The Spatial Distribution of Brain Metastasis Is Determined by the Heterogeneity of the Brain Microenvironment DOI Creative Commons
Hongbo Bao, Peng Ren, Xia Liang

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(18)

Published: Dec. 15, 2024

It is now understood that brain metastases do not occur randomly but have distinct spatial patterns depending on the origin of cancer. According to "seed and soil" hypothesis, final colonization metastatic cells result their adaptation altered environment. To investigate most favorable microenvironment for metastasis, we analyzed neuroimaging data from 177 patients with breast cancer metastasis 548 lung create a replicable probabilistic map locations. Additionally, used population-based open repositories generate atlases diverse features, including gene expression, functional connectivity, glucose metabolism, neurotransmitter transporters/receptors. We then compared correlation between frequency these after which constructed general linear model identify significant variables contributed tumor location predilection. Our findings revealed had radiographic characteristics distribution patterns. Breast tended metastasize in regions decreased expression genes associated immunity metabolism reduced levels connectomic hubness metabolism. In contrast, higher probability metastasizing active Moreover, systems play various roles determining location. These results provide new insights into illustrate how factors biological scales can affect metastases.

Language: Английский

Quantitative evaluation of neuroradiological and morphometric alteration of inferior Fronto-Occipital Fascicle across different brain tumor histotype: an Italian multicentric study DOI Creative Commons
Roberto Altieri, Andrea Bianconi, Stefano Caneva

et al.

Acta Neurochirurgica, Journal Year: 2025, Volume and Issue: 167(1)

Published: March 12, 2025

Abstract Background Inferior Fronto-Occipital Fascicle (IFOF) is a multitasking connection bundle essential for communication and high level mentalization. The aim of the present study was to quantitatively assess its radiological-anatomical-morphometric modifications according different brain tumor histotype. Methods A retrospective multicentric Italian conducted. IFOF reconstructions were calculated both hemispheres each patient diagnosed with Glioblastoma (GBM), Low Grade Glioma (LGG), Brain Metastasis Meningioma using Elements Fibertracking software (Brainlab AG). 3D object fascicle evaluated volume, average fractional anisotropy (FA) length. cerebral healthy hemisphere compared pathological contralateral in Results 1294 patients evaluated. 156 met inclusion criteria. We found significant difference between mean length volume ( p -value < 0.001). Considering GBM subgroup, Student’s t-test confirmed results. In LGG there 2 length, FA (respectively 0.011; 0.021, affected by metastasis (18) showed 0.003 0.02 respectively). No differences meningiomas. Conclusions careful preoperative neuroradiological evaluation brain-tumor interface indispensable plan tailored surgical strategy perform safe effective technique. It depends on histology pattern growth. have mixed component, solid enhancing nodule which accounts displacement peritumoral area an infiltrative/destructive effect fascicle. determine prevalent infiltrative pattern. Metastases dislocation due oedema. Meningiomas do not impact WM anatomy.

Language: Английский

Citations

0
Sonodynamic Therapy Using 5-Aminolevulinic Acid for Malignant Gliomas: A Review DOI Creative Commons

Andrea Ebeling,

Francesco Prada

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 718 - 718

Published: April 29, 2025

In recent years, sonodynamic therapy (SDT) has attracted attention as a promising new approach for the treatment of high-grade gliomas, it is non-invasive form that specifically kills tumor cells with limited side effects. SDT combines low-intensity ultrasound sonosensitizer to produce cytotoxic effects in cells. 5-Aminolevulinic acid (5-ALA), an endogenous amino metabolized protoporphyrin IX (PpIX), shown promise malignant gliomas SDT. Ultrasound can penetrate deeper body regions and activate PpIX, leading increase immunogenicity induction apoptosis. This review highlights current state knowledge on mechanisms action, results preclinical, clinical ongoing studies 5-ALA-SDT discusses future benefits

Language: Английский

Citations

0
The Spatial Distribution of Brain Metastasis Is Determined by the Heterogeneity of the Brain Microenvironment DOI Creative Commons
Hongbo Bao, Peng Ren, Xia Liang

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(18)

Published: Dec. 15, 2024

It is now understood that brain metastases do not occur randomly but have distinct spatial patterns depending on the origin of cancer. According to "seed and soil" hypothesis, final colonization metastatic cells result their adaptation altered environment. To investigate most favorable microenvironment for metastasis, we analyzed neuroimaging data from 177 patients with breast cancer metastasis 548 lung create a replicable probabilistic map locations. Additionally, used population-based open repositories generate atlases diverse features, including gene expression, functional connectivity, glucose metabolism, neurotransmitter transporters/receptors. We then compared correlation between frequency these after which constructed general linear model identify significant variables contributed tumor location predilection. Our findings revealed had radiographic characteristics distribution patterns. Breast tended metastasize in regions decreased expression genes associated immunity metabolism reduced levels connectomic hubness metabolism. In contrast, higher probability metastasizing active Moreover, systems play various roles determining location. These results provide new insights into illustrate how factors biological scales can affect metastases.

Language: Английский

Citations

0