Safety Monitoring of COVID-19 Vaccines in Persons with Prior SARS-CoV-2 Infection: A European Multi-Country Study

Vaccines, Journal Year: 2024, Volume and Issue: 12(3), P. 241 - 241

Published: Feb. 26, 2024

In all pivotal trials of COVID-19 vaccines, the history previous SARS-CoV-2 infection was mentioned as one main exclusion criteria. absence clinical trials, observational studies are primary source for evidence generation. This study aims to describe patient-reported adverse drug reactions (ADRs) following first vaccination cycle, well administration booster doses different vaccine brands, in people with prior infection, compared infection-free matched cohorts vaccinees. A web-based prospective conducted collecting vaccinee-reported outcomes through electronic questionnaires from eleven European countries period February 2021–February 2023. baseline questionnaire and up six follow-up collected data on vaccinee’s characteristics, solicited unsolicited reactions. Overall, 3886 902 vaccinees having received dose or a dose, respectively, were included analysis. After reported at least ADR higher frequency than those without (3470 [89.6%] vs. 2916 [75.3%], 614 [68.2%] 546 [60.6%], respectively). On contrary side, after second lower frequency, controls (1443 [85.0%] 1543 [90.9%]). The median time onset recovery similar across cohorts. individuals who Vaxzevria Spikevax doses. serious ADRs low Data this large-scale could be used inform likelihood effects based their age, sex, type administered. line safety profile vaccines also confirmed infection.

Language: Английский

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Comparison of Biological, Pharmacological Characteristics, Indications, Contraindications, Efficacy, and Adverse Effects of Inactivated Whole-Virus COVID-19 Vaccines Sinopharm, CoronaVac, and Covaxin: An Observational Study

Vaccines, Journal Year: 2023, Volume and Issue: 11(4), P. 826 - 826

Published: April 11, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging viral zoonotic illness that has developed a distinctive and threatening situation globally. Worldwide, many vaccines were introduced to fight against the COVID-19 pandemic. The present study aims compare bio-pharmacological characteristics, indications, contraindications, efficacy, adverse effects of inactivated whole-virus vaccines, Sinopharm, CoronaVac, Covaxin. Initially, 262 documents 6 international organizations selected. Finally, 41 articles, fact sheets, included. data recorded from World Health Organization (WHO), Food Drug Administration (FDA) USA, Web Science, PubMed, EMBASE, Scopus. results demonstrated these three Covaxin, received emergency approval FDA/WHO, all are beneficial for prevention Sinopharm vaccine been recommended during pregnancy people age groups, CoronaVac Covaxin over 18 years older. These have intramuscular doses 0.5 mL each, with 3–4 week interval. can be stored in refrigerator at +2 +8 °C. common pain injection site, redness, fatigue, headache, myalgias, general lethargy, body ache, arthralgia, nausea, chills, fever, dizziness. overall mean efficiency disease 73.78% 70.96% 61.80% In conclusion, However, evidence suggests impact slightly better than

Language: Английский

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Frequency of COVID‐19 vaccine side effects and its associated factors among the vaccinated population of Pakistan: A cross‐sectional study

Health Science Reports, Journal Year: 2023, Volume and Issue: 6(1)

Published: Jan. 1, 2023

Abstract Background Coronavirus disease 2019 (COVID‐19) vaccine side effects have an important role in the hesitancy of general population toward administration. Therefore, this study was conducted to document COVID‐19 our population. Materials and Methods An online survey‐based, cross‐sectional carried out from September 1, 2021, October among public. The questionnaire included participants’ sociodemographic data, type vaccine, comorbidities, previous infection, assessment reported by them. Results majority participants were <20 years age (62.2%), females (74.9%), belonged educational sector (58.1%), residents Sindh (65.7%), previously unaffected infection (73.3%). Sinovac (38.7%) followed Sinopharm (30.4%) Moderna (18.4%) administered more frequently. Commonly injection site pain (82%), myalgia (55%), headache (46%), fatigue/malaise (45%), fever (41%). Vaccine likely be with first dose as compared second dose. On regression analysis, factors associated occurrence younger (odds ratio [OR]: 6.000 [2.065–17.431], p < 0.001), female gender (OR: 2.373 [1.146–4.914], = 0.020), marital status 0.217 [0.085–0.556], graduate level education 0.353 [0.153–0.816], 0.015), occupation being either retired, freelancers, or social workers 0.310 [0.106–0.909]), 0.033). Previous ( 0.458) comorbidities found unrelated 0.707) effects. Conclusion overall prevalence local quite higher than systemic ones. Further large‐scale studies on safety are required strengthen public confidence vaccination drive.

Language: Английский

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Comparing COVID-19 literacy and vaccine hesitancy among health care workers, including oral health professionals, in Japan

BDJ Open, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 4, 2025

Language: Английский

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Trajectory of COVID-19 vaccine hesitancy post-vaccination and public’s intention to take booster vaccines: A cross-sectional analysis

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(2)

Published: June 23, 2023

Vaccine hesitancy (VH) is not a new phenomenon in Pakistan and regarded as one of the primary causes unsatisfactory vaccination campaigns. This study determined post-vaccination COVID−19 VH, factors influencing vaccine uptake, public's intent to receive booster vaccinations. A cross-sectional was conducted among adult population Lahore, Pakistan. Participants were recruited via convenience sampling between March May 2022. SPSS version 22 used for data analysis. total 650 participants included (age = 28.1 ± 9.7 years; male-to-female ratio nearly 1: 1). The majority received Sinopharm followed by Sinovac vaccine. top three reasons uptake "only vaccinated individuals are allowed at workplace, educational institutes" (Relative importance index (RII) 0.749), people go markets, malls other public places" (RII 0.746), "protect myself from infection" 0.742). mean VH score 24.5 6.2 (95% CI 23.9–24.9), with being pro-vaccines poor economic status significant predictors immunized (p < .05). Acceptance vaccines negatively associated younger age lower level education. Furthermore, pro-vaccine greater likelihood accepting .001). Pakistani continues express toward vaccines. Therefore, aggressive measures must be taken combat community that contribute it.

Language: Английский

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Acceptance to take COVID-19 vaccine and its relation to COVID-19 infection

Italian Journal of Medicine, Journal Year: 2024, Volume and Issue: 18(2)

Published: April 30, 2024

One of the biggest global health threats is vaccine hesitancy and it remains a issue. The speed at which vaccines are developed media misinformation contribute to reluctance. This study examined relationship between acceptance COVID-19 infection. A cross-sectional was used with sample 1388 subjects including students academic staff. Data were collected using self-administered Vaccine Acceptance Behavior questionnaire, has nine dimensions 42 items asks about infection frequency timing. mean behavior scores hesitant low. Low trust in (25.4%) main reason for hesitancy. positively correlated increased rates (P≤0.001). can reduce rates, protect vulnerable populations, aid public efforts control virus.

Language: Английский

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Unraveling the association between vaccine attitude, vaccine conspiracies and self-reported side effects following COVID-19 vaccination among nurses and physicians in Jordan

Vaccine X, Journal Year: 2023, Volume and Issue: 15, P. 100405 - 100405

Published: Nov. 8, 2023

The negative impact of vaccine conspiracies is linked with health behavior. aim the current study was to examine association between attitudes toward booster COVID-19, influenza, and monkeypox (mpox) vaccinations post-COVID-19 side effects, conspiracies, attitude towards mandatory vaccination among nurses physicians in Jordan.

Language: Английский

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Longitudinal Follow-Up Study on the Side Effects of COVID-19 Vaccines: A Telephonic Questionnaire Approach

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Background: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted urgent efforts to develop and deploy effective vaccines. Covishield Covaxin are two prominent vaccines authorized for emergency use; however, concerns regarding their safety persist. Objective: This longitudinal follow-up study aimed comprehensively assess compare the demographic characteristics, frequencies, severities of reported side effects, associations between vaccine type factors among individuals vaccinated with Covaxin. Methods: A telephonic questionnaire was used collect data from who attended vaccination programs January 1, 2021, 2022. Logistic regression analysis performed investigate type, factors, likelihood experiencing effects. Results: recipients exhibited a lower incidence mild flu-like illness (16 cases) post-vaccination infection (55 than (110 98 cases, respectively). However, more cases soreness at injection site (139 did (172 cases). revealed significantly higher odds effects (OR = 1.687, p < 0.001). Age inversely associated 0.982, 0.001), while sex ethnicity also significant associations. Conclusion: provides valuable insights into profiles These findings underscore importance ongoing surveillance evaluation tolerability inform public health policies strategies.

Language: Английский

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Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders

Medical Principles and Practice, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33

Published: Dec. 19, 2024

Although COVID-19 vaccines exhibit diverse side effects, taste and saliva secretory disorders have remained poorly understood despite their negative impact on the overall quality of life. The present study aimed to characterize oral adverse effects following vaccination assess similarities with symptoms in patients. A literature search was conducted databases, including PubMed, LitCovid, Google Scholar, retrieve relevant studies. narrative review indicated that a certain number vaccinated people develop ageusia, dysgeusia, hypogeusia, xerostomia, dry mouth, while they are rare compared symptoms. prevalence varies by country/region such geographical differences may be related type vaccine used. Similar SARS-CoV-2 infection, adversely affects perception salivary secretion females older subjects more frequently than males younger subjects. Their impairments mostly appear withing three days after vaccination, bitter is specifically impaired some cases. Considering share characteristics patients, it speculated spike protein derived from infection pathophysiologically responsible for disorders. This because has potential interact ACE2 expressed cells, produce proinflammatory cytokines, form antiphospholipid antibodies. Our results do not deny advantage but attention should paid post-vaccination addition

Language: Английский

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Adverse Effects of Covid-19 Vaccine; an Observational Studymainly Focusing on the Cutaneous Reactions in Both Genders

Published: April 29, 2023

Objective: COVID-19 caused a deleterious impact on the health care system globally.The roll out of vaccines seems to be only effective way curtail spread disease.The purpose this study is assess dermatological adverse effect post COVID-19vaccination gender basis. Methodology: This was an observational,cross-sectional,questionnaire-based survey conducted in Pakistan.The sample comprises 518 participants. The questionnaire self-designed. trial lasted six months, from August 1, 2022, until January 31, 2023. We used non-probability sampling technique.Dermatological effects like burning pain, redness, rashes, and lymphadenopathy at injection site were recorded.Fever also noted. All participants have received booster shots or double doses any one CCOVID-19 vaccines, such as AstraZeneca, Pfizer, Sinovac, Sinopharm,Pakvac, etc. A p-value less than 0.05 considered statistically significant.Qualitative data reported frequency percentage, quantitativedata standard deviation mean. Results: included subjects, whom 262 males 256 females. mean age male 42.70±14.05 years female 39.04±14.6years with significant difference observed between them (p=0.004). most common complaint among after first pain. 106(40.5%) 132(51.6%) painwith (p=0.011) followed by swelling which 92(35.1%) 120(46.9%) females (p=0.006).Burning 148(57.8%) them(p<0.001). Fever quite commonly both 116(44.3%) 178(69.5%) significantdifference (p<0.001),Likewise 2nd dose vaccination, pain noted 90(34.4%) 124(48.4%) (p=0.001). Moreover, 80(30.5%) malesand (p<0.001). rashes by76(29.0%) 100(39.1%) (p=0.016), significantly associated genders, Conclusion: concluded that pain,redness,rashes,and lymphadenopathywere prevalent side 1st 2ndCOVID-19 vaccination.Furthermore fever majority subjects.In addition higher percentage recorded comparedto males. Keywords: vaccine effects, fever.

Language: Английский

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