Renal implications of systemic lupus erythematosus pathogenesis and treatment

International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that significantly contributes to morbidity and mortality. Its pathogenesis involves complex interactions between immune dysregulation, genetic susceptibility, environmental factors, resulting in deposition subsequent renal inflammation. Advances understanding these mechanisms have highlighted the role B cells, cytokines, complement system disease progression. Current therapeutic strategies rely on immunosuppressants such as glucocorticoids, cyclophosphamide, mycophenolate mofetil, which proven effective managing inflammation but carry risks significant adverse effects. Biologic agents targeting cells components, including belimumab eculizumab, demonstrated promise improving outcomes reducing activity refractory cases. The discovery novel biomarkers transforming diagnosis management LN. Urinary markers like MCP-1 activation products offer non-invasive tools for monitoring predicting relapses. Molecular studies identified microRNAs variants potential indicators susceptibility response. metabolomics proteomics revealed metabolic protein profiles unique LN, offering insights into new targets intervention. Emerging technologies artificial intelligence are revolutionizing analysis biomarker data, enabling personalized treatment approaches. These advances highlight importance integrating multidisciplinary research efforts optimize patient care. While challenges remain, heterogeneity LN disparities access care, ongoing paving way improved options outcomes. Precision medicine, driven by innovative therapies, holds transform landscape management, hope better preservation quality life affected individuals.

Language: Английский

Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

IFI27, an interferon (IFN)-stimulated gene, is emerging as a crucial player in immune responses across various species, with significant implications for precision medicine. Commonly found among the most upregulated genes infections, cancers, well inflammatory and autoimmune disorders, IFI27 ready to be trialed clinical practice certain indications, holds promise immunomodulatory target. We hypothesize that plays dual role, typically supporting defense but sometimes contributing disease progression, which might render it putative biomarker diagnosis, prognosis, treatment response. advocate focused research on unlock its potential medicine contribute unifying framework of mechanisms Our viewpoint supported by numerous studies highlighting IFI27's involvement conditions possibilities application.

Language: Английский