Oral Oncology, Journal Year: 2025, Volume and Issue: 165, P. 107306 - 107306
Published: April 25, 2025
Language: Английский
The Laryngoscope, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Objective To identify the most effective treatment modality for achieving favorable outcomes in early glottic tumors with anterior commissure involvement (ACI). Data Sources PubMed, Embase, Web of Science, and ScienceDirect. Review Methods Random‐effects proportional meta‐analysis model is used to evaluate oncological functional transoral laser microsurgery (TLM) versus radiation therapy (RT) (T1–T2) cancer ACI. Results From a total 736 studies, 40 studies were included, comprising 2666 tumor patients TLM (52%) upfront RT (48%) primary groups. had better 5‐year overall survival (OS) (84.5% [80.3%–88.0%] vs. 79.4% [75.7%–82.7%]). Similarly, TLM‐treated 3‐year pooled disease‐free (DFS) compared RT‐treated (82.7% [77.1%–87.1%] 73.3% [23.8%–96.0%]). exhibited local control rate (LCR) than (77.2% 71.6%). In our temporal analysis, higher LCR (78.2% 63.5%) 2001–2012, similar rates 2013–2024 (76.8% 78.4%). laryngeal preservation (93% [90.6%–94.8%] 87.6% [82.8%–91.2%]). Conclusions Our first literature compare between ACI tumors. appear have superior OS patients. However, both comparable during recent period from 2013 2024. Laryngoscope , 2025
Language: Английский
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Head & Neck, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
ABSTRACT Background In sinonasal cancer (SNC), treatment with proton therapy (PT) provides excellent local control, especially after gross total resection. Because of the heterogeneity and rarity this disease site, a comprehensive assessment toxicity, survival, control rates is lacking. Our primary objective was to assess toxicity outcomes PT in SNC patients, secondary aim assessing survival tumor PT. Methods PubMed, Embase, EBSCO, Scopus, Science Direct, Web Science, Ovid, Proquest, Cochrane Library were searched from inception August 2024 reporting acute late patients. A random‐effect meta‐analysis used pooled safety, outcomes. The analysis report toxicity. aims included overall (OS), disease‐free (DFS), (LC), regional (RC), distant metastasis (DMC) rate. Results Fourteen studies for qualitative analysis. We data 756 patients who received SNC. Among (AT), there 31.9% occurrence rate grade ≥ 3 events, whereas within (LT), events occurred at 35.3%. Most LT (62.1%) classified as 2, most frequent being ocular (24.8%) or neurological (18.4%) toxicities. common toxicities mucositis (15.3%) AT (9.6%) LT. 5‐year OS, DFS, LC, RC, DMC 36.8%, 34.2%, 35.6%, 28.6%, 54.3%, respectively. Conclusion demonstrates that PT‐treated experience acceptable consistent other published highly conformal radiation techniques. favorable OS DFS. Further prospective comparative effectiveness research needed better quantify magnitude benefit forms modalities.
Language: Английский
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Head & Neck, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
ABSTRACT Background Head and neck cancer (HNC) due to its nature proximity essential vasculature, along with different treatments, can lead stroke, significantly contributing morbidity mortality. Our aim is systematically evaluate the association of stroke incidence, mortality, predictors HNC treatment. Methods Pubmed, Web Science, Embase, ScienceDirect were searched from inception July 2024 for articles reporting incidences, or associated risk factors following treatment in patients. A random‐effects meta‐analysis assessed cumulative incidence mortality rates proportional analysis using hazard ratios (HRs) Subgroup analyses conducted pre‐ post‐2010 periods, reflecting changes protocols. Results Out 1561 studies, 69 studies 258 850 patients included. The global was 4.1% (95% CI: 3.3%–5.0%), similar before after 2010 (4.4% vs. 4.0%). In undergoing chemoradiotherapy (CRT), 4.9% 3.5%–6.7%) a median time first 45 months (range: 14–51.7 months). Following radiation therapy (RT), 3.8% 2.7%–5.3%) 36 6.8–130 higher compared general population (HR: 1.69, 95% 1.24–2.31, p = 0.001). Stroke decreased 28.5% 11.6%–54.9%) pre‐2010 14.5% 11.6%–17.9%) 2010–2024. 39.3% 17.8%–66.0%) post‐CRT 21% 7.2%–47.7%) post‐RT. Hypertension (HR 1.75), diabetes 1.71), age > 65 2.17) increased ( < 0.0001 all). Geographically, South Korea (6.6%) had highest stroke. Conclusion This systematic review analyze between (pre‐2010 2010–2024), CRT group (39.3%). Given that occurs 36–45 CRT, screening protocol within 3–4 years crucial.
Language: Английский
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Acta Oto-Laryngologica, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7
Published: Feb. 21, 2025
Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis. This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS. We conducted systematic review cases using PubMed, OVID, Scopus, Web Science, ScienceDirect, EBSCO from inception October 2024. Given data on individual patient follow-up, Kaplan-Meier analysis was utilized calculate disease-free (DFS) disease-specific (DSS). Out 303 articles, 10 studies 11 patients (72.7% male) met inclusion criteria, mean age 51.3 years (range: 12-77.5). Preoperative fine needle aspiration cytology in 45.4%, 80% yielding inconclusive results. The 2-year 5-year DFS rates for PPS-LS were 64% 50%, respectively, while DSS rate 84%. Tumor recurrence occurred 36.3% patients, an average 2.5 recurrences per patient, specifically myxoid subtype highlights varied prognostic its subtypes, emphasizing need vigilant surveillance improve reduce rates. provides surgeons critical insights into probable when dealing specific
Language: Английский
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Oral Oncology, Journal Year: 2025, Volume and Issue: 165, P. 107306 - 107306
Published: April 25, 2025
Language: Английский
Citations
0