Five-membered ring systems with O and N atoms DOI
Franca M. Cordero, Donatella Giomi, Fabrizio Machetti

et al.

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 351 - 382

Published: Jan. 1, 2023

Language: Английский

The Aldol Reaction: Organocatalytic Approach DOI
Chao‐Shan Da, Zhi‐Hong Du, Pei Wang

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in Transition Metal Catalysis and Organocatalysis Approaches towards Asymmetric Synthesis of β-Amino Acid Derivatives DOI

Farrukh Sajjad,

Shuyue Zhang, Ming‐Hua Xu

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Abstract The stereoselective synthesis of β-amino acids has attracted major attention among the synthetic community in recent years. This review provides an overview important advances chiral acid over past decade. It covers development enantioselective methods using transition-metal complexes or organocatalysts, mainly including catalytic asymmetric hydrogenation, Mannich reaction, multicomponent reactions diazo compounds, and conjugate addition. Additionally, optically active by other approaches are also summarized. 1 Introduction 2 Strategies towards Asymmetric Synthesis β-Amino Acids 2.1 Hydrogenation 2.2 Reaction 2.3 Conjugate Addition 2.4 Multicomponent Reactions 2.5 Miscellaneous 2.5.1 from Chiral Amines 2.5.2 Isoxazolidinones 2.5.3 Other Methodologies 3 Summary Outlook

Language: Английский

Citations

2
Multifaceted Behavior of 2‐Cyanobenzaldehyde and 2‐Acylbenzonitriles in the Synthesis of Isoindolinones, Phthalides and Related Heterocycles DOI Creative Commons

Mohammad Sadeq Mousavi,

Antonia Di Mola, António Massa

et al.

European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 26(24)

Published: May 4, 2023

Abstract 2‐Cyanobenzaldehye (also called 2‐formylbenzonitrile) and related 2‐acylbenzonitriles belong to a class of bifunctional aromatic compounds that emerged as useful starting materials in developing efficient cascade‐type reactions leading different heterocyclic compounds. The variety sometimes unpredictable mechanisms rise from these structurally simple renders this unique afford, through divergent cascade reactions, heterocycles like isoindolinones, phthalides known with the name isobenzofuranones), imidates, less extent isoindolin‐1‐imine, six‐ seven‐membered heterocycles, porphyrins, also asymmetric way exploiting organocatalytic activation modes. To give picture, chemistry can be associated Goldberg variations which stem common motive pressing surprising way. In Review, emphasis is given synthetic methods for access substituted 2‐cyanobenzaldehydes allowed enlarge scope described reactions.

Language: Английский

Citations

6
Chiral Quaternary Ammonium Salt‐Catalyzed Enantioselective Addition Reactions of Hydantoins DOI Creative Commons

Katharina Röser,

Lucas Prameshuber,

Sajid Jahangir

et al.

Helvetica Chimica Acta, Journal Year: 2023, Volume and Issue: 107(3)

Published: Dec. 29, 2023

Abstract We herein report a protocol for the asymmetric 1,4‐addition of hydantoins to various Michael acceptors by utilizing Cinchona alkaloid‐based chiral quaternary ammonium salt catalysts. Various products were obtained with moderate good enantioselectivities and accompanying computational investigations helped identify key interactions responsible observed selectivity. DFT calculations along non‐covalent interaction plots reveal presence numerous stabilizing non‐classical hydrogen bonding other between hydantoin molecule in C−C bond forming transition states leading formation products. In addition, first proof‐of‐concept an analogous a‐sulfanylation reaction, albeit poor selectivity, is reported as well.

Language: Английский

Citations

4
Five-membered ring systems with O and N atoms DOI
Franca M. Cordero, Donatella Giomi, Fabrizio Machetti

et al.

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 351 - 382

Published: Jan. 1, 2023

Language: Английский

Citations

0