Association between preoperative systemic immune inflammation index and postoperative sepsis in patients with intestinal obstruction: A retrospective observational cohort study

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(2)

Published: Feb. 1, 2024

Sepsis is a severe complication that results in increased morbidity and mortality after intestinal obstruction surgery. This study examined the role of preoperative systemic immune inflammation index (SII) for postoperative sepsis patients.

Language: Английский

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Preoperative SII Can Predict Postoperative Recurrence and Serious Complications in Patients with Hepatolithiasis

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3321 - 3331

Published: March 1, 2025

Purpose: The occurrence and progression of hepatolithiasis are related to inflammatory reactions immune proteins. This study aims evaluate the relationship between systemic index (SII) in recurrence-free survival (RFS), as well incidence severe postoperative complications patients. Patients Methods: We retrospectively analyzed 177 patients with hepatolithiasis. optimal cut-off values SII, response (SIRI), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) prognostic nutritional (PNI) were evaluated by analysis receiver operating characteristic (ROC) curve. SIRI, NLR clinical results was tested χ ²-test. Logical regression is used risk factors serious complications. Kaplan-Meier curve Cox analyses impact on RFS. Results: ROC determines value area under (AUC) NLR, MLR, PLR PNI, then grouped. In multivariate analysis, surgical method (HR=3.331, 95% CI: 1.360– 8.158, p=0.008) SII (HR=2.883, 1.084– 7.668, p=0.034) identified independent for complications; cox demonstrated that a history gallstones (HR=1.965, 1.206– 3.201, p=0.007), (HR=2.818, 1.340– 5.926, p=0.006), MLR (HR=3.240, 1.158– 9.067, p=0.025) RFS; show low levels (p< 0.001), SIRI (p=0.005), 0.001) had significantly higher RFS compared those high-level group. Conclusion: Preoperative high associated recurrence hepatolithiasis, an factor both Keywords: index, survival, complications, predict

Language: Английский

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Impact of preoperative inflammatory biomarkers on postoperative pneumonia and one-month pulmonary imaging changes after surgery for non-small cell lung cancer

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 18, 2025

This study examined the effectiveness of preoperative inflammatory markers in predicting occurrence postoperative pneumonia (POP) and clinical outcomes based on chest computed tomography (CT) images patients who underwent surgical resection for non-small cell lung cancer (NSCLC). retrospective included NSCLC surgery at The First People's Hospital Jiande between January 2019 October 2023. Data demographic characteristics, biomarkers, approach duration, outcomes, CT findings 1 month postoperatively were collected analyzed. POP after was assessed using propensity score matching. Among 568 patients, 72 (12.7%) had POP. After matching, 252 (POP group: 66; non-POP 186) analysis. systemic immune-inflammation index (SII) platelet-to-lymphocyte ratio (PLR) significantly higher group than (433.53 vs. 323.75, P = 0.001; 126.42 103.64, < 0.001). length hospital stay percentage improved clinically (11 days 9 days, 0.008; 77.3% 59.7%, 0.033). Multivariate analysis showed that PLR lymphocyte-to-monocyte (LMR) independent predictors (AUC 0.780 0.730, both However, there no significant differences radiographic among stratified by risk LMR accurately predict with NSCLC. Nonetheless, these ratios may not resection.

Language: Английский

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Association between hematological inflammatory markers and latent TB infection: insights from NHANES 2011–2012 and transcriptomic data

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 19, 2025

Background Latent tuberculosis infection affects about one-quarter of the global population and can progress to active tuberculosis. Hematological inflammatory markers, such as systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte monocyte-to-lymphocyte reflect inflammation immune status but are understudied in latent infection. This study investigates association between these markers a nationally representative sample. Methods Data from 7,042 participants 2011–2012 National Health Nutrition Examination Survey transcriptomic data GSE19491 dataset were analyzed. was identified using QuantiFERON-TB Gold assay. parameters measured via complete blood counts, calculated through parameters. Statistical analyses included linear regression adjusted for confounders subgroup analyses. Transcriptomic involved cell profiling, gene set enrichment, checkpoint expression. Results Individuals with had significantly lower ratio. These associations remained significant after adjusting age, gender, body mass diabetes, hypertension. revealed heightened activation memory CD4 CD8 T cells, increased cytolytic activity, upregulated T-cell co-inhibition pathways, alongside differential expression genes individuals Conclusions A index other related hematological independently correlate findings underscore potential significance identifying understanding Further exploration may enhance diagnostic therapeutic strategies

Language: Английский

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