Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS) DOI Open Access
Livia Beccacece, Filippo Costa, Jennifer P. Pascali

et al.

Published: June 28, 2023

In the recent decades, per- and polyfluoroalkyl substances (PFAS) have garnered widespread public attention due to their persistence in environment detrimental effects on health of living organisms, spurring generation several transcriptome-centered investigations understand biological basis mechanism. this study, we collected 2144 publicly available samples from 7 distinct animal species examine molecular responses PFAS exposure determine if there are conserved responses. Our comparative transcriptional analysis revealed that is across different tissues, molecules species. We identified reported genes exhibiting consistent evolutionarily response PFAS, such as ESR1, HADHA ID1, well pathways including lipid metabolism, immune hormone pathways. This study provides first evidence induce comparable changes affect same metabolic processes inter-species borders. findings significant implications for understanding impact organisms environment. believe offers a novel perspective foundation future research into developing strategies mitigating these ecosystem.

Language: Английский

Interactions between Per- and Polyfluoroalkyl Substances (PFAS) at the Water–Air Interface DOI
Amélie C. Lemay, Ian C. Bourg

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Per- and polyfluoroalkyl substances (PFAS)─so-called "forever chemicals"─contaminate the drinking water of about 100 million people in U.S. alone are inefficiently removed by standard treatment techniques. A key property these compounds that underlies their fate transport efficacy several promising remediation approaches is they accumulate at water–air interface. This phenomenon remains incompletely understood, particularly under conditions relevant to natural systems where interfaces often carry significant loads other organic contaminants or matter. To understand impact loading on PFAS adsorption, we carried out molecular dynamics simulations varying interfacial densities. We find adsorbed form strong mutual interactions (attraction between perfluoroalkyl chains electrostatic among charged head groups) give rise ordered coatings. These involve near-cancellation hydrophobic attraction Coulomb repulsion. Our findings explain an apparent paradox whereby adsorption isotherms suggest minimal while simultaneously displaying a high sensitivity composition density Consideration present with interface has potential allow for more accurate predictions design efficient approaches.

Language: Английский

Citations

2
Suspect, Nontarget Screening, and Toxicity Prediction of Per- and Polyfluoroalkyl Substances in the Landfill Leachate DOI
Chao Feng, Yuanjie Lin,

Sunyang Le

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(10), P. 4737 - 4750

Published: Feb. 26, 2024

Landfills are the final stage of urban wastes containing perfluoroalkyl and polyfluoroalkyl substances (PFASs). PFASs in landfill leachate may contaminate surrounding groundwater. As major environmental pollutants, emerging have raised global concern. Besides widely reported legacy PFASs, distribution potential toxic effects numerous remain unclear, unknown still need discovery characterization. This study proposed a comprehensive method for PFAS screening samples using suspect nontarget analysis. A total 48 from 10 classes were identified; nine novel including eight chloroperfluoropolyether carboxylates (Cl-PFPECAs) bistriflimide (HNTf2) first time leachate, where Cl-PFPECA-3,1 Cl-PFPECA-2,2 media. Optimized molecular docking models established prioritizing with activity against peroxisome proliferator-activated receptor α estrogen α. Our results indicated that several

Language: Английский

Citations

11
Sustainable Management of Poly- and Perfluoroalkyl Substances (PFASs)-Contaminated Areas: Tackling a Wicked Environmental Problem DOI Open Access
Giancarlo Renella, Paolo Carletti, Antonio Masi

et al.

Sustainability, Journal Year: 2025, Volume and Issue: 17(2), P. 510 - 510

Published: Jan. 10, 2025

This study evaluates the reasons and factors making soil pollution by poly- perfluoroalkyl substances (PFASs) a wicked problem, reflecting upon nature, persistence, mobility, bioaccumulative properties of these compounds. The current regulation trends in production use such are also explored. highlights conflict between need for phasing out PFASs their indispensable role many strategic applications. We summarize knowledge on complex chemical to highly variable soils, mechanisms partitioning transport soil, exposure pathways humans. In particular, we focus that lead PFAS accumulation edible parts cultivated plants present some potential sustainable management practices could result risk mitigation environmental remediation actions. stemming from merging theoretical considerations pragmatic approaches mitigating problems related agricultural soils. highlight importance co-creation processes adoption solutions vast polluted areas make impacted populations discouraged, like being front an ‘untameable beast’, leading protests irrational behavior. our opinion, this might engage population more optimistic strategies tackle soliciting authorities stakeholders implement beyond actual practice supporting new policy development.

Language: Английский

Citations

1
Invited Perspective: Reference Standards Are Key to Environmental and Human Health Research—The Case of PFAS DOI Creative Commons
Kurunthachalam Kannan

Environmental Health Perspectives, Journal Year: 2025, Volume and Issue: 133(1)

Published: Jan. 1, 2025

Language: Английский

Citations

1
Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids DOI Creative Commons
Gregory C. Addicks,

Andrea Rowan‐Carroll,

Anthony Reardon

et al.

