Hemato,
Journal Year:
2024,
Volume and Issue:
5(4), P. 459 - 489
Published: Dec. 11, 2024
Hereditary
hemochromatosis
(HH)
related
to
HFE-gene
mutations
is
a
well-known
condition,
yet
its
understanding
remains
complex.
The
BIOIRON
classification
emphasizes
that
only
homozygosity
for
the
C282Y
mutation
should
be
considered
pathogenic.
penetrance
of
HFE-related
HH
highly
variable.
Symptoms
are
often
challenging
recognize
at
time
presentation,
and
systemic
involvement
may
overlap
with
other
diseases.
Hyperferritinemia
elevated
transferrin
saturation
levels
still
milestones
in
diagnosis,
but
they
also
common
findings
many
clinical
conditions.
Furthermore,
current
diagnostic
therapeutic
guidelines
not
always
unequivocal
defining
patients’
characteristics,
as
well
treatment
management
goals.
Our
work
provides
concise
overview
latest
evidence
regarding
pathogenic
mechanisms,
picture,
differential
diagnosis
tools.
Alongside
this,
it
summarizes
compares
main
recommendations
from
principal
issued
by
2017
Hemochromatosis
International
Meeting,
American
College
Gastroenterology,
European
Association
Study
Liver,
Molecular
Genetics
Quality
Network,
DUTCH
guidelines,
British
Society
Haematology.
Summarizing
tables
quick
consultation
provided.
International Journal of Medical Sciences and Pharma Research,
Journal Year:
2024,
Volume and Issue:
10(4), P. 44 - 49
Published: Dec. 15, 2024
The
Mentzer
Index
is
a
widely
used
hematological
tool
for
differentiating
between
iron
deficiency
anemia
and
thalassemia,
especially
in
resource-limited
settings
where
advanced
diagnostic
options
may
be
unavailable.
Calculated
as
the
ratio
of
mean
corpuscular
volume
(MCV)
to
red
blood
cell
(RBC)
count,
it
provides
quick
accessible
method
screening.
For
values
over
13,
more
likely,
while
below
13
typically
indicate
thalassemia.
This
simplicity
makes
advantageous
primary
healthcare
community
health
settings,
supporting
early
detection
intervention
at-risk
populations,
including
pregnant
women
children.
Despite
its
usefulness,
has
limitations,
reduced
specificity
accuracy
cases
coexisting
types,
variations
age,
ethnic
differences.
Factors
such
chronic
inflammation,
pregnancy-induced
hemodilution,
concurrent
conditions
can
alter
MCV
RBC
values,
potentially
skewing
index
leading
misclassification.
Additionally,
standard
cut-off
value
not
universally
apply
all
highlighting
need
localized
studies
validate
diverse
demographic
clinical
groups.
Moreover,
reliant
on
accurate
laboratory
results,
which
challenging
low-resource
with
limited
access
quality-controlled
equipment.
Keywords:
Index,
detection,
maternal
health,
anemia,
diagnosis,
pregnancy
complications
International Journal of Medical Sciences and Pharma Research,
Journal Year:
2024,
Volume and Issue:
10(4), P. 39 - 43
Published: Dec. 15, 2024
Anemia
during
pregnancy
is
a
significant
public
health
concern
that
affects
substantial
proportion
of
women
globally,
with
iron
deficiency
anemia
being
the
most
prevalent
form.
Effective
early
diagnosis
and
intervention
are
crucial
to
prevent
adverse
outcomes
for
both
mothers
infants.
The
Mentzer
Index,
simple
calculation
derived
from
mean
corpuscular
volume
(MCV)
red
blood
cell
(RBC)
count,
serves
as
useful
tool
differentiate
between
thalassemia,
thereby
guiding
appropriate
treatment
strategies.
By
categorizing
type
anemia,
healthcare
providers
can
more
accurately
assess
need
supplementation,
which
essential
managing
but
may
not
be
beneficial
in
cases
thalassemia.
