Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Journal of Pain Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 3333 - 3343

Published: Oct. 1, 2021

Purpose: Neuroimaging studies on migraine have revealed structural and functional alterations in the hippocampus, a region involved pain processing stress response. This study was designed to investigate whether effective connectivity of this is disrupted relates chronicity disease. Patients Methods: In 39 episodic (EM) patients, 17 chronic (CM) 35 healthy controls, we investigated differences directional influences between hippocampus rest brain by combining resting-state magnetic resonance imaging Granger causality analysis (GCA), with bilateral as seed regions. The associations clinical variables were also examined. Results: Comparing each patient group control group, found increased decreased negative influence exerted visual areas right dorsolateral prefrontal cortex (dlPFC), respectively. showed positive posterior insula medial (mPFC), well left cerebellum CM patients relative EM controls. Furthermore, across all frequency exhibited association causal from mPFC cerebellum, Conclusion: Migraine abnormal multiple regions sensory cognitive pain. Disrupted dlPFC common features patients. Directional may be useful biomarkers for assessing frequency. Keywords: migraine, connectivity, resting-state,

Language: Английский

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Intrinsic functional connectivity in the default mode network predicts mnemonic discrimination: A connectome‐based modeling approach

Hippocampus, Journal Year: 2021, Volume and Issue: 32(1), P. 21 - 37

Published: Nov. 25, 2021

Abstract The ability to distinguish existing memories from similar perceptual experiences is a core feature of episodic memory. This often examined using the mnemonic similarity task in which people discriminate studied objects perceptually lures. Studies neural basis such discrimination have mostly focused on hippocampal function and connectivity. However, default mode network (DMN) connectivity may also support discrimination, given that DMN includes hippocampus, its supports many aspects Here, we used connectome‐based predictive modeling identify associations between intrinsic discrimination. We leveraged wide range abilities across healthy younger older adults facilitate this approach. Resting‐state functional predicted outside MRI scanner, especially among prefrontal temporal regions including several regions. relationship was stronger for than adults, primarily temporal–prefrontal novel established here are consistent with mounting evidence broader cortical networks hippocampus They suggest age‐related disruptions undermine extent ability. study provides first indication how properties

Language: Английский

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Hippocampal vascularization patterns exert local and distant effects on brain structure but not vascular pathology in old age

Brain Communications, Journal Year: 2021, Volume and Issue: 3(3)

Published: June 3, 2021

Abstract The hippocampus within the medial temporal lobe is highly vulnerable to age-related pathology such as vascular disease. We examined hippocampal vascularization patterns by harnessing ultra-high resolution of 7 Tesla magnetic resonance angiography. Dual-supply hemispheres with a contribution anterior choroidal artery blood supply were distinguished from single-supply ones sole dependence on posterior cerebral artery. A recent study indicated that dual related preserved cognition and structural integrity in old age Here, we regional specificity these benefits at level sub-regions hemispheres. In cross-sectional an older cohort 17 patients small vessel disease (70.7 ± 9.0 years, 35.5% female) 27 controls (71.1 8.2 44.4% female), demonstrate differences grey matter volumes pattern specifically observed entorhinal cortex. These regions especially bigger dual-supply hemispheres, but also seemed benefit contralateral supply. further show total greater people least one hemisphere, indicating has more far-reaching implications beyond lobe. mediation analysis identified mediator global cognition. However, our analyses multiple neuroimaging markers for did not reveal any evidence augmented conveys resistance nor resilience against pathology. propose might contribute maintaining brain preserving despite degeneration. As such, binary could have major structure function ageing dementia independent pathology, while presenting simple framework potential applicability clinical setting.

Language: Английский

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Executive Function Predicts Older Adults’ Lure Discrimination Difficulties on the Mnemonic Similarity Task

The Journals of Gerontology Series B, Journal Year: 2023, Volume and Issue: 78(10), P. 1642 - 1650

Published: June 18, 2023

Older adults often have difficulty remembering the details of recently encountered objects. We previously found this with Mnemonic Similarity Task (MST). Surprisingly, older adults' MST Lure Discrimination Index (LDI) was significantly correlated visual acuity but not memory or executive function. Here we ran a replication new, larger samples young (N = 45) and 70). then combined original adult 108) to critically examine relative contributions acuity, memory, function composite scores LDI performance using dominance analysis. This provided, our knowledge, first direct statistical comparison all 3 these factors their interactions on LDI. Participants completed battery assessing examined age group differences in new (i.e., replication) performed multiple regression analysis sample. Consistent previous findings, showed poorer preserved item recognition. both acuity. In sample, composites predicted LDI, indicated that most important predictor. may be by These should considered when interpreting performance.

Language: Английский

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Effects of prior knowledge on brain activation and functional connectivity during memory retrieval

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 22, 2023

Previous studies have shown that the ventral medial prefrontal cortex (vmPFC) plays an important role in schema-related memory. However, there is intensive debate to what extent activation of subregions hippocampus involved retrieving In addition, it unclear how functional connectivity (FC) between vmPFC and hippocampus, as well with other regions, are modulated by prior knowledge (PK) during memory retrieval over time. To address these issues, participants learned paragraphs described features each unfamiliar word from familiar categories (i.e., high low PK conditions) 20 min, 1 day, week before test. They then performed a recognition task judge whether sentences were old scanner. The results showed anterior-medial (amHPC) cluster was stronger when (vs. low) correctly retrieved. posterior (pHPC) cluster, vmPFC, new rejected CR trials), whereas anterior-lateral (alHPC) opposite. FC amHPC perirhinal cortex/inferior temporal gyrus condition, alHPC, thalamus frontal regions opposite for trials. This study highlighted different brain networks, which associated cognitive control responsible information PK.

Language: Английский

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