Circulating Human Papillomavirus DNA in Head and Neck Squamous Cell Carcinoma: Possible Applications and Future Directions DOI Open Access
Dauren Adilbay,

Saudamini J. Lele,

John Pang

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(23), P. 5946 - 5946

Published: Dec. 1, 2022

There has been a rising trend in HPV-induced head and neck cancers the last several decades. This subgroup of squamous cell carcinoma is mostly located oropharynx comprises subset patients who are typically younger without usual risk factors smoking alcohol use. As prognosis OPC more favorable, there desire to properly select these for de-intensification protocols while identifying individuals may suffer treatment failure. Here, we describe recent developments circulating tumor HPV DNA as marker HPV-positive oropharyngeal cancer that can potentially be used diagnostic tool stratify de-escalation strategies survey recurrence.

Language: Английский

Blood-based screening for HPV-associated cancers DOI Creative Commons

Dipon Das,

Shun Hirayama,

Ling Aye

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 5, 2024

Abstract Background HPV-associated oropharyngeal cancer (HPV+OPSCC) is the most common in United States yet unlike cervical lacks a screening test. HPV+OPSCCs are presumed to start developing 10-15 years prior clinical diagnosis. Circulating tumor HPV DNA (ctHPVDNA) sensitive and specific biomarker for HPV+OPSCC. Taken together, blood-based HPV+OPSCC may be feasible Methods We developed an whole genome sequencing assay, HPV-DeepSeek, with 99% sensitivity specificity at 28 plasma samples from patients collected 1.3-10.8 diagnosis along 1:1 age gender-matched controls were run on HPV-DeepSeek serology assay. Results 22/28 (79%) of cases 0/28 screened positive 100% detection within four maximum lead time 7.8 years. next applied machine learning model classifying 27/28 (96%) 10 Plasma-based PIK3CA gene mutations, viral integration events used orthogonally validate 68% (19/28) cohort having multiple signals detected. Molecular fingerprinting genomes was performed across demonstrating that each unique, ruling out contamination. In blocks (15/28), molecular confirming same time. Conclusions demonstrate accurate cancers times up before doing so, highlight enormous potential ctDNA-based screening.

Language: Английский

Citations

3
Update: Epidemiologie und Prävention des Oropharynxkarzinoms DOI
Andreas Dietz, Gunnar Wichmann, Susanne Wiegand

et al.

Laryngo-Rhino-Otologie, Journal Year: 2024, Volume and Issue: 103(04), P. 296 - 313

Published: April 1, 2024

Beim Oropharynxkarzinom unterscheidet man inzwischen abhängig davon, ob eine HPV-16-Infektion ursächlich vorliegt oder nicht, in 2 verschiedene Entitäten. Neuere Daten zeigen ein diverses Bild der Bedeutung und Prävalenz des Surrogatparameters p16 (Diskordanz) für tatsächliche HPV-16-Assoziation. Im Rahmen Präventionsmöglichkeiten kommt Impfung hohe dem HPV-Screening gesunder Menschen geringe zu.

Citations

3
Addressing positive multi-cancer early detection tests in head and neck Surgery: Experience with head and neck work up for high-risk referrals DOI
Forrest W. Fearington,

Conan Y Zhao,

Santiago Romero‐Brufau

et al.

Oral Oncology, Journal Year: 2024, Volume and Issue: 152, P. 106809 - 106809

Published: April 14, 2024

Language: Английский

Citations

3
Relationship of HPV16 E6 seropositivity with circulating tumor tissue modified HPV16 DNA before head and neck cancer diagnosis DOI
Eleni M. Rettig, Tim Waterboer, Edward S. Sim

et al.

Oral Oncology, Journal Year: 2023, Volume and Issue: 141, P. 106417 - 106417

Published: May 4, 2023

Language: Английский

Citations

7
Circulating Human Papillomavirus DNA in Head and Neck Squamous Cell Carcinoma: Possible Applications and Future Directions DOI Open Access
Dauren Adilbay,

Saudamini J. Lele,

John Pang

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(23), P. 5946 - 5946

Published: Dec. 1, 2022

There has been a rising trend in HPV-induced head and neck cancers the last several decades. This subgroup of squamous cell carcinoma is mostly located oropharynx comprises subset patients who are typically younger without usual risk factors smoking alcohol use. As prognosis OPC more favorable, there desire to properly select these for de-intensification protocols while identifying individuals may suffer treatment failure. Here, we describe recent developments circulating tumor HPV DNA as marker HPV-positive oropharyngeal cancer that can potentially be used diagnostic tool stratify de-escalation strategies survey recurrence.

Language: Английский

Citations

12