Semaglutide and High-Intensity Interval Exercise Attenuate Cognitive Impairment in Type 2 Diabetic Mice via BDNF Modulation

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 480 - 480

Published: May 1, 2025

Background/Objectives: Diabetes frequently leads to cognitive impairment, encompassing issues with memory and executive function, as well depression anxiety. This study examines the impact of high-intensity interval exercise (HIIE) alongside glucagon-like peptide-1 receptor agonist (GLP-1 RA) semaglutide on dysfunction associated diabetes. Methods: Db/db mice were divided into a control group, HIIE combined group metabolic neurobehavioral effects. Cognitive behavioral tests, hippocampal morphology, molecular analyses (APP, BDNF, Aβ, p-Tau, PKA, AMPK) performed. HT22 cells under high glucose treated semaglutide, L-lactate, PKA inhibitor H89, AMPK Compound C validate mechanisms. Results: Over 8 weeks, both improved neuronal morphology performance while reducing in db/db mice. However, current observed no synergistic Both therapies decreased Aβ p-Tau protein levels increased BDNF hippocampus, likely through signaling pathways, respectively. In vitro, conditions exhibited elevated APP expression reduced levels, which could be altered by L-lactate semaglutide. The H89 attenuated increase induced but their combination mitigated this inhibitory effect. suggests that improve function reduce via use did not show anticipated benefits due potential antagonism between pathways. Conclusions: has important implications for designing prescriptions impairment diabetics.

Language: Английский

Hormonal, antioxidant, and body composition differences in national level male athletes: a comparative study of aerobic and anaerobic training

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: May 20, 2025

Competitive athletes exhibit distinct physiological adaptations depending on their sport type and training techniques. These variations influence body composition, hunger-regulating hormones, antioxidant defense mechanisms, which collectively impact performance, recovery, progression. This study aimed to compare serum levels of ghrelin, leptin, glutathione (GSH), interrelationships in national level male engaged aerobic anaerobic sports. Twenty competitive (aged 17-38 years) were evenly divided into (AS) (AnS) sports groups. Body composition-including skeletal muscle mass (SMM), fat-free (FFM), fat (FM), percent (PBF)-was assessed using bioelectrical impedance analysis (BIA). Blood samples collected after 8 h fasting measure GSH levels. Dietary intake was evaluated a 24-h recall. Group differences analyzed the Mann-Whitney U-test, correlations determined Spearman's rank correlation, with statistical significance set at p < 0.05. The AnS group displayed significantly higher SMM FFM compared AS (p 0.05). Ghrelin lower 0.05), while leptin did not differ between Positive observed ghrelin both (r = 0.585, 0.007), dietary protein 0.476, 0.03). Anaerobic exercise enhances mass, supports appetite suppression. Limitations include small sample size reliance Future research should use larger, more diverse explore combined effects. Recommendations incorporating resistance regimens optimize monitoring support defense.

Language: Английский

Acute effect of exercise on appetite‐related factors in males with obesity: A pilot study

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(24)

Published: Dec. 1, 2024

Abstract To investigate the role of appetite‐related factors, including interleukin 6 (IL‐6), irisin, 7 (IL‐7), neuropeptide Y (NPY), and leptin, on appetite perception in males with obesity. Eleven (BMI 35.3 ± 4.2 kg/m 2 , V̇O 2peak 29 3.1 mL/kg/min) participated two experimental trials (MICE: 60 min cycling at 60% ; CTRL: quiet resting) using a crossover design. Appetite parameters, IL‐6, IL‐7, were measured. Additionally, was assessed. IL‐6 concentration increased significantly immediately post‐exercise (95% CI: [2.207–12.192] pg/mL, p = 0.007) remained elevated 1 hour [2.326–11.855] 0.006) compared to CTRL. Irisin also rose [0.084–3.061] ng/mL, 0.039). NPY decreased h [(−20.601) – (−1.380)] ng/L, 0.027). No significant differences observed for IL‐7 ( 0.748, 0.077) leptin 0.285, ). perceptions suppressed [3.407–19.547] mm, 0.008) Sixty minutes MICE irisin concentrations while

Language: Английский