The Retrosplenial Cortical Role in Delayed Spatial Alternation.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Abstract The retrosplenial cortex (RSC) plays an important role in spatial cognition. RSC neurons exhibit a variety of firing patterns and lesion studies have found that the is necessary for working memory tasks. However, little known about how might encode during delay period. In present study, we trained control rats with excitotoxic lesions on alternation task varying durations separate group rats, recorded neuronal activity as performed task. We significantly impaired performance, particularly at longest duration. also exhibited reliably different throughout periods preceding left right trials, consistent signal. These differential were absent errors. many large spike rate leading up to start trial. Many these trial responses differentiated suggesting they could play priming ‘go left’ or right’ behavioral responses. Our results suggest represent critical information underlies memory.

Language: Английский

The retrosplenial cortical role in delayed spatial alternation

Neurobiology of Learning and Memory, Journal Year: 2024, Volume and Issue: 216, P. 108005 - 108005

Published: Nov. 13, 2024

Language: Английский