The impact of novel probiotics isolated from the human gut on the gut microbiota and health DOI
Robert Caesar

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract The gut microbiota plays a pivotal role in influencing the metabolism and immune responses of body. A balanced microbial composition promotes metabolic health through various mechanisms, including production beneficial metabolites, which help regulate inflammation support functions. In contrast, imbalance microbiota, known as dysbiosis, can disrupt processes increase risk developing diseases, such obesity, type 2 diabetes, inflammatory disorders. is dynamic be influenced by environmental factors diet, medication, consumption live bacteria. Since early 1900s, bacteria isolated from food have been used probiotics. However, human also offers an enormous reservoir bacterial strains, recent advances research led to discovery strains with probiotic potentials. These derived broad spectrum taxa, differ their ecological properties how they interact hosts. For most probiotics structural components short‐chain fatty acids, contribute maintenance immunological homeostasis regulating reinforcing barrier integrity. Metabolites produced for cross‐feeding promote microbiota. Despite challenges related safety, stability, strain‐specific properties, several newly identified offer great potential personalized interventions, allowing targeted strategies.

Language: Английский

Gut microbiota and atrial cardiomyopathy DOI Creative Commons

Tingting Sun,

Beibei Song, Bo Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Language: Английский

Citations

0
Helicobacter pylori infection process: from the molecular world to clinical treatment DOI Creative Commons
MinKyung Yi,

S. Chen,

Xiaoping Yi

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

Helicobacter pylori is a gram-negative microaerophilic microorganism intricately associated with chronic gastrointestinal disorders and gastric cancer. H. can cause various upper digestive tract diseases, including gastritis, peptic ulcer, gastroesophageal reflux disease, The bacterium exhibits variety of pathogenic mechanisms, colonization, the expression virulence factors, development drug resistance. This article presents comprehensive review pathogenesis, emphasizing recent research advancements concerning cytotoxin-associated gene A, vacuolating cytotoxin, outer membrane proteins, other factors. Additionally, it examines molecular mechanisms underlying resistance evaluates efficacy conventional therapeutic approaches. Recently, researchers have attempted novel regimens, probiotics Chinese medicine-assisted therapies, to enhance effects. aimed offer an overview academic community's comprehension infection highlight current treatment options.

Language: Английский

Citations

0
Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria DOI Creative Commons
Wenwen Ding, Yiwen Cheng, Xia Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Antimicrobial resistance (AMR) has become a major and escalating global health threat, undermining the effectiveness of current antibiotic antimicrobial therapies. The rise multidrug-resistant bacteria led to increasingly difficult-to-treat infections, resulting in higher morbidity, mortality, healthcare costs. Tackling this crisis requires development novel agents, optimization therapeutic strategies, initiatives infection surveillance control. Recent studies highlight crucial role human gut microbiota defending against AMR pathogens. A balanced protects body through mechanisms such as colonization resistance, positioning it key ally fight AMR. In contrast, dysbiosis disrupts defense, thereby facilitating persistence, colonization, dissemination resistant This review will explore how influence drug-resistant bacterial its involvement various types AMR-related potential for microbiota-targeted therapies, fecal transplantation, prebiotics, probiotics, phage therapy. Elucidating interactions between pathogens provide critical insights developing strategies prevent treat infections. While previous reviews have focused on general impact health, specifically look at latest research evolution spread AMR, highlighting strategies.

Language: Английский

Citations

0
Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead DOI
Peng Xue, Chao Luo,

J Li

et al.

International Journal of Drug Discovery and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 100007 - 100007

Published: April 9, 2025

Review Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead Peng Xue 1,†, Chao Luo 2,†, Jiashu Li 3, Liang Yang 3,* Yuanyuan Ma 1,* 1 Nantong Key Laboratory of Environmental Toxicology, Department Occupational Medicine School Public Health, University, 226019, China 2 The People’s Hospital Rugao, Affiliated Rugao Xinglin College, 226500, 3 Medicine, Southern University Science Technology, Shenzhen 518055, * Correspondence: [email protected] (L.Y.); [email protected] (Y.M.) Received: 15 September 2024; Revised: 23 October Accepted: Published: 9 April 2025 Abstract: in human gut microbiota participate maintenance health regulation physiological processes. This review examines complex role fungi, highlighting challenges such as diverse fungal populations, cultivation difficulties, knowledge gaps their functional roles. Recent advancements metagenomics metabolomics have enabled innovative investigations into communities, revealing influence on host metabolism immune responses. Future research should address existing explore therapeutic applications fungi. Interdisciplinary collaborations new methodologies are proposed to enhance current understanding fungi-host interactions, ultimately improving outcomes guide development novel treatment strategies. emphasizes need integrate microbiome studies provide a comprehensive health.

Language: Английский

Citations

0
Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases DOI Open Access
Natalia Kurhaluk, Piotr Kamiński, Rafał Bilski

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3658 - 3658

Published: April 12, 2025

This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.

Language: Английский

Citations

0
Gut microbiome and inflammation in cardiovascular drug response: trends in therapeutic success and commercial focus DOI
Firoz Anwar, Fahad A. Al‐Abbasi,

Omar A. Al-Bar

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

Citations

1
Modulação da Microbiota Intestinal como Estratégia Terapêutica no Tratamento do Melanoma DOI Creative Commons
Tuany Caroline Bernardi,

Vanessa Mazzardo,

Isabele Dallacort

et al.

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2024, Volume and Issue: 6(8), P. 2875 - 2883

Published: Aug. 19, 2024

A microbiota intestinal, uma comunidade complexa de microrganismos, tem emergido como modulador crucial na homeostase do hospedeiro e resposta a doenças o melanoma, um câncer pele altamente agressivo. Este artigo revisa os mecanismos pelos quais influencia desenvolvimento, progressão terapêutica melanoma. interação entre sistema imunológico é analisada, mostrando microrganismos comensais modulam imune inata adaptativa por meio da com células dendríticas, macrófagos, linfócitos T, produção citocinas quimiocinas. Também se discute impacto metabólitos microbianos, ácidos graxos cadeia curta, biliares secundários compostos fenólicos derivados dieta, sinalização celular modulação microambiente tumoral. Estrategias emergentes, uso probióticos, prebióticos, antibióticos seletivos, transplante fecal intervenções dietéticas, são avaliadas pelo seu potencial em otimizar mitigar efeitos adversos. integração abordagens baseadas microbiana pode transformar tratamento melhorando eficácia qualidade vida dos pacientes. Futuras pesquisas devem focar personalização dessas intervenções, considerando composição individual pacientes subjacentes essas interações.

Citations

0
Novel Substituted Benzimidazole Compounds as TLR9 Inhibitors for Treating Fibrotic Diseases, Particularly Idiopathic Pulmonary Fibrosis DOI Creative Commons
Ram W. Sabnis

ACS Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(11), P. 1804 - 1805

Published: Oct. 16, 2024

Provided herein are novel substituted benzimidazole compounds as TLR9 inhibitors, pharmaceutical compositions, use of such in treating fibrotic diseases, particularly idiopathic pulmonary fibrosis, and processes for preparing compounds.

Language: Английский

Citations

0
The impact of novel probiotics isolated from the human gut on the gut microbiota and health DOI
Robert Caesar

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract The gut microbiota plays a pivotal role in influencing the metabolism and immune responses of body. A balanced microbial composition promotes metabolic health through various mechanisms, including production beneficial metabolites, which help regulate inflammation support functions. In contrast, imbalance microbiota, known as dysbiosis, can disrupt processes increase risk developing diseases, such obesity, type 2 diabetes, inflammatory disorders. is dynamic be influenced by environmental factors diet, medication, consumption live bacteria. Since early 1900s, bacteria isolated from food have been used probiotics. However, human also offers an enormous reservoir bacterial strains, recent advances research led to discovery strains with probiotic potentials. These derived broad spectrum taxa, differ their ecological properties how they interact hosts. For most probiotics structural components short‐chain fatty acids, contribute maintenance immunological homeostasis regulating reinforcing barrier integrity. Metabolites produced for cross‐feeding promote microbiota. Despite challenges related safety, stability, strain‐specific properties, several newly identified offer great potential personalized interventions, allowing targeted strategies.

Language: Английский

Citations

0