Effects of N‐acetyl‐L‐cysteine against apical periodontitis in rats with adriamycin‐induced cardiomyopathy and nephropathy DOI Open Access
Ahmet Özer Şehirli, Umut Aksoy,

Abdullah Sibai

et al.

International Endodontic Journal, Journal Year: 2023, Volume and Issue: 57(2), P. 195 - 207

Published: Dec. 9, 2023

Abstract Aim This study aimed to investigate the potential protective effects of N‐acetyl‐L‐cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)‐induced kidney and heart diseases. Methodology Fourty‐eight Wistar albino were divided into six groups: (1) Control group, (2) ADR group (1 mg/kg/day ip for 10 days), (3) AP Group (1st mandibular molar tooth), (4) + Group, (5) NAC (150 ip), (6) group. After 3 weeks, decapitated blood tissue samples (heart, kidney, jaw) collected. Tissue evaluated by biochemical (inflammatory cytokines hemodynamic parameters) radiological analyses. One‐way anova Tukey post hoc tests was used compare data, considering p < .05 as statistically significant. Results The serum levels TNF‐α, IL‐1β, BUN, Creatinine, CK, LDH elevated test groups compared control treatment reduced these ( .05). Heart analysis showed a higher heart‐to‐body weight ratio (HW/BW) kidney‐to‐body (KW/BW) No significant differences HW/BW KW/BW found between groups. Volumetric bone resorption an increase periapical radiolucencies AP‐induced indicating periodontitis. total area volume cavities Conclusions results suggest that NAC's antioxidant anti‐inflammatory can reduce adriamycin‐mediated damage may have positive effect on individuals nephropathy cardiomyopathy.

Language: Английский

Mogroside Ⅴ Inhibits M1 Polarization and Inflammation of Diabetic Mouse Macrophages via p38 MAPK/NF-Κb Signaling Pathway DOI

Xiaoyi Dong,

Zhimao Ye,

Cuiping Li

et al.

Immunological Investigations, Journal Year: 2024, Volume and Issue: 53(4), P. 604 - 621

Published: Feb. 28, 2024

Background Mogroside V (MV) has anti-inflammatory properties. However, its impact on macrophage polarization under diabetic condition is yet unclear. This study aimed to investigate effects and underlying mechanisms of MV inflammatory response M1 bone marrow-derived macrophages (BMDMs) from mice.

Language: Английский

Citations

3
Effects of N‐acetyl‐L‐cysteine polysulfides on periodontitis in a mouse model DOI Creative Commons
Xinxin Sun, Yaru Sun,

Sumin Cao

et al.

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(8)

Published: Aug. 1, 2023

Polysulfides are reported to be involved in various important biological processes. N-acetyl-l-cysteine polysulfide with 2 sulfane sulfur atoms (NAC-S2) regulates diverse toll-like receptor (TLR) signaling pathways. Here, we aimed determine the role of NAC-S2 periodontitis and explore potential mechanism.

Language: Английский

Citations

3
Effects of N‐acetyl‐L‐cysteine against apical periodontitis in rats with adriamycin‐induced cardiomyopathy and nephropathy DOI Open Access
Ahmet Özer Şehirli, Umut Aksoy,

Abdullah Sibai

et al.

International Endodontic Journal, Journal Year: 2023, Volume and Issue: 57(2), P. 195 - 207

Published: Dec. 9, 2023

Abstract Aim This study aimed to investigate the potential protective effects of N‐acetyl‐L‐cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)‐induced kidney and heart diseases. Methodology Fourty‐eight Wistar albino were divided into six groups: (1) Control group, (2) ADR group (1 mg/kg/day ip for 10 days), (3) AP Group (1st mandibular molar tooth), (4) + Group, (5) NAC (150 ip), (6) group. After 3 weeks, decapitated blood tissue samples (heart, kidney, jaw) collected. Tissue evaluated by biochemical (inflammatory cytokines hemodynamic parameters) radiological analyses. One‐way anova Tukey post hoc tests was used compare data, considering p < .05 as statistically significant. Results The serum levels TNF‐α, IL‐1β, BUN, Creatinine, CK, LDH elevated test groups compared control treatment reduced these ( .05). Heart analysis showed a higher heart‐to‐body weight ratio (HW/BW) kidney‐to‐body (KW/BW) No significant differences HW/BW KW/BW found between groups. Volumetric bone resorption an increase periapical radiolucencies AP‐induced indicating periodontitis. total area volume cavities Conclusions results suggest that NAC's antioxidant anti‐inflammatory can reduce adriamycin‐mediated damage may have positive effect on individuals nephropathy cardiomyopathy.

Language: Английский

Citations

3