Intrinsic anti-inflammatory nanomedicines for enhanced pain management DOI Creative Commons
Bin Qiao,

Jiaqian Yao,

Yuhua Fan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 16, 2024

Effective postoperative pain management remains a significant challenge due to the severe side effects of opioids and limitations existing analgesic delivery systems. Inflammation plays critical role in exacerbation, highlighting need for therapies that combine with intrinsic anti-inflammatory properties.

Language: Английский

cGAS-mediated Antibacterial Immunotherapy Against Tuberculosis by Macrophage-Targeted Manganese Dioxide Nanoagonist DOI

Kangsheng Liao,

Ruihong Chen, Jinwei Zhang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
NIR-triggered and Glucose-Powered Hollow mesoporous Mo-based single-atom nanozymes for cascade chemodynamic diabetic infection therapy DOI Creative Commons
Jingwei Wang, Yu Yin, Lingzhi Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101557 - 101557

Published: Feb. 5, 2025

Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.

Language: Английский

Citations

0
A computer-aided, carrier-free drug delivery system with enhanced cytotoxicity and biocompatibility: a universal model for multifunctional lung cancer therapy DOI
Zhonglei Wang,

Wenjing Xu,

Shizeng Lei

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114557 - 114557

Published: Feb. 9, 2025

Language: Английский

Citations

0
Natural Turmeric‐Derived Nanovesicles‐Laden Metal‐Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual‐Repair Strategy DOI

Mingzhen Zhong,

Tong Liao,

Zehan Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Skin barrier impairment is critical in the development of atopic dermatitis (AD), increasing vulnerability to external pathogens and disrupting cell metabolism, which leads inflammatory stress immune imbalance. In this study, a natural turmeric‐derived nanovesicle (TDNV)‐laden metal polyphenol hydrogel, termed Fe‐HD@TDNV proposed, synergistically restore compromised skin AD through dual‐repair strategy. The TDNV effectively regulates metabolic activity by upregulating expression proteins, antioxidant enzymes, antimicrobial peptides (AMPs) keratinocytes, thereby reinforcing integrity combating pathogens. Simultaneously, Fe‐HD cross‐linked Fe 3 ⁺ ions hyaluronic acid‐graft‐dopamine (HD), provides superior compatibility establishes low oxidative environment for potentiating therapeutic efficacy TDNV. By improving conditions, hydrogel exhibited desirable performance maintaining better hydration, reducing epidermal thickness, decreasing abnormal responses acute disruption models models. This work expected offer insights into cross‐kingdom regulation between plant‐derived nanovesicles mammals, as well design disease‐specific dual‐functional repair strategies.

Language: Английский

Citations

0
New targets for the treatment of ulcerative colitis: gut microbiota and its metabolites DOI Creative Commons

Huanyu Li,

Meng Pan, Yifan Li

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
The pharmacodynamic and pharmacological mechanisms underlying nanovesicles of natural products: Developments and challenges DOI
Junzhe Zhang, Huanhuan Pang, Huan Tang

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 265, P. 108754 - 108754

Published: Nov. 18, 2024

Language: Английский

Citations

2
Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats DOI Open Access
Roberta Gasparro, Giuditta Gambino,

Giulia Duca

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117532 - 117532

Published: Oct. 8, 2024

Language: Английский

Citations

1
Proteomic analysis of plasma and duodenal tissue in celiac disease patients reveals potential noninvasive diagnostic biomarkers DOI Creative Commons
Na Na Li,

Ayinuer Maimaitireyimu,

Tian Shi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 2, 2024

The pathogenesis of celiac disease (CeD) remains incompletely understood. Traditional diagnostic techniques for CeD include serological testing and endoscopic examination; however, they have limitations. Therefore, there is a need to identify novel noninvasive biomarkers diagnosis. We analyzed duodenal plasma samples from patients by four-dimensional data-dependent acquisition (4D-DIA) proteomics. Differentially expressed proteins (DEPs) were identified functional analysis propose blood associated with In samples, respectively, 897 140 DEPs identified. Combining weighted gene co-expression network analysis(WGCNA) the DEPs, five key across three machine learning methods. FGL2 TXNDC5 significantly elevated in group, while CHGA expression showed an increasing trend, but without statistical significance. receiver operating characteristic curve results indicated area under (AUC) 0.7711 0.6978 TXNDC5, combined AUC 0.8944. Exploratory using Mfuzz methods four potentially pathological grading (Marsh classification): FABP, CPOX, BHMT, PPP2CB. conclude that deserve exploration as potential sensitive, CeD.

Language: Английский

Citations

0
Intrinsic anti-inflammatory nanomedicines for enhanced pain management DOI Creative Commons
Bin Qiao,

Jiaqian Yao,

Yuhua Fan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 16, 2024

Effective postoperative pain management remains a significant challenge due to the severe side effects of opioids and limitations existing analgesic delivery systems. Inflammation plays critical role in exacerbation, highlighting need for therapies that combine with intrinsic anti-inflammatory properties.

Language: Английский

Citations

0