Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review DOI
Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Henrique Spaulonci Silveira

et al.

Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: 239(11)

Published: July 22, 2024

The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its function can lead to various diseases. ER stress triggers an adaptive response called the unfolded (UPR), which either restore cellular homeostasis or induce cell death. Melatonin, a safe multifunctional compound, shows promise controlling could be valuable therapeutic agent managing UPR. By regulating mitochondrial functions, melatonin helps maintain via reduction of oxidative stress, inflammation, apoptosis. Melatonin directly indirectly interfere with ER-associated sensors downstream targets UPR, impacting death, autophagy, molecular repair, among others. Crucially, this review explores mechanistic role on diseases including liver damage, neurodegeneration, reproductive disorders, pulmonary disease, cardiomyopathy, insulin resistance, renal dysfunction, cancer. Interestingly, while it alleviates burden most pathological contexts, paradoxically stimulate cancer cells, highlighting intricate involvement homeostasis. With numerous successful studies using vivo vitro models, continuation clinical trials imperative fully explore melatonin's potential these conditions.

Language: Английский

Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway DOI

Xiaodi Fu,

Qi Zhang, Yuhang Chen

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

1
Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment DOI
Gang Xiao, Jiabin Zhang,

Tong Lin

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Language: Английский

Citations

1
Protective role of sulforaphane in lipid metabolism-related diseases DOI
Lingfeng Zhao, Jiahuan Li, Yiping Dang

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 17, 2025

Language: Английский

Citations

1
Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases DOI Creative Commons

Shaojun Zhou,

Kaiwen Cheng, Yi‐Jen Peng

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107332 - 107332

Published: July 30, 2024

The endoplasmic reticulum (ER) plays a pivotal role in protein folding and secretion, Ca

Language: Английский

Citations

7
Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review DOI
Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Henrique Spaulonci Silveira

et al.

Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: 239(11)

Published: July 22, 2024

The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its function can lead to various diseases. ER stress triggers an adaptive response called the unfolded (UPR), which either restore cellular homeostasis or induce cell death. Melatonin, a safe multifunctional compound, shows promise controlling could be valuable therapeutic agent managing UPR. By regulating mitochondrial functions, melatonin helps maintain via reduction of oxidative stress, inflammation, apoptosis. Melatonin directly indirectly interfere with ER-associated sensors downstream targets UPR, impacting death, autophagy, molecular repair, among others. Crucially, this review explores mechanistic role on diseases including liver damage, neurodegeneration, reproductive disorders, pulmonary disease, cardiomyopathy, insulin resistance, renal dysfunction, cancer. Interestingly, while it alleviates burden most pathological contexts, paradoxically stimulate cancer cells, highlighting intricate involvement homeostasis. With numerous successful studies using vivo vitro models, continuation clinical trials imperative fully explore melatonin's potential these conditions.

Language: Английский

Citations

6