Evidence linking cadmium and/or lead exposure to immunomodulatory effects in mammals based upon an adverse outcome pathways approach, and research perspectives

Chemosphere, Journal Year: 2025, Volume and Issue: 371, P. 144056 - 144056

Published: Jan. 4, 2025

For decades, studies have shown how exposure to non-essential trace metals such as lead (Pb) and cadmium (Cd) largely impact global wildlife. Ecoimmunotoxicology has emerged in the past two decades focuses on effects of pollutants immune system free-ranging organisms. Adverse outcome pathways (AOPs) represent a conceptual approach explore mechanistic linkage between molecular initiating event adverse outcomes, potentially at all biological levels organisation. The present paper proposes putative AOPs related Cd, Pb, mixture Cd-Pb, mammals address future questions ecoimmunotoxicology. Molecular Initiating Events for both relate entrance cells through Ca2+ channels or bond cell surfaces. Exposure Pb Cd-Pb share several similar Key (KEs), primarily an increase oxidative stress (OS) production reactive oxygen species. mixture, OS affects mitochondrial membranes, induces apoptosis, ultimately decreasing number. Both affect innate nuclear factor kappa B (NF-κB) mitogen-activated protein kinase (MAPK) inflammatory signalling pathways, leading upregulation markers mediators. Adaptive is also affected by though decrease CD4+/CD8+ ratio, MHCII, inactivation TH1 TH2 response, inhibition humoral response mediated various Ig. Mixture are less documented resulting more speculative AOP, but potential synergic antagonistic were identified. According our AOPs, further research ecoimmunotoxicology should focus KEs NF-κB/MAPK changes ratio MHCII complexes, AOs auto-immune disorders effective infection rate, particularly case metal mixtures.

Language: Английский

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Main conclusions and perspectives from the collective scientific assessment of the effects of plant protection products on biodiversity and ecosystem services along the land–sea continuum in France and French overseas territories

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 32(6), P. 2757 - 2772

Published: April 26, 2023

Language: Английский

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Wildlife ecotoxicology of plant protection products: knowns and unknowns about the impacts of currently used pesticides on terrestrial vertebrate biodiversity

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

Language: Английский

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Landscapes of risk: A comparative analysis of landscape metrics for the ecotoxicological assessment of pesticide risk to bees

Journal of Applied Ecology, Journal Year: 2024, Volume and Issue: 61(5), P. 975 - 986

Published: March 13, 2024

Abstract Pesticide use in agricultural landscapes creates environmental contamination that is heterogenous space and time. Mobile organisms, such as bees, are exposed to multiple sources when visiting patches vary the amount, timing toxicity of pesticides used. Yet, risk assessments (ERA) typically fail consider this heterogeneity, part because complexities estimating exposure different pesticides, subsequent at organism‐relevant scales. We pesticide assays 269 bee‐collected pollen samples understand spatiotemporal variability across a network 41 field sites southern Sweden. Observed bee calculated based on compound‐specific residue quantifications standardized data. then compare ability three classes landscape‐scale variables predict risk: (1) landscape composition configuration metrics, (2) load national data (3) predictions from newly developed model. Based data, 10 crops account for 81% total risk. detected 49 compounds pollen. Although herbicides fungicides constitute bulk both frequency amount quantified, unsurprisingly, insecticides contribute most Landscape metrics did not observed risk, interactions with species indicate taxa‐dependency predictions. predicted consistently between taxa. Risk estimates our model were strongly predictive but only considering realized (i.e., prior information). Synthesis applications . Predicting patterns could enable ERA. However, simple pattern, proportion land, sufficient. found was best integrating spatialized model, underscoring importance research, monitoring mitigation. Further, we propose guidance framework future ecotoxicological analyses clarifies needs relative prediction goals.

Language: Английский

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Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”?

Peer Community Journal, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 23, 2025

Language: Английский

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Assessing Bioaccumulation with Biomagnification Factors (BMF) from Dietary Bioaccumulation Tests

Integrated Environmental Assessment and Management, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Despite the fact that UN Stockholm Convention on persistent organic pollutants specifically acknowledges Arctic ecosystems and Indigenous communities are particularly at risk due to biomagnification of contaminants in traditional foods, bioconcentration factor (BCF) substances fish remains preferred metric for identifying potential substances. The BCF measures uptake from water water-breathing organisms, but not food sources. purpose this study is investigate how (BMF) can be used bioaccumulation assessments. To address question, data dietary aqueous studies were compiled a wide range (i) correlation between BMF same substance species (ii) computational methods deriving both results empirical tests. analysis concludes correlations limited use assessment; test screening; supports assessing organisms.

