TSAT-Urated Insights: Clarifying the Complexities of Hereditary Hemochromatosis and Its Guidelines DOI Creative Commons

Chiara Marcon,

Marta Medeot,

A. Michelazzi

et al.

Hemato, Journal Year: 2024, Volume and Issue: 5(4), P. 459 - 489

Published: Dec. 11, 2024

Hereditary hemochromatosis (HH) related to HFE-gene mutations is a well-known condition, yet its understanding remains complex. The BIOIRON classification emphasizes that only homozygosity for the C282Y mutation should be considered pathogenic. penetrance of HFE-related HH highly variable. Symptoms are often challenging recognize at time presentation, and systemic involvement may overlap with other diseases. Hyperferritinemia elevated transferrin saturation levels still milestones in diagnosis, but they also common findings many clinical conditions. Furthermore, current diagnostic therapeutic guidelines not always unequivocal defining patients’ characteristics, as well treatment management goals. Our work provides concise overview latest evidence regarding pathogenic mechanisms, picture, differential diagnosis tools. Alongside this, it summarizes compares main recommendations from principal issued by 2017 Hemochromatosis International Meeting, American College Gastroenterology, European Association Study Liver, Molecular Genetics Quality Network, DUTCH guidelines, British Society Haematology. Summarizing tables quick consultation provided.

Language: Английский

Insights into Maternal Health: Mentzer Index for Early Anemia Detection DOI Creative Commons
Emmanuel Ifeanyi Obeagu,

Getrude Uzoma Obeagu

International Journal of Medical Sciences and Pharma Research, Journal Year: 2024, Volume and Issue: 10(4), P. 44 - 49

Published: Dec. 15, 2024

The Mentzer Index is a widely used hematological tool for differentiating between iron deficiency anemia and thalassemia, especially in resource-limited settings where advanced diagnostic options may be unavailable. Calculated as the ratio of mean corpuscular volume (MCV) to red blood cell (RBC) count, it provides quick accessible method screening. For values over 13, more likely, while below 13 typically indicate thalassemia. This simplicity makes advantageous primary healthcare community health settings, supporting early detection intervention at-risk populations, including pregnant women children. Despite its usefulness, has limitations, reduced specificity accuracy cases coexisting types, variations age, ethnic differences. Factors such chronic inflammation, pregnancy-induced hemodilution, concurrent conditions can alter MCV RBC values, potentially skewing index leading misclassification. Additionally, standard cut-off value not universally apply all highlighting need localized studies validate diverse demographic clinical groups. Moreover, reliant on accurate laboratory results, which challenging low-resource with limited access quality-controlled equipment. Keywords: Index, detection, maternal health, anemia, diagnosis, pregnancy complications

Language: Английский

Citations

11

Anemia in Pregnancy: Mentzer Index as a Predictor for Iron Supplementation Needs DOI Creative Commons
Emmanuel Ifeanyi Obeagu,

Getrude Uzoma Obeagu

International Journal of Medical Sciences and Pharma Research, Journal Year: 2024, Volume and Issue: 10(4), P. 39 - 43

Published: Dec. 15, 2024

Anemia during pregnancy is a significant public health concern that affects substantial proportion of women globally, with iron deficiency anemia being the most prevalent form. Effective early diagnosis and intervention are crucial to prevent adverse outcomes for both mothers infants. The Mentzer Index, simple calculation derived from mean corpuscular volume (MCV) red blood cell (RBC) count, serves as useful tool differentiate between thalassemia, thereby guiding appropriate treatment strategies. By categorizing type anemia, healthcare providers can more accurately assess need supplementation, which essential managing but may not be beneficial in cases thalassemia. Index has gained recognition its ease use, especially resource-limited settings where access advanced laboratory diagnostics restricted. With straightforward calculation, it allows rapid screening pregnant presenting symptoms. This index only aids timely also supports targeted interventions, ensuring supplementation administered those who truly it. approach minimizes risk complications associated unnecessary individuals thalassemia or other forms highlighting importance accurate diagnostic tools maternal care. Keywords: Anemia, Pregnancy, Iron Supplementation, Deficiency, Thalassemia, Hematological Indices, Maternal Health

Language: Английский

Citations

10

Screening for Thalassemia Traits in Pregnancy: The Role of Mentzer Index DOI Creative Commons
Emmanuel Ifeanyi Obeagu,

Getrude Uzoma Obeagu

International Journal of Medical Sciences and Pharma Research, Journal Year: 2024, Volume and Issue: 10(4), P. 50 - 55

Published: Dec. 15, 2024

Thalassemia traits present significant challenges during pregnancy, often leading to complications such as anemia and adverse maternal fetal outcomes. Early identification of carriers is essential for managing these risks providing appropriate care. This review article examines the Mentzer Index, a straightforward cost-effective tool derived from complete blood count (CBC) parameters, which can effectively screen thalassemia in pregnant women. By calculating ratio mean corpuscular volume (MCV) red cell (RBC) count, Index serves valuable first-line screening measure, facilitating timely referrals further diagnostic testing. The relevance early detection underscored by need informed reproductive choices tailored management strategies. Recognizing allows healthcare providers monitor affected women closely implement interventions, ultimately improving health Furthermore, easily applicable various clinical settings, particularly resource-limited environments where access advanced laboratory testing may be limited. Keywords: Thalassemia, anemia, screening, health, carrier detection.

