The Effect of Segmentation Method on Medial Temporal Lobe Subregion Volumes in Aging DOI Creative Commons
Negar Mazloum‐Farzaghi, Morgan D. Barense, Jennifer D. Ryan

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(15)

Published: Oct. 15, 2024

ABSTRACT Early stages of Alzheimer's disease (AD) are associated with volume reductions in specific subregions the medial temporal lobe (MTL). Using a manual segmentation method—the Olsen–Amaral–Palombo (OAP) protocol—previous work healthy older adults showed that grey matter volumes MTL were lower scores on Montreal Cognitive Assessment (MoCA), suggesting atrophy may occur prior to diagnosis mild cognitive impairment, condition often progresses AD. However, current “gold standard” methods labour intensive and time consuming. Here, we examined utility Automatic Segmentation Hippocampal Subfields (ASHS) detect volumetric differences who varied status as determined by MoCA. We trained ASHS OAP protocol create ASHS‐OAP atlas then how well automated replicated segmentation. Volumetric measures obtained from also contrasted against those ASHS‐PMC atlas, widely used provided team. The pattern results was similar between for anterolateral entorhinal cortex perirhinal cortex, is viable alternative detecting group based status. Although produced varying most regions interest, they both identified early signs neurodegeneration CA 2 /CA 3 /DG marginal cortex. Our findings highlight but still underscore need unified harmonized atlas.

Language: Английский

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Reduced Hippocampal Subfield Volumes, and Word Reading DOI Creative Commons
H. J. Yang, Jonathan D. Cohen, David Pagliaccio

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 72, P. 101508 - 101508

Published: Jan. 11, 2025

Reading difficulties and exposure to air pollution are both disproportionately high among youth living in economically disadvantaged contexts. Critically, variance reading skills higher socioeconomic status (SES) contexts largely derives from genetic factors, whereas environmental factors explain more of the lower SES Although research has focused closely on psychosocial environment, little focus been paid effects chemical environment. In this study, we measured prenatal a common pollutant, polycyclic aromatic hydrocarbons (PAH), via presence (versus absence) PAH-DNA adducts maternal blood during third trimester pregnancy. We examined impact PAH adolescent hippocampal subfield volume word sample followed prospectively since birth (N = 165). Compared those without exposure, with detectable 63) exhibited significantly smaller volumes (CA2/3 subfield, t -2.413, p < .05), which was associated worse pseudoword (t 2.346, .05). Exploratory mediation analyses showed significant effect through CA2/3 vol (p .028), suggesting that affects downstream ability.

Language: Английский

Citations

1
Functions of the Human Hippocampus DOI
Daniel N. Barry, Eleanor A. Maguire

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 605 - 648

Published: Jan. 1, 2025

Abstract This chapter describes the journey of signals once they enter brain, and roles played by human hippocampus in their processing. includes perception, short-term maintenance information, replay, consolidation, how representations are transformed or lost over time. The reconstruction during retrieval is then considered, along with other flexible applications hippocampal such as future planning, imagination, navigating through physical, conceptual social space, decision making. Coming full circle, we outline prior experiences influence subsequent attention memory. ends discussing theories whether can account for extant data, identifying where knowledge gaps remain, might be bridged using new technologies.

Language: Английский

Citations

0
Morphometry of medial temporal lobe subregions using high‐resolution T2‐weighted MRI in ADNI3: Why, how, and what's next? DOI Creative Commons
Paul A. Yushkevich,

Ranjit Ittyerah,

Yue Li

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(11), P. 8113 - 8128

Published: Sept. 16, 2024

Abstract This paper for the 20th anniversary of Alzheimer's Disease Neuroimaging Initiative (ADNI) provides an overview magnetic resonance imaging (MRI) medial temporal lobe (MTL) subregions in ADNI using a dedicated high‐resolution T2‐weighted sequence. A review work that supported inclusion this modality into Phase 3 is followed by brief description MTL and analysis protocols summary studies have used these data. supplemented new study uses novel surface‐based tools to characterize neurodegeneration across biomarker‐defined AD stages. reveals pattern spreading cortical thinning associated with increasing levels tau pathology presence elevated amyloid beta, apparent epicenters transentorhinal region inferior hippocampal subfields. The concludes outlook 4. Highlights As 3, protocol includes MRI scan optimized subfields subregions. These scans are processed core obtain automatic segmentations derive morphologic measurements. More detailed granular examination response disease progression achieved applying modeling techniques. Surface‐based gray matter loss spatially expanding patterns advancing stages (AD), as defined based on positron emission tomography biomarkers accordance recently proposed criteria. closely align post mortem literature spread pathological AD, supporting role beta driver neurodegeneration.

Language: Английский

Citations

3
The Effect of Segmentation Method on Medial Temporal Lobe Subregion Volumes in Aging DOI Creative Commons
Negar Mazloum‐Farzaghi, Morgan D. Barense, Jennifer D. Ryan

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(15)

Published: Oct. 15, 2024

ABSTRACT Early stages of Alzheimer's disease (AD) are associated with volume reductions in specific subregions the medial temporal lobe (MTL). Using a manual segmentation method—the Olsen–Amaral–Palombo (OAP) protocol—previous work healthy older adults showed that grey matter volumes MTL were lower scores on Montreal Cognitive Assessment (MoCA), suggesting atrophy may occur prior to diagnosis mild cognitive impairment, condition often progresses AD. However, current “gold standard” methods labour intensive and time consuming. Here, we examined utility Automatic Segmentation Hippocampal Subfields (ASHS) detect volumetric differences who varied status as determined by MoCA. We trained ASHS OAP protocol create ASHS‐OAP atlas then how well automated replicated segmentation. Volumetric measures obtained from also contrasted against those ASHS‐PMC atlas, widely used provided team. The pattern results was similar between for anterolateral entorhinal cortex perirhinal cortex, is viable alternative detecting group based status. Although produced varying most regions interest, they both identified early signs neurodegeneration CA 2 /CA 3 /DG marginal cortex. Our findings highlight but still underscore need unified harmonized atlas.

Language: Английский

Citations

1