Cardiac effects and comorbidities of neurological diseases DOI Creative Commons

Busra Ozturk

TURKISH JOURNAL OF MEDICAL SCIENCES, Journal Year: 2024, Volume and Issue: 54(7), P. 1428 - 1437

Published: Dec. 13, 2024

Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These profoundly impact cardiovascular health, prompting an intensified exploration into intricate interconnections between systems. This review synthesizes current insights research on comorbidities associated with major conditions, including stroke, epilepsy, Parkinson's disease, multiple sclerosis (MS), Alzheimer's disease.The sequelae these are multifactorial. For instance, strokes not only predispose individuals to arrhythmia heart failure but also exacerbate pre-existing risk factors. Similarly, epilepsy is autonomic dysregulation elevated sudden cardiac death, underscoring necessity for vigilant monitoring in affected individuals. disease manifests orthostatic hypotension sympathetic denervation, significantly contributing morbidity. Additionally, exhibit dysfunction heightened risk, need proactive management strategies.Mechanistically, conditions disrupt system regulation, incite chronic inflammation, may share genetic susceptibilities, pathology. Effective complexities requires integrative approach includes factor modification, pharmacotherapy, lifestyle interventions, comprehensive patient education.Future directions include identifying novel therapeutic targets, conducting large-scale clinical trials, investigating biomarkers individualize treatment strategies. By addressing multifaceted interactions healthcare providers can optimize care, reducing morbidity mortality this vulnerable population.

Language: Английский

Prevalence of Stroke in People with Multiple Sclerosis DOI Creative Commons

Masoud Etemadifar,

Nahad Sedaghat,

Hussien Sbeity

et al.

International Journal of Preventive Medicine, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 1, 2025

Language: Английский

Citations

0
When Potassium Takes a Break: A Case Series of 3 Cases on Hypokalemic Periodic Paralysis DOI Creative Commons
Yuvraj Kaushal, A Kaur,

P. Goyal

et al.

Clinical Case Reports, Journal Year: 2025, Volume and Issue: 13(5)

Published: April 29, 2025

This case series highlights three SHPP cases with varied triggers, managed potassium supplementation and targeted treatments. Early diagnosis, individualized care, patient education proved vital in preventing recurrence complications, emphasizing the need for clinical vigilance tailored approaches HPP management.

Language: Английский

Citations

0
Risk of stroke under disease modifying therapies for multiple sclerosis: a systematic review DOI Creative Commons
Maria‐Ioanna Stefanou, Aikaterini Theodorou, Annerose Mengel

et al.

Therapeutic Advances in Neurological Disorders, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Background: Epidemiological research indicates a heightened incidence of cerebrovascular disorders among patients with multiple sclerosis (MS). Objectives: The aim the present systematic review was to investigate potential association between disease modifying therapies (DMTs) and risk stroke in MS patient populations. Data sources methods: A literature search performed MEDLINE SCOPUS databases up April 6, 2024, identify randomized-controlled clinical trials (RCT), registry-based cohort-studies, case-series, case-reports reporting on acute ischemic (AIS) or intracerebral hemorrhage (ICH) under different DMTs. Results: Twenty-one studies were included: 1 RCT, 6 cohort studies, 2 case-series 11 case-reports. Overall, DMTs appear reduce patients, DMT exposure linked 50% reduction compared no exposure. Although glatiramer acetate dimethyl fumarate lower stroke, concerns about fingolimod exists due an observed elevated for heart hypertension. Despite absence detected safety alemtuzumab at population level, alemtuzumab-related complications, although rare, signal need vigilance. Similarly, β-interferons have been life-threatening adverse events, comprising thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS). No associations other DMTs, natalizumab teriflunomide, detected; yet, newly approved underrepresented. Conclusion: These findings highlight importance personalizing selection monitoring cardiovascular factors MS. Trial registration: PROSPERO CRD42024534470.