Language: Английский

Citations

8

Iron-Deficiency Anemia in Chronic Kidney Disease: A Literature Review of Its Pathophysiology, Diagnosis, and Management DOI Open Access
Shahwar Kazmi,

Viktoriia Zarovniaeva,

Kimberly Perez

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Anemia is a prevalent complication of chronic kidney disease (CKD) and associated with increased mortality reduced health-related quality life. The iron-rich protein hemoglobin, which the body utilizes to carry oxygen, deteriorates in anemia. Because hemoglobin that contains iron, disturbances iron homeostasis can lead iron-deficiency anemia (IDA). CKD frequently results anemia, linked poor prognosis. Nevertheless, whether per se or other comorbidities are reason for this connection remains unclear. Uncertainty surrounds distinct forms IDA forecast outcomes. Physicians, nurse practitioners, physician assistants, registered nurses work as team manage patients CKD. Individuals benefit from involvement different specialties along treatment continuum, dietitians/nutritionists play significant role enhancing management through multidisciplinary care. This literature review aims deliver comprehensive overview CKD, concentrating on its diagnosis. It addresses pathophysiology, complications deficiency, available diagnostic tests Furthermore, we analyze has contributed developing current practice guidelines treating encouraging collaboration managing

Language: Английский

Citations

0

Evaluation Of Diagnosis And Treatment Approaches Related To Iron Deficiency Of Family Physicians DOI Creative Commons
Kamil Konur, Elif Akdoğan

Turkish Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: 7(1), P. 22 - 27

Published: Jan. 28, 2025

Background Anaemia is defined by the World Health Organization (WHO) as a hemoglobin value below 13 g/dL in men and 12 women. It serious public health problem that can significantly affect quality of life. Methods Our study, whose universe consists family physicians who actively work centers Rize province, was conducted 2021. After being informed about our 81 agreed to participate voluntarily were included. Results research cross-sectional descriptive type research. A 20-question survey prepared scanning literature presented data collection tool. While 73 (90.1%) participants are general practitioners, 8 (8.9%) medicine specialists. The rate correctly knowing ferritin diagnose iron deficiency anemia patient without acute infection 70.4% (n: 57). diagnosis anemia, recommended gastrointestinal system screening 39.5% 32) all 87.7% 71) postmenopausal recommending treatment for 3-6 months after level returned normal 93.8% 76). Conclusion Based on we obtained, it seen physicians’ knowledge management insufficient, there deficiencies processes. For this reason, interactive, applied training programs should be organized.

Language: Английский

Citations

0

Clinical Presentation and Nutrition Management of Non‐IgE‐Mediated Food Allergy in Children DOI Open Access
Marion Groetch, Carina Venter,

Rosan Meyer

et al.

Clinical & Experimental Allergy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Non-IgE-mediated food allergy encompasses a wide spectrum of allergic disorders ranging from mild to severe presentations, including protein-induced proctocolitis, enterocolitis syndrome, and enteropathy. Other gastrointestinal symptoms such as constipation gastroesophageal reflux disease have not previously been recognised non-IgE-mediated in guideline publications. Recently, two new consensus documents the European Academy Allergy, Asthma Immunology address potential role allergens these disorders, where standard treatment has failed, provide guidance for diagnosis management conditions. Additional updates include World Allergy Organisation on cow's milk allergy, most commonly implicated allergy. These all help practitioners distinguish between common manifestations infancy that are pathologic Understanding diagnostic criteria is vital prevent overdiagnosis, limit unnecessary elimination diets preserve breastfeeding. Conversely, proper may reduce infants who affected. Therefore, first step establishing correct diagnosis, which requires understanding clinical presentations if needed, applying an appropriate short-term diet observe symptom resolution, followed by reintroduction assess recurrence. Once diagnosed, removal trigger food, milk, without burden nutrition risk. allergies typically resolve early childhood with some resolving therefore reassessment tolerance vital. Management entails following algorithms, developing individualised dietary plan, timely assessment development

Language: Английский

Citations

0

Mentzer Index as an Indicator of Hematological Health in Pregnant Populations: A Review DOI Creative Commons
Emmanuel Ifeanyi Obeagu