Language: Английский

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Diet and methyl mercury contamination of nestling red-winged blackbirds

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: 44(1), P. 59 - 67

Published: Jan. 1, 2025

Abstract Methyl mercury (MeHg) is a widespread environmental contaminant that can have adverse effects on the health of vertebrate wildlife. This study focused diets and MeHg contamination nestling red-winged blackbirds (Agelaius phoeniceus) from wetland in north Texas, USA. In previous research at site, risk assessment model suggested if emergent aquatic insects (i.e., odonates) were dominant prey item diets, could be negatively affected. The purpose this was to follow up an earlier determine whether accumulating elevated concentrations our site. We had four objectives: (1) estimate proportion insects, spiders, terrestrial using stable isotope-based dietary mixing model; (2) assess insects; (3) blood blackbirds; (4) high enough pose risk. found diet dominated by insect with low nestlings their blood, well below hazardous levels. results suggest caution must used when interpreting models for blackbirds. Because consist varying proportions assessments based estimates literature Hg should followed studies and/or actual level nestlings.

Language: Английский

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Heavy metal concentrations in feathers and metabolomic profiles in Pacific black ducks (Anas superciliosa) from Southeastern Australia

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: 44(1), P. 92 - 102

Published: Jan. 1, 2025

Heavy metals are cumulative toxicants that frequently create negative health effects for waterbirds inhibiting contaminated freshwater systems. Although levels of exposure to heavy have been well documented many waterbird species, the adverse remain relatively poorly understood. One emerging field allows exploration such is metabolomics. The aim this study was characterize metabolomic profiles in relation long-term metal a species. In 2021, wings from 44 Pacific black ducks (Anas superciliosa) were collected by recreational hunters at three sites Victoria, southeastern Australia. concentrations seven measured feathers and these data quantified via inductive coupled plasma mass spectrometry compared with semiquantitative assessment 21 metabolites identified muscle tissues same birds gas chromatography-mass spectrometry. Principal component analysis conducted test associations between metabolites, metals, sites. Mean detected copper (9.97 µg/g), chromium (0.73 iron (123.24 manganese (13.01 mercury (0.58 lead (0.86 zinc (183.95 µg/g; dry wt). No association found 17 whereas four negatively associated some metals: α-linolenic acid iron, glucose manganese, lactic mercury, propanoic mercury. There few differences studied This provides novel approach combining toxicological an ecologically important species global region.

Language: Английский

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Environmental contaminants assessment for frequently harvested migratory waterfowl in the Northeast Atlantic flyway

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 963, P. 178474 - 178474

Published: Jan. 15, 2025

Language: Английский

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Minor and trace element concentrations in roe deer hair: A non-invasive method to define reference values in wildlife

Ecological Indicators, Journal Year: 2024, Volume and Issue: 159, P. 111720 - 111720

Published: Feb. 1, 2024

Most chemical elements are crucial for life maintenance, but the intake of non-essential or inadequate concentrations essential ones can have major consequences on wildlife health. However, minor and trace remain largely unknown in free-ranging animals. This study aimed to establish first reference values 22 (Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, Se, Zn) (Al, As, Cd, Hg, Pb, Sb, Sr, Ti, Tl) roe deer hair (Capreolus capreolus), assess degree covariation between elements, investigate how individual characteristics environmental context influence element profiles. To do so, 758 samples from 542 individuals were collected 2016 2019 five populations (i.e. Ain, Chizé, Châteauvillain-Arc-en-Barrois, Jura Trois-Fontaines) inhabiting contrasted habitats France. Compared scarce literature hair, generally lower, correlations mostly positive. Element also heterogeneously distributed among populations, with overall greater heterogeneity two Châteauvillain-Arc-en-Barrois) which could be explained by their specific (e.g. vegetation, climate, altitude). Overall, did not differ according age sex. Further studies bioavailability needed clarify whether observed is primarily driven geographical characteristics.

Language: Английский

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