Language: Английский

Citations

0
Neuroimaging biomarkers for predicting stroke outcomes: A systematic review DOI Creative Commons
Elizabeth Gaviria, Awab Hamid Eltayeb Hamid

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(7)

Published: July 1, 2024

Abstract Background and Aims Stroke is a prominent cause of long‐term adult impairment globally significant global health issue. Only 14% stroke survivors achieve full recovery, while 25% to 50% require varying degrees support, over half become dependent. The aftermath brings profound changes an individual's life, with early choices significantly impacting their quality life. This review aims establish the efficacy neuroimaging data in predicting outcomes recovery rates following stroke. Methods A scientific literature search was conducted using Centre Reviews Dissemination (CRD) criteria PRISMA guidelines for combined meta‐narrative systematic quantitative review. methodology involved structured databases like PubMed Cochrane Library, inclusion exclusion identify relevant studies on biomarkers outcome prediction. Data collection utilized Microsoft Edge Zotero plugin, appraisal via CASP checklist. Studies published from 2010 2024, including observational, randomized control trials, case reports, clinical trials. Non‐English incomplete were excluded, resulting identification 11 pertinent articles. extraction emphasized study methodologies, conditions, parameters, biomarkers, aiming provide thorough overview evaluate significance outcomes. Results results this indicate that integrating advanced methods highly successful reperfusion therapies facilitates diagnosis condition assists improving neurological impairments These measures reduce possibility death improve treatment provided patients. Conclusion findings highlight crucial role advancing our understanding post‐stroke patient care.

Language: Английский

Citations

0
Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study DOI Creative Commons

Elyar Alizadeh Najmi,

Zahra Mirzaasgari, Mohammad Reza Motamed

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0314031 - e0314031

Published: Nov. 19, 2024

Background Multiple sclerosis (MS) is characterized by inflammation and demyelination in the central nervous system. Recent studies have suggested a potential association between MS an increased risk of atherosclerosis, systemic vascular disease involving arterial wall thickening. Understanding this relationship crucial, given heightened cardiovascular observed patients. Objective To investigate factors influencing development atherosclerosis patients with multiple (pwMS), focusing on carotid intima-media thickness (CIMT) as marker. Methods 114 pwMS (82 females 32 males) 127 control subjects (57 70 were included. The mean CIMT two groups was compared. Additionally, effects annual relapse rate, EDSS (Expanded Disability Status Scale), duration, treatment type Disease-modifying (DMT) evaluated. Results This study included 241 participants (SD) age 41.13 years (10.93). significantly higher compared to controls ( p < 0.001). Even after adjusting for age, sex, BMI (Body Mass Index), remained group Spearman’s correlation analysis revealed significant associations BMI, score, duration (all 0.05). SPMS (Secondary Progressive Sclerosis) course associated Linear regression identified most predictor 0.001), followed = 0.054). Conclusion demonstrates CIMT. emerged prominent high pwMS, BMI. These findings suggest link risk. Further research warranted explore underlying mechanisms long-term outcomes population.

Language: Английский

Citations

0
Multiple sclerosis and vascular nexus: A systematic review and meta-analysis of incidence and mortality DOI
Imen Ketata, Emna Ellouz

Revue Neurologique, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0
Cardiac effects and comorbidities of neurological diseases DOI Creative Commons

Busra Ozturk

TURKISH JOURNAL OF MEDICAL SCIENCES, Journal Year: 2024, Volume and Issue: 54(7), P. 1428 - 1437

Published: Dec. 13, 2024

Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These profoundly impact cardiovascular health, prompting an intensified exploration into intricate interconnections between systems. This review synthesizes current insights research on comorbidities associated with major conditions, including stroke, epilepsy, Parkinson's disease, multiple sclerosis (MS), Alzheimer's disease.The sequelae these are multifactorial. For instance, strokes not only predispose individuals to arrhythmia heart failure but also exacerbate pre-existing risk factors. Similarly, epilepsy is autonomic dysregulation elevated sudden cardiac death, underscoring necessity for vigilant monitoring in affected individuals. disease manifests orthostatic hypotension sympathetic denervation, significantly contributing morbidity. Additionally, exhibit dysfunction heightened risk, need proactive management strategies.Mechanistically, conditions disrupt system regulation, incite chronic inflammation, may share genetic susceptibilities, pathology. Effective complexities requires integrative approach includes factor modification, pharmacotherapy, lifestyle interventions, comprehensive patient education.Future directions include identifying novel therapeutic targets, conducting large-scale clinical trials, investigating biomarkers individualize treatment strategies. By addressing multifaceted interactions healthcare providers can optimize care, reducing morbidity mortality this vulnerable population.

Language: Английский

Citations

0