Asian Journal of Dental and Health Sciences, Journal Year: 2025, Volume and Issue: 5(1), P. 30 - 33

Published: March 15, 2025

Hematological health in pregnancy is crucial for ensuring favorable maternal and fetal outcomes, as often predisposes women to conditions like anemia. The Mentzer Index, a diagnostic ratio derived from routine complete blood count (CBC) parameters, has proven valuable distinguishing between iron-deficiency anemia (IDA) thalassemia traits, two prevalent yet distinct causes of pregnant populations. This tool's simplicity cost-effectiveness make it especially useful resource-limited settings, offering practical approach early diagnosis tailored management strategies. review highlights the role Index assessing hematological health, with focus on its application differentiating subtypes. By comparing mean corpuscular volume (MCV) red cell (RBC), index provides an accessible preliminary screening mechanism. While >13 indicates IDA, values <13 suggest enabling clinicians prioritize further evaluations, such serum ferritin levels or hemoglobin electrophoresis. timely differentiation essential avoiding inappropriate treatments, unwarranted iron supplementation carriers, which may lead complications overload. Keywords: Health, Pregnancy, Iron-Deficiency Anemia, Thalassemia Trait

Language: Английский

Citations

0

Clinical Utility of Mentzer Index in Pregnancy Anemia Screening Programs: A Narrative Review DOI Creative Commons
Emmanuel Ifeanyi Obeagu

Asian Journal of Dental and Health Sciences, Journal Year: 2025, Volume and Issue: 5(1), P. 40 - 44

Published: March 15, 2025

Anemia in pregnancy is a prevalent condition that can lead to severe complications for both mothers and their fetuses. Differentiating between the causes of anemia, particularly iron deficiency anemia (IDA) thalassemia traits, crucial appropriate treatment. The Mentzer Index (MI) simple, cost-effective tool used distinguish these two common microcytic by comparing mean corpuscular volume (MCV) red blood cell (RBC) count. This review explores clinical utility MI screening programs, highlighting its advantages, limitations, potential role improving diagnosis management. has proven be an effective first-line diagnostic tool, especially resource-limited settings where advanced testing may not readily available. By providing straightforward method differentiate IDA from helps prevent inappropriate use supplements, which exacerbate individuals with thalassemia. Additionally, simplicity allows incorporation into routine prenatal care, efficiency programs facilitating early intervention. Despite benefits, including reduced accuracy due physiological changes mixed anemia. Keywords: Index, screening, utility,

Language: Английский

Citations

0

Assessing Anemia in Pregnant Women: The Usefulness of the Mentzer Index DOI Creative Commons
Emmanuel Ifeanyi Obeagu

Asian Journal of Dental and Health Sciences, Journal Year: 2025, Volume and Issue: 5(1), P. 20 - 24

Published: March 15, 2025

Anemia during pregnancy is a prevalent concern, with iron deficiency anemia (IDA) and thalassemia trait (TT) being two common causes. Differentiating between these conditions crucial for effective management, as IDA requires supplementation, while TT does not. The Mentzer Index (MI) simple, cost-effective tool used to distinguish by analyzing the mean corpuscular volume (MCV) red blood cell (RBC) count. This review explores usefulness of in assessing pregnant women, its clinical applications, benefits, limitations practice. provides quick efficient means diagnosing types calculating ratio MCV RBC. A value below 13 typically suggests trait, higher points anemia. In pregnancy, where due increased demands, serves an essential guide treatment decisions. By helping clinicians avoid unnecessary supplementation women thalassemia, it reduces risk complications such overload, thereby improving patient outcomes. Keywords: Anemia, Pregnant Women, Index, Iron Deficiency, Thalassemia

Language: Английский

Citations

0

Empowering Girls and Women: Reducing HIV Risk through Education DOI Creative Commons
Emmanuel Ifeanyi Obeagu

Asian Journal of Dental and Health Sciences, Journal Year: 2025, Volume and Issue: 5(1), P. 45 - 49

Published: March 15, 2025

Education is very important to women and girls who are at the greatest risk of contracting HIV virus. However, more emphasis needed look information on how education improves transmission among also reduces inequalities gender roles which able increase infection rates. There a growing evidence that significant proportion postpone first intercourse, protect themselves against AIDS through safer sex practices advocate condom use in combination with regular testing an effective sexuality curriculum. Additionally, as have greater control over their sexual reproductive health less likely engage activities expose them HIV, promotes equality, crucial lowering risk. provides complete response epidemic by tackling underlying factors contribute susceptibility, including poverty, gender-based violence, early marriage. Girls receive capable fending forceful exploitative circumstances may HIV. Keywords: prevention, women’s education, adolescent health, empowerment

Language: Английский

Citations

0