Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation DOI Creative Commons
Peng Shi, Simin Xu, Ziling Yang

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests link between the microbiome and aging, hinting at its potential role longevity. However, understanding relationship challenging due to microbiota's complexity. This perspective summarizes mechanisms by which microbes regulate host lifespan explores genetic manipulation strategies promote healthy aging elderly.

Language: Английский

Artificial intelligence for life sciences: A comprehensive guide and future trends DOI

Ming Luo,

Wenyu Yang, Long Bai

et al.

The Innovation Life, Journal Year: 2024, Volume and Issue: unknown, P. 100105 - 100105

Published: Jan. 1, 2024

<p>Artificial intelligence has had a profound impact on life sciences. This review discusses the application, challenges, and future development directions of artificial in various branches sciences, including zoology, plant science, microbiology, biochemistry, molecular biology, cell developmental genetics, neuroscience, psychology, pharmacology, clinical medicine, biomaterials, ecology, environmental science. It elaborates important roles aspects such as behavior monitoring, population dynamic prediction, microorganism identification, disease detection. At same time, it points out challenges faced by application data quality, black-box problems, ethical concerns. The are prospected from technological innovation interdisciplinary cooperation. integration Bio-Technologies (BT) Information-Technologies (IT) will transform biomedical research into AI for Science paradigm.</p>

Language: Английский

Citations

7

Trace Element Exposure during Pregnancy Has a Persistent Influence on Perinatal Gut Microbiota in Mother–Infant Dyads DOI
Yuqing Zhang, Yang Xu, Chao Dong

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Trace elements have been recognized as the modifiers of gut microbiota. However, population-based evidence about their effects on maternal microbiota dynamics, well intergenerational impacts neonatal microbiota, has lacking. We examined longitudinal data from mother-infant dyads and demonstrated that trace element exposure played a pivotal role in shaping composition similarity Specifically, serum levels cobalt (Co), molybdenum (Mo), rubidium (Rb) were identified to cause further fluctuation shift Antibiotic usage shortly before or delivery day, zinc (Zn) exposure, affected within dyads. Rb an effect meconium Bifidobacterium abundance by altering its gut. Notably, this was strengthened vaginal group without antibiotic usage, while it attenuated c-section group. Our results suggest persistent influence perinatal which offers novel insights into promoting mother infant health.

Language: Английский

Citations

0

In vivo detection of endogenous toxic phenolic compounds of intestine DOI

Wenyu Jin,

Jiaxin Guo,

Rongkang Tang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135526 - 135526

Published: Aug. 14, 2024

Language: Английский

Citations

3

Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation DOI Creative Commons
Peng Shi, Simin Xu, Ziling Yang

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests link between the microbiome and aging, hinting at its potential role longevity. However, understanding relationship challenging due to microbiota's complexity. This perspective summarizes mechanisms by which microbes regulate host lifespan explores genetic manipulation strategies promote healthy aging elderly.

Language: Английский

Citations

1