Unveiling the role of phages in shaping the periodontal microbial ecosystem

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT The oral microbiome comprises various species and plays a crucial role in maintaining the ecosystem host health. Phages are an important component of periodontal microbiome, yet our understanding phages remains limited. Here, we investigated using advanced bioinformatics tools based on genomes key periodontitis pathogens. Prophages were found to encode auxiliary genes that potentially enhance survival pathogenicity, including involved carbohydrate metabolism, antibiotic resistance, immune modulation. We observed cross-species transmission among prophages with complex network phage-bacteria interactions. Our findings suggest play shaping microbial ecosystem, influencing community dynamics progression periodontitis. IMPORTANCE In context periodontitis, ecological largely driven by interactions between bacteria their phages. While impact regulating pathogens has been increasingly recognized, modulating disease underexplored. This study reveals within contribute significantly virulence factor dissemination, metabolism. By metabolic capabilities strategies bacterial hosts, may act as critical regulators communities cavity. Understanding these prophage-mediated is essential not only for unraveling mechanisms but also developing innovative therapeutic approaches target at genetic level. These insights emphasize need more comprehensive studies risks posed pathogenicity resistance.

Language: Английский

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Detection and analysis of sow nursing behavior based on the number and location of piglets outside the suckling area using YOLOv5s

Computers and Electronics in Agriculture, Journal Year: 2025, Volume and Issue: 235, P. 110324 - 110324

Published: April 5, 2025

Language: Английский

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Polyketides with Cardioprotective Bioactivities from Sponge-Associated Fungus Aspergillus giganteus MA46-5

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1632 - 1632

Published: April 6, 2025

One pair of novel enantiomers, gigantdioxin A (+)-1 and B (−)-1, with a skeleton benzo[d][1,3]dioxin; new acetophenone gigantone (3); known 3-chlorogentisyl alcohol (2), which is the bioprecursor 1; (4); chromone derivative (5) were obtained from sponge-associated fungus Aspergillus giganteus MA46-5. Their structures established by extensive in-depth spectral analysis, such as UV, 1D 2D NMR, HRESIMS. The absolute configurations (±)-1 deduced ORD, chiral separation, experimental computational ECD. Meanwhile, we proposed possible biosynthetic pathway (±)-1. Fortunately, was proved biomimetic synthesis through 2, bioprecursor, reacted n-butyraldehyde. Myocardial protection assays showed that 3 4 possessed stronger protective effects than positive control against myocardial cell H9c2 ischemia–reperfusion injury in low concentrations, effect (−)-1 almost equal to control. Further, explored mechanism network pharmacology. Adenosine A2a receptor (ADORA2A) serum albumin (ALB) represent potential targets for associated 4, respectively. Based on pharmacology, docked predicted proteins bioactive compounds using Autodock Vina.

Language: Английский

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Deciphering of electron transfer and microbial community of electrogenic oxygen reducing biofilms to sulfamethoxazole stress

Bioresource Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132597 - 132597

Published: April 1, 2025

Language: Английский

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Diversity, influential factor, and communication network construction of quorum sensing bacteria in global wastewater treatment plants

Water Research, Journal Year: 2025, Volume and Issue: 279, P. 123437 - 123437

Published: March 6, 2025

Language: Английский

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