Methylation modification of non-histone proteins in breast cancer: An emerging targeted therapeutic strategy DOI Creative Commons
Mingyao Huang,

Zirong Jiang,

Yadan Xu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107354 - 107354

Published: Aug. 17, 2024

Breast cancer is a major public health concern worldwide, being the most commonly diagnosed among women and leading cause of cancer-related deaths. Recent studies have highlighted significance non-histone methylation in breast cancer, which modulates activity, interaction, localization, stability target proteins. This regulation affects critical processes such as oncogenesis, tumor growth, proliferation, invasion, migration, immune responses. review delves into enzymes responsible for methylation, protein arginine methyltransferases (PRMTs), lysine (KMTs), demethylases, explores their roles cancer. By elucidating molecular mechanisms functional consequences this aims to provide insights novel therapeutic strategies targeting these pathways. The potential overcome drug resistance enhance treatment efficacy also discussed, highlighting promising avenues future research clinical applications.

Language: Английский

The Pleiotropic Effects of Lipid-Modifying Interventions: Exploring Traditional and Emerging Hypolipidemic Therapies DOI Creative Commons
Dimitris Kounatidis, Nikolaοs Tentolouris, Natalia G. Vallianou

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 388 - 388

Published: July 17, 2024

Atherosclerotic cardiovascular disease poses a significant global health issue, with dyslipidemia standing out as major risk factor. In recent decades, lipid-lowering therapies have evolved significantly, statins emerging the cornerstone treatment. These interventions play crucial role in both primary and secondary prevention by effectively reducing through lipid profile enhancements. Beyond their effects, extensive research indicates that these exhibit pleiotropic actions, offering additional benefits. include anti-inflammatory properties, improvements vascular glucose metabolism, potential implications cancer management. While ezetimibe been extensively studied, newer agents also demonstrate similar even absence of direct This narrative review explores diverse properties lipid-modifying therapies, emphasizing non-lipid effects contribute to burden exploring benefits for non-cardiovascular conditions. Mechanistic insights into actions are discussed alongside therapeutic implications.

Language: Английский

Citations

4
Cholesterol metabolism: A strategy for overcoming drug resistance in tumors DOI
Jiahui Li, Yinping Guo, Wenjie Zhang

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 238, P. 116974 - 116974

Published: May 9, 2025

Language: Английский

Citations

0
The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy DOI Creative Commons

Meng-Jie Zhang,

Yan Wen, Zhi‐Jun Sun

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 13, 2025

Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.

Language: Английский

Citations

0
Genetic association of lipids and lipid-lowering drug target genes with Endometrial carcinoma: a drug target Mendelian randomization study DOI Creative Commons

Zhe-Han Yang,

Jun-Pan Chen,

Ming-Hao Wen

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

Background Aberrant lipid metabolism is intricately linked to the development of endometrial cancer, and statin lipid-lowering medications are regarded as promising adjunctive therapies for future management this malignancy. This study employed Mendelian randomization (MR) explore causal association between traits cancer while assessing potential impact drug targets on lower lipids cancer. Method Two-sample was probe carcinoma. Drug-target also utilized identify drug-target genes managing In instances where lipid-mediated effects through particular were notable, impacts these carcinoma risk factors investigated bolster findings. Result No genetically predicted (LDL-C, TG, TC, HDL-C) EC found in two-sample randomization. target randomization, genetic modeling apolipoprotein B (APOB) (OR [95%CI]=0.31, [0.16-0.60]; p =4.73e-04) cholesteryl ester transfer protein (CETP) [95%CI]=1.83, [1.38-2.43]; =2.91e-05) mimicry associated with non-endometrioid Conclusion The results our MR revealed no EC. Among six targets, we observed a significant APOB levels higher CETP an increased endometrioid These findings provide novel insights into importