Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications
Life,
Journal Year:
2023,
Volume and Issue:
13(11), P. 2213 - 2213
Published: Nov. 16, 2023
Diabetes
mellitus,
a
chronic
metabolic
disorder
characterized
by
hyperglycemia,
presents
formidable
global
health
challenge
with
its
associated
complications.
Adiponectin,
an
adipocyte-derived
hormone,
has
emerged
as
significant
player
in
glucose
metabolism
and
insulin
sensitivity.
Beyond
effects,
adiponectin
exerts
anti-inflammatory,
anti-oxidative,
vasoprotective
properties,
making
it
appealing
therapeutic
target
for
mitigating
diabetic
The
molecular
mechanisms
which
impacts
critical
pathways
implicated
nephropathy,
retinopathy,
neuropathy,
cardiovascular
problems
are
thoroughly
examined
this
study.
In
addition,
we
explore
possible
treatment
options
increasing
levels
or
improving
downstream
signaling.
multifaceted
protective
roles
of
complications
suggest
potential
novel
avenue.
However,
further
translational
studies
clinical
trials
warranted
to
fully
harness
the
management
This
review
highlights
promising
diverse
encourages
continued
research
pivotal
area
diabetes
therapeutics.
Language: Английский
<strong>Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications </strong>
Published: Oct. 12, 2023
Diabetes
mellitus,
a
chronic
metabolic
disorder
characterized
by
hyperglycemia,
presents
formidable
global
health
challenge
with
its
associated
complications.
Adiponectin,
an
adipocyte-derived
hormone,
has
emerged
as
significant
player
in
glucose
metabolism
and
insulin
sensitivity.
Beyond
effects,
adiponectin
exerts
anti-inflammatory,
anti-oxidative,
vasoprotective
properties,
making
it
appealing
therapeutic
target
for
mitigating
diabetic
The
molecular
mechanisms
which
impacts
critical
pathways
implicated
nephropathy,
retinopathy,
neuropathy,
cardiovascular
problems
are
thoroughly
examined
this
study.
In
addition,
we
explore
possible
treatment
options
increasing
levels
or
improving
downstream
signaling.
multifaceted
protective
roles
of
complications
suggest
potential
novel
avenue.
However,
further
translational
studies
clinical
trials
warranted
to
fully
harness
the
management
This
review
highlights
promising
diverse
encourages
continued
research
pivotal
area
diabetes
therapeutics.
Language: Английский
Trauma Burden Affected People with Multiple Sclerosis During SARS-CoV-2 Pandemic
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(8), P. 2665 - 2665
Published: April 13, 2025
Background/Objectives:
Trauma
is
a
psychological
injury
resulting
from
distressing
or
overwhelming
event.
The
SARS-CoV-2
pandemic
has
been
disruptive
and
traumatic
for
many
people
with
multiple
sclerosis
(pwMS).
relationship
between
patient
characteristics
trauma
in
pwMS
during
the
not
yet
thoroughly
explored.
aim
of
this
bicentric
prospective
cohort
study
was
to
analyze
prevalence
development
probable
post-traumatic
stress
disorder
(PTSD)
among
identify
parameters
associated
condition.
Methods:
We
have
assessed
PTSD
before
after
approval
first
vaccines
Germany
using
an
adapted
version
Screening
Questionnaire
(TSQ).
compared
(TSQ
sum
score
≥
6)
those
without
<
regarding
sociodemographic
MS-specific
clinical
characteristics,
polypharmacy
status,
comorbidities,
anxiety/depression
levels,
personality
traits,
mental/physical/social
burden,
general
vaccination
willingness.
Results:
Out
149
included,
8.1%
were
identified
as
having
PTSD.
These
patients
had
significantly
higher
rates
pre-pandemic
abnormal
anxiety
(66.7%
vs.
18.5%,
p
0.001)
depression
scores
(45.5%
12.6%,
=
0.013).
exhibited
distinct
profile,
neuroticism
harm
avoidance
lower
conscientiousness,
cooperativeness,
self-directedness
scores.
They
also
more
likely
report
severe
very
burdens
(p
≤
0.045).
Conclusions:
Medical
social
services
should
be
provided
support
who
experienced
serious
trauma.
concepts
education
procedures
accompanied
by
comprehensive
clear
communication
that
recognizes
individual
risk
factors
addresses
possible
concerns
evidence-based
convincing
arguments.
Language: Английский
Death Anxiety Among Pakistani HCWs: The Role of COVID-19 Vaccine Acceptance and Positive Religious Coping Strategy
OMEGA - Journal of Death and Dying,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 28, 2023
The
mental
health
of
healthcare
workers
(HCWs)
has
been
significantly
impacted
by
the
COVID-19
pandemic.
To
address
this,
spirituality
and
religious
coping
mechanisms
have
suggested
as
a
way
to
maintain
well-being
reduce
anxiety
levels.
Additionally,
vaccination
shown
play
an
essential
role
in
lowering
levels,
including
death
anxiety.
However,
there
is
lack
evidence
on
how
positive
strategies
immunization
affect
fill
this
gap,
study
uses
Pakistani
HCWs
sample.
Language: Английский
Research on Common Mental Disorders in Bangladesh
Published: Jan. 1, 2024
Common
mental
disorders
include
depression
and
anxiety
disorders.
These
conditions
are
among
the
leading
causes
of
disability
morbidity
worldwide.
According
to
recent
National
Mental
Health
Survey,
over
10%
population
Bangladesh
suffers
from
one
these
In
past
decade,
there
has
been
a
significant
increase
in
quality
quantity
published
research
pertaining
CMDs
Bangladesh.
The
global
COVID-19
pandemic
provided
further
impetus
such
efforts.
current
chapter
reviews
existing
on
epidemiology,
pathophysiology,
diagnosis,
management
Bangladesh,
ways
surmount
them.
into
also
assessed,
integration
care
for
primary
or
general
health
is
discussed.
Language: Английский