Index
has
gained
recognition
its
ease
use,
especially
resource-limited
settings
where
access
advanced
laboratory
diagnostics
restricted.
With
straightforward
calculation,
it
allows
rapid
screening
pregnant
presenting
symptoms.
This
index
only
aids
timely
also
supports
targeted
interventions,
ensuring
supplementation
administered
those
who
truly
it.
approach
minimizes
risk
complications
associated
unnecessary
individuals
thalassemia
or
other
forms
highlighting
importance
accurate
diagnostic
tools
maternal
care.
Keywords:
Anemia,
Pregnancy,
Iron
Supplementation,
Deficiency,
Thalassemia,
Hematological
Indices,
Maternal
Health
International Journal of Medical Sciences and Pharma Research,
Journal Year:
2024,
Volume and Issue:
10(4), P. 50 - 55
Published: Dec. 15, 2024
Thalassemia
traits
present
significant
challenges
during
pregnancy,
often
leading
to
complications
such
as
anemia
and
adverse
maternal
fetal
outcomes.
Early
identification
of
carriers
is
essential
for
managing
these
risks
providing
appropriate
care.
This
review
article
examines
the
Mentzer
Index,
a
straightforward
cost-effective
tool
derived
from
complete
blood
count
(CBC)
parameters,
which
can
effectively
screen
thalassemia
in
pregnant
women.
By
calculating
ratio
mean
corpuscular
volume
(MCV)
red
cell
(RBC)
count,
Index
serves
valuable
first-line
screening
measure,
facilitating
timely
referrals
further
diagnostic
testing.
The
relevance
early
detection
underscored
by
need
informed
reproductive
choices
tailored
management
strategies.
Recognizing
allows
healthcare
providers
monitor
affected
women
closely
implement
interventions,
ultimately
improving
health
Furthermore,
easily
applicable
various
clinical
settings,
particularly
resource-limited
environments
where
access
advanced
laboratory
testing
may
be
limited.
Keywords:
Thalassemia,
anemia,
screening,
health,
carrier
detection.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Anemia
is
a
prevalent
complication
of
chronic
kidney
disease
(CKD)
and
associated
with
increased
mortality
reduced
health-related
quality
life.
The
iron-rich
protein
hemoglobin,
which
the
body
utilizes
to
carry
oxygen,
deteriorates
in
anemia.
Because
hemoglobin
that
contains
iron,
disturbances
iron
homeostasis
can
lead
iron-deficiency
anemia
(IDA).
CKD
frequently
results
anemia,
linked
poor
prognosis.
Nevertheless,
whether
per
se
or
other
comorbidities
are
reason
for
this
connection
remains
unclear.
Uncertainty
surrounds
distinct
forms
IDA
forecast
outcomes.
Physicians,
nurse
practitioners,
physician
assistants,
registered
nurses
work
as
team
manage
patients
CKD.
Individuals
benefit
from
involvement
different
specialties
along
treatment
continuum,
dietitians/nutritionists
play
significant
role
enhancing
management
through
multidisciplinary
care.
This
literature
review
aims
deliver
comprehensive
overview
CKD,
concentrating
on
its
diagnosis.
It
addresses
pathophysiology,
complications
deficiency,
available
diagnostic
tests
Furthermore,
we
analyze
has
contributed
developing
current
practice
guidelines
treating
encouraging
collaboration
managing
Turkish Journal of Internal Medicine,
Journal Year:
2025,
Volume and Issue:
7(1), P. 22 - 27
Published: Jan. 28, 2025
Background
Anaemia
is
defined
by
the
World
Health
Organization
(WHO)
as
a
hemoglobin
value
below
13
g/dL
in
men
and
12
women.
It
serious
public
health
problem
that
can
significantly
affect
quality
of
life.
Methods
Our
study,
whose
universe
consists
family
physicians
who
actively
work
centers
Rize
province,
was
conducted
2021.
After
being
informed
about
our
81
agreed
to
participate
voluntarily
were
included.
