Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3396 - 3407
Published: Jan. 1, 2024
Understanding
the
molecular
mechanism
by
which
periodontal
ligament
(PDL)
is
maintained
uncalcified
between
two
mineralized
tissues
(cementum
and
bone)
may
facilitate
functional
repair
regeneration
of
periodontium
complex,
disrupted
in
context
diseases.
However,
research
that
explores
control
type
I
collagen
(COL
I)
mineralization
fails
to
clarify
detailed
regulating
spatial
mineralization,
especially
complex.
In
present
study,
decorin
(DCN),
characterized
as
abundant
PDL
region
rare
tissues,
was
hypothesized
be
a
key
regulator
mineralization.
The
circular
dichroism
results
confirmed
DCN
regulated
secondary
structure
COL
I,
surface
plasmon
resonance
indicated
possessed
higher
affinity
for
than
other
promoters,
such
DMP-1,
OPN,
BSP
DSPP.
These
features
contribute
blocking
intrafibrillar
fibrils
during
polymer-induced
liquid-precursor
process
when
are
cross-linked
with
DCN.
This
effect
more
remarkable
were
phosphorylated
sodium
trimetaphosphate,
shown
observation
tube-like
morphology
via
TEM
mineral
sheath
SEM.
study
enhances
understanding
role
regulation
among
tissues.
provides
insights
development
biomaterials
interfaces
soft
hard
Interdisciplinary materials,
Journal Year:
2024,
Volume and Issue:
3(5), P. 738 - 756
Published: June 2, 2024
Abstract
Due
to
tissue
lineage
variances
and
the
anisotropic
physiological
characteristics,
regenerating
complex
osteochondral
tissues
(cartilage
subchondral
bone)
remains
a
great
challenge,
which
is
primarily
due
distinct
requirements
for
cartilage
bone
regeneration.
For
regeneration,
significant
amount
of
newly
generated
chondrocytes
required
while
maintaining
their
phenotype.
Conversely,
regeneration
necessitates
inducing
stem
cells
differentiate
into
osteoblasts.
Additionally,
construction
interface
crucial.
In
this
study,
we
fabricated
biphasic
multicellular
bioprinted
scaffold
mimicking
natural
employing
three‐dimensional
(3D)
bioprinting
technology.
Briefly,
gelatin‐methacryloyl
(GelMA)
loaded
with
articular
marrow
mesenchymal
(ACs/BMSCs),
serving
as
layer,
preserved
phenotype
ACs
promoted
differentiation
BMSCs
through
interaction
between
BMSCs,
thereby
facilitating
GelMA/strontium‐substituted
xonotlite
(Sr‐CSH)
regulated
osteoblasts
enhanced
secretion
matrix
by
in
layer
slow
release
bioactive
ions
from
Sr‐CSH.
GelMA,
material,
contributed
reconstruction
interface.
Ultimately,
demonstrated
satisfactory
simultaneous
defects.
promising
strategy
application
3D
technology
was
proposed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: April 9, 2024
Abstract
Injectable
hydrogels
have
emerged
as
versatile
materials
with
potential
applications
in
various
fields,
including
biomedicine,
lubrication,
adhesion,
surface
coatings,
and
tissue
engineering.
However,
the
critical
aspect
of
spreading
wetting
on
substrates,
which
is
essential
for
obtaining
significant
interfacial
properties,
has
not
been
adequately
addressed.
This
work
presents
an
approach
to
prepare
hydrogel
coatings
kinds
substrates
through
superspreading
polyelectrolyte
complex
solution
during
its
liquid‐liquid
phase
inversion
process.
Due
low
tension,
spreads
wets
surfaces
underwater
driven
by
osmotic
pressure,
improving
contact
area
interface
integration.
Combined
simultaneous
sol‐gel
transition
electrostatic
interaction,
it
forms
a
stable
homogeneous
coating.
The
coating
possesses
control
thickness
(4–8
µm),
improved
hydrophilicity
(CA
decrease
from
102°
10°),
toughness
(increase
70
455
J
m
−2
),
lubrication
performance
(coefficients
friction
0.712
0.112).
provides
excellent
opportunity
investigate
spreadability
wettability
water/water/solid
three‐phase
system
develop
functional
applications.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(16), P. 10840 - 10849
Published: April 15, 2024
External
electric
field
has
the
potential
to
influence
metabolic
processes
such
as
biological
hydrogen
production
in
microorganisms.
Based
on
this
concept,
we
designed
and
constructed
an
electroactive
hybrid
system
for
microbial
biohydrogen
under
comprised
of
polydopamine
(PDA)-modified
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Mineralized
collagen
fibrils
are
the
building
blocks
of
bone,
and
mineralization
is
generally
regulated
by
noncollagenous
proteins
(NCPs).
However,
functions
NCPs
difficult
to
investigate
in
vivo.
Here,
we
use
poly(acrylic
acid)
(PAA)
with
different
molecular
weights
(5,
50,
450,
4000
kDa)
as
analogs
explore
their
effects
on
vitro.
All
PAA
molecules
can
promote
intrafibrillar
calcium
carbonate
(CaCO3)
following
these
steps:
precursors
infiltrate
gap
zones
collagen,
transform
into
organized
calcite
nanocrystals
within
collagen.
An
increase
weight
significantly
accelerates
rate
films,
approximately
0.67
μm
min–1
at
kDa,
four
times
that
5
kDa
(0.16
min–1).
generation
contractile
stress
via
tendons
exhibits
a
contrary
tendency.
It
reaches
24.2
MPa
much
higher
than
(8.3
MPa),
due
rapid
causing
severe
extrafibrillar
precipitation
around
tendon.
The
controllable
matrices
may
inspire
development
bone
repair
regeneration
future.
