery had improved OS ( p = 0.0005), DFS 0.012), DSS 0.0003), LRFS 0.007), over treatments. Compared cancers, presents more advanced T stage < 0.001) distant metastasis 0.001), receives less curative has worse outcomes (all 0.001). On multivariate analysis, salvage surgery, radiotherapy, p16 status independent prognostic factors all Conclusions Recurrent HNSCC is associated high rates incurable disease than remains in rHNSCC, however future studies are necessary improve patient selection optimize following

Language: Английский

Análisis de la supervivencia de los pacientes con tumores malignos de cabeza y cuello diagnosticados durante la pandemia de COVID-19 DOI
Xavier León, Cristina Valero, Anna Holgado

et al.

Acta Otorrinolaringológica Española, Journal Year: 2025, Volume and Issue: 76(2), P. 106 - 115

Published: Feb. 16, 2025

Citations

0
The Burden of Recurrent Head and Neck Squamous Cell Carcinoma Across the United Kingdom: Results From a National Snapshot Study DOI Open Access
Andrew Williamson, Alison E Lim,

FR Green

et al.

Head & Neck, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Background To investigate the management of recurrent head and neck squamous cell carcinoma (rHNSCC) describe survival outcomes. Methods Post hoc subgroup analysis a retrospective national observational cohort was conducted. All patients with rHNSCC who received definitive treatment decision between September 1, 2021 November 30, were included. Survival stratified according to subsite, primary versus disease, surgical nonsurgical treatment. Results Data from 202 derived 1488 submitted by 50 UK centers. Median age 66 years (IQR 58–74), 142 (70.3%) male. The most common recurrence subsites oropharynx (20.5%), oral cavity (19.5%), larynx (16.4%), hypopharynx (14.9%). Ninety‐three (48.4%) managed curatively. Surgery for laryngeal (59.4%), (60.5%), hypopharyngeal (44.8%), oropharyngeal (37.5%) cancers. Two‐year overall (OS), disease‐free (DFS), disease‐specific (DSS), local free (LRFS) 41.1%, 39.1%, 42.2%, 39.3%, respectively. treated surgery had improved OS ( p = 0.0005), DFS 0.012), DSS 0.0003), LRFS 0.007), over treatments. Compared cancers, presents more advanced T stage < 0.001) distant metastasis 0.001), receives less curative has worse outcomes (all 0.001). On multivariate analysis, salvage surgery, radiotherapy, p16 status independent prognostic factors all Conclusions Recurrent HNSCC is associated high rates incurable disease than remains in rHNSCC, however future studies are necessary improve patient selection optimize following

Language: Английский

Citations

1