Current Opinion in Pediatrics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Purpose of review We provide an overview the secular trend earlier pubertal development, why there is a growing concern that environmental factors may be to blame, and how these influence developing reproductive axis. Recent findings highlight recent work suggesting that, in addition activating sex steroid receptors, compounds neuropeptide receptors and/or epigenetic regulators. describe studies linking air pollution, metals, endocrine disrupting (EDCs), short sleep duration, early life adversity, stress timing. Summary Pubertal timing tightly controlled by genetic, epigenetic, factors. While animal epidemiological have pointed several potential factors, additional necessary identify critical levels developmental windows exposure as well mechanistic underpinnings.

Language: Английский