Mogroside Ⅴ Inhibits M1 Polarization and Inflammation of Diabetic Mouse Macrophages via p38 MAPK/NF-Κb Signaling Pathway
Xiaoyi Dong,
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Zhimao Ye,
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Cuiping Li
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et al.
Immunological Investigations,
Journal Year:
2024,
Volume and Issue:
53(4), P. 604 - 621
Published: Feb. 28, 2024
Background
Mogroside
V
(MV)
has
anti-inflammatory
properties.
However,
its
impact
on
macrophage
polarization
under
diabetic
condition
is
yet
unclear.
This
study
aimed
to
investigate
effects
and
underlying
mechanisms
of
MV
inflammatory
response
M1
bone
marrow-derived
macrophages
(BMDMs)
from
mice.
Language: Английский
Effects of N‐acetyl‐L‐cysteine polysulfides on periodontitis in a mouse model
Xinxin Sun,
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Yaru Sun,
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Sumin Cao
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et al.
Immunity Inflammation and Disease,
Journal Year:
2023,
Volume and Issue:
11(8)
Published: Aug. 1, 2023
Polysulfides
are
reported
to
be
involved
in
various
important
biological
processes.
N-acetyl-l-cysteine
polysulfide
with
2
sulfane
sulfur
atoms
(NAC-S2)
regulates
diverse
toll-like
receptor
(TLR)
signaling
pathways.
Here,
we
aimed
determine
the
role
of
NAC-S2
periodontitis
and
explore
potential
mechanism.
Language: Английский
Effects of N‐acetyl‐L‐cysteine against apical periodontitis in rats with adriamycin‐induced cardiomyopathy and nephropathy
Ahmet Özer Şehirli,
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Umut Aksoy,
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Abdullah Sibai
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et al.
International Endodontic Journal,
Journal Year:
2023,
Volume and Issue:
57(2), P. 195 - 207
Published: Dec. 9, 2023
Abstract
Aim
This
study
aimed
to
investigate
the
potential
protective
effects
of
N‐acetyl‐L‐cysteine
(NAC)
against
apical
periodontitis
(AP)
in
rats
with
adriamycin
(ADR)‐induced
kidney
and
heart
diseases.
Methodology
Fourty‐eight
Wistar
albino
were
divided
into
six
groups:
(1)
Control
group,
(2)
ADR
group
(1
mg/kg/day
ip
for
10
days),
(3)
AP
Group
(1st
mandibular
molar
tooth),
(4)
+
Group,
(5)
NAC
(150
ip),
(6)
group.
After
3
weeks,
decapitated
blood
tissue
samples
(heart,
kidney,
jaw)
collected.
Tissue
evaluated
by
biochemical
(inflammatory
cytokines
hemodynamic
parameters)
radiological
analyses.
One‐way
anova
Tukey
post
hoc
tests
was
used
compare
data,
considering
p
<
.05
as
statistically
significant.
Results
The
serum
levels
TNF‐α,
IL‐1β,
BUN,
Creatinine,
CK,
LDH
elevated
test
groups
compared
control
treatment
reduced
these
(
.05).
Heart
analysis
showed
a
higher
heart‐to‐body
weight
ratio
(HW/BW)
kidney‐to‐body
(KW/BW)
No
significant
differences
HW/BW
KW/BW
found
between
groups.
Volumetric
bone
resorption
an
increase
periapical
radiolucencies
AP‐induced
indicating
periodontitis.
total
area
volume
cavities
Conclusions
results
suggest
that
NAC's
antioxidant
anti‐inflammatory
can
reduce
adriamycin‐mediated
damage
may
have
positive
effect
on
individuals
nephropathy
cardiomyopathy.
Language: Английский