Results
research
cross-sectional
descriptive
type
research.
A
20-question
survey
prepared
scanning
literature
presented
data
collection
tool.
While
73
(90.1%)
participants
are
general
practitioners,
8
(8.9%)
medicine
specialists.
The
rate
correctly
knowing
ferritin
diagnose
iron
deficiency
anemia
patient
without
acute
infection
70.4%
(n:
57).
diagnosis
anemia,
recommended
gastrointestinal
system
screening
39.5%
32)
all
87.7%
71)
postmenopausal
recommending
treatment
for
3-6
months
after
level
returned
normal
93.8%
76).
Conclusion
Based
on
we
obtained,
it
seen
physicians’
knowledge
management
insufficient,
there
deficiencies
processes.
For
this
reason,
interactive,
applied
training
programs
should
be
organized.
Non-IgE-mediated
food
allergy
encompasses
a
wide
spectrum
of
allergic
disorders
ranging
from
mild
to
severe
presentations,
including
protein-induced
proctocolitis,
enterocolitis
syndrome,
and
enteropathy.
Other
gastrointestinal
symptoms
such
as
constipation
gastroesophageal
reflux
disease
have
not
previously
been
recognised
non-IgE-mediated
in
guideline
publications.
Recently,
two
new
consensus
documents
the
European
Academy
Allergy,
Asthma
Immunology
address
potential
role
allergens
these
disorders,
where
standard
treatment
has
failed,
provide
guidance
for
diagnosis
management
conditions.
Additional
updates
include
World
Allergy
Organisation
on
cow's
milk
allergy,
most
commonly
implicated
allergy.
These
all
help
practitioners
distinguish
between
common
manifestations
infancy
that
are
pathologic
Understanding
diagnostic
criteria
is
vital
prevent
overdiagnosis,
limit
unnecessary
elimination
diets
preserve
breastfeeding.
Conversely,
proper
may
reduce
infants
who
affected.
Therefore,
first
step
establishing
correct
diagnosis,
which
requires
understanding
clinical
presentations
if
needed,
applying
an
appropriate
short-term
diet
observe
symptom
resolution,
followed
by
reintroduction
assess
recurrence.
Once
diagnosed,
removal
trigger
food,
milk,
without
burden
nutrition
risk.
allergies
typically
resolve
early
childhood
with
some
resolving
therefore
reassessment
tolerance
vital.
Management
entails
following
algorithms,
developing
individualised
dietary
plan,
timely
assessment
development
Asian Journal of Dental and Health Sciences,
Journal Year:
2025,
Volume and Issue:
5(1), P. 30 - 33
Published: March 15, 2025
Hematological
health
in
pregnancy
is
crucial
for
ensuring
favorable
maternal
and
fetal
outcomes,
as
often
predisposes
women
to
conditions
like
anemia.
The
Mentzer
Index,
a
diagnostic
ratio
derived
from
routine
complete
blood
count
(CBC)
parameters,
has
proven
valuable
distinguishing
between
iron-deficiency
anemia
(IDA)
thalassemia
traits,
two
prevalent
yet
distinct
causes
of
pregnant
populations.
This
tool's
simplicity
cost-effectiveness
make
it
especially
useful
resource-limited
settings,
offering
practical
approach
early
diagnosis
tailored
management
strategies.
review
highlights
the
role
Index
assessing
hematological
health,
with
focus
on
its
application
differentiating
subtypes.
By
comparing
mean
corpuscular
volume
(MCV)
red
cell
(RBC),
index
provides
an
accessible
preliminary
screening
mechanism.
While
>13
indicates
IDA,
values
<13
suggest
enabling
clinicians
prioritize
further
evaluations,
such
serum
ferritin
levels
or
hemoglobin
electrophoresis.
timely
differentiation
essential
avoiding
inappropriate
treatments,
unwarranted
iron
supplementation
carriers,
which
may
lead
complications
overload.
Keywords:
Health,
Pregnancy,
Iron-Deficiency
Anemia,
Thalassemia
Trait
Asian Journal of Dental and Health Sciences,
Journal Year:
2025,
Volume and Issue:
5(1), P. 40 - 44
Published: March 15, 2025
Anemia
in
pregnancy
is
a
prevalent
condition
that
can
lead
to
severe
complications
for
both
mothers
and
their
fetuses.
Differentiating
between
the
causes
of
anemia,
particularly
iron
deficiency
anemia
(IDA)
thalassemia
traits,
crucial
appropriate
treatment.
The
Mentzer
Index
(MI)
simple,
cost-effective
tool
used
distinguish
these
two
common
microcytic
by
comparing
mean
corpuscular
volume
(MCV)
red
blood
cell
(RBC)
count.
This
review
explores
clinical
utility
MI
screening
programs,
highlighting
its
advantages,
limitations,
potential
role
improving
diagnosis
management.
has
proven
be
an
effective
first-line
diagnostic
tool,
especially
resource-limited
settings
where
advanced
testing
may
not
readily
available.
By
providing
straightforward
method
differentiate
IDA
from
helps
prevent
inappropriate
use
supplements,
which
exacerbate
individuals
with
thalassemia.
Additionally,
simplicity
allows
incorporation
into
routine
prenatal
care,
efficiency
programs
facilitating
early
intervention.
Despite
benefits,
including
reduced
accuracy
due
physiological
changes
mixed
anemia.
Keywords:
Index,
screening,
utility,
Asian Journal of Dental and Health Sciences,
Journal Year:
2025,
Volume and Issue:
5(1), P. 20 - 24
Published: March 15, 2025
Anemia
during
pregnancy
is
a
prevalent
concern,
with
iron
deficiency
anemia
(IDA)
and
thalassemia
trait
(TT)
being
two
common
causes.
Differentiating
between
these
conditions
crucial
for
effective
management,
as
IDA
requires
supplementation,
while
TT
does
not.
The
Mentzer
Index
(MI)
simple,
cost-effective
tool
used
to
distinguish
by
analyzing
the
mean
corpuscular
volume
(MCV)
red
blood
cell
(RBC)
count.
This
review
explores
usefulness
of
in
assessing
pregnant
women,
its
clinical
applications,
benefits,
limitations
practice.
provides
quick
efficient
means
diagnosing
types
calculating
ratio
MCV
RBC.
A
value
below
13
typically
suggests
trait,
higher
points
anemia.
In
pregnancy,
where
due
increased
demands,
serves
an
essential
guide
treatment
decisions.
By
helping
clinicians
avoid
unnecessary
supplementation
women
thalassemia,
it
reduces
risk
complications
such
overload,
thereby
improving
patient
outcomes.
Keywords:
Anemia,
Pregnant
Women,
Index,
Iron
Deficiency,
Thalassemia
Asian Journal of Dental and Health Sciences,
Journal Year:
2025,
Volume and Issue:
5(1), P. 45 - 49
Published: March 15, 2025
Education
is
very
important
to
women
and
girls
who
are
at
the
greatest
risk
of
contracting
HIV
virus.
However,
more
emphasis
needed
look
information
on
how
education
improves
transmission
among
also
reduces
inequalities
gender
roles
which
able
increase
infection
rates.
There
a
growing
evidence
that
significant
proportion
postpone
first
intercourse,
protect
themselves
against
AIDS
through
safer
sex
practices
advocate
condom
use
in
combination
with
regular
testing
an
effective
sexuality
curriculum.
Additionally,
as
have
greater
control
over
their
sexual
reproductive
health
less
likely
engage
activities
expose
them
HIV,
promotes
equality,
crucial
lowering
risk.
provides
complete
response
epidemic
by
tackling
underlying
factors
contribute
susceptibility,
including
poverty,
gender-based
violence,
early
marriage.
Girls
receive
capable
fending
forceful
exploitative
circumstances
may
HIV.
Keywords:
prevention,
women’s
education,
adolescent
health,
empowerment