Possible role of LCZ696 in atherosclerosis: new inroads and perspective

Molecular and Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 479(8), P. 1895 - 1908

Published: Aug. 1, 2023

Language: Английский

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Impact of Cardiac and Cerebrovascular Complications During Hospitalization on Long-Term Prognosis in Patients With COVID-19

The American Journal of Cardiology, Journal Year: 2023, Volume and Issue: 209, P. 114 - 119

Published: Oct. 12, 2023

Language: Английский

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Genetic and immunological insights into COVID-19 with acute myocardial infarction: integrated analysis of mendelian randomization, transcriptomics, and clinical samples

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 6, 2023

Background Globally, most deaths result from cardiovascular diseases, particularly ischemic heart disease. COVID-19 affects the heart, worsening existing conditions and causing myocardial injury. The mechanistic link between acute infarction (AMI) is still being investigated to elucidate underlying molecular perspectives. Methods Genetic risk assessment was conducted using two-sample Mendelian randomization (TSMR) determine causality AMI. Weighted gene co-expression network analysis (WGCNA) machine learning were used discover validate shared hub genes for two diseases bulk RNA sequencing (RNA-seq) datasets. Additionally, set enrichment (GSEA) single-cell RNA-seq (scRNA-seq) analyses performed characterize immune cell infiltration, communication, correlation of genes. To findings, expression patterns confirmed in clinical blood samples collected patients with Results TSMR did not find evidence supporting a causal association or severe In discovery cohorts both AMI, WGCNA’s intersection identified TLR4 ABCA1 as significant genes, demonstrating high diagnostic predictive value validation cohort. Single-gene GSEA single-sample (ssGSEA) revealed inflammatory roles ABCA1, linked various infiltrations. Furthermore, scRNA-seq unveiled dysregulation patients, characterized by altered proportions, phenotypic shifts, enhanced cell-cell elevated CD16 monocytes. Lastly, increased TLR4, but validated Conclusion No genetic AMI dysregulated may be responsible development responses

Language: Английский

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Electrolytes, Zinc and Vitamin D₃ in COVID-19 Patients with Cardiovascular Complications

Problems of Virology, Journal Year: 2024, Volume and Issue: 69(3), P. 266 - 276

Published: July 5, 2024

Introduction. COVID-19 is strongly linked to cardiovascular disease, with direct myocardial injury and systemic inflammation as common mechanisms. Pre-existing or infection-induced disease worsens the outcomes for patients. Materials methods. To estimate serum electrolytes (Na+, K+, Ca++, Zn) vitamin D3, study depended on ichroma ii device Vitamin D3 Chemistry Analyzer in patient samples. Results. A was conducted 192 individuals diagnosed COVID-19, including 35 critical cases, 53 severe 54 moderate 50 a control group. The age group highest prevalence of infection between 50‒69 years, while lowest observed those under 30 years. found significant decreases calcium, potassium, sodium, zinc, levels among patients compared Zinc showed correlation sex, males experiencing decline zinc females having lower levels. concentration negative age, older chronic cardiac issues high blood pressure exhibited these markers. severity also had detrimental impact electrolyte levels, cases showing complications such heart failure were associated zinc. Conclusion. In conclusion, revealed associations decreased D3. Sex be correlated Patients Complications

Language: Английский

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Type 2 Myocardial Infarction: Another Hidden Cause of Mortality During the COVID-19 Pandemic

Korean Circulation Journal, Journal Year: 2023, Volume and Issue: 53(12), P. 840 - 840

Published: Jan. 1, 2023

Language: Английский

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