Toxicological Sciences, Journal Year: 2023, Volume and Issue: 194(1), P. 38 - 52

Published: May 17, 2023

Per- and polyfluoroalkyl substances (PFAS) are a wide range of chemicals that used in variety consumer industrial products leading to direct human exposure. Many PFAS chemically nonreactive persistent the environment, resulting additional exposure from water, soil, dietary intake. While some have documented negative health effects, data on simultaneous exposures multiple (PFAS mixtures) inadequate for making informed decisions risk assessment. The current study leverages previous work our group using Templated Oligo-Sequencing (TempO-Seq) high-throughput transcriptomic analysis PFAS-exposed primary liver cell spheroids; herein, we determine potency mixtures. Gene expression single mixture spheroids were subject benchmark concentration (BMC) analysis. We 25th lowest gene BMC as point departure compare potencies mixtures varying complexity composition. Specifically, empirical 8 compared predicted calculated principal addition (ie, dose addition) which component summed by proportion predict potency. In this study, most mixtures, comparable through addition. This supports effects largely follow response suggests these individual not strongly synergistic or antagonistic.

Language: Английский

Citations

22
A New CSRML Structure-Based Fingerprint Method for Profiling and Categorizing Per- and Polyfluoroalkyl Substances (PFAS) DOI Creative Commons
Ann M. Richard,

Ryan Lougee,

Matthew S. Adams

et al.

Chemical Research in Toxicology, Journal Year: 2023, Volume and Issue: 36(3), P. 508 - 534

Published: March 2, 2023

The term PFAS encompasses diverse per- and polyfluorinated alkyl (and increasingly aromatic) chemicals spanning industrial processes, commercial uses, environmental occurrence, potential concerns. With increased chemical curation, currently exceeding 14,000 structures in the PFASSTRUCTV5 inventory on EPA's CompTox Chemicals Dashboard, has come motivation to profile, categorize, analyze structure space using modern cheminformatics approaches. Making use of publicly available ToxPrint chemotypes ChemoTyper application, we have developed a new PFAS-specific fingerprint set consisting 129 TxP_PFAS coded CSRML, chemical-based XML-query language. These are split into two groups, first containing 56 mostly bond-type ToxPrints modified incorporate attachment either CF group or F atom enforce proximity fluorinated portion chemical. This focus resulted dramatic reduction chemotype counts relative corresponding (averaging 54%). remaining consist various lengths types chains, rings, bonding patterns covering indications branching, alternate halogenation, fluorotelomers. Both groups well represented across PFASSTRUCT inventory. Using show how can be visualized, filtered, used profile inventory, as construct chemically intuitive, structure-based categories. Lastly, selection expert-based categories from OECD Global list evaluate small analogous were able recapitulate category concepts based clearly defined rules that computationally implemented reproducibly applied process large inventories without need consult an expert. support computational modeling, harmonize categories, facilitate communication, allow for more efficient informed exploration moving forward.

Language: Английский

Citations

17
Complete defluorination of per- and polyfluoroalkyl substances — dream or reality? DOI Creative Commons
Jan-Max Arana Juve, Bo Wang, Michael S. Wong

et al.

Current Opinion in Chemical Engineering, Journal Year: 2023, Volume and Issue: 41, P. 100943 - 100943

Published: July 17, 2023

The consensus of removing per- and polyfluoroalkyl substances (PFAS) from the environment is widely recognized enlightened by near-zero standards released U.S. Environmental Protection Agency in 2023. only way to achieve goal zero fluoro-pollution fully defluorinate or mineralize PFAS, but current technologies partially a limited number which can lead creation potentially more toxic short-chain intermediates. Therefore, we discuss herein need broaden scope tested summarize state-of-the-art degradation technologies, provide perspectives complete defluorination. Besides fundamental knowledge gaps defluorination reactions, technological aspects water matrix effects, pilot tests, cost analysis also limit application comparison different treatment technologies. This work would shed light on further research find solutions PFAS.

Language: Английский

Citations

17
Fluorobenzene as new working fluid for high-temperature heat pumps and organic Rankine cycles: Energy analysis and thermal stability test DOI Creative Commons
Michele Doninelli, Gioele Di Marcoberardino, Ivano Alessandri

et al.

Energy Conversion and Management, Journal Year: 2024, Volume and Issue: 321, P. 119023 - 119023

Published: Sept. 16, 2024

Language: Английский

Citations

7
Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots DOI Creative Commons
Jeremy P. Koelmel,

Elizabeth Z. Lin,

Emily Parry

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 883, P. 163579 - 163579

Published: April 24, 2023

Language: Английский

Citations

15
Life in the PFAS lane: The impact of perfluoroalkyl substances on photosynthesis, cellular exudates, nutrient cycling, and composition of a marine microbial community DOI
S. Davis,

Shaley M. Klumker,

Alexis A. Mitchell

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 171977 - 171977

Published: March 27, 2024

Language: Английский

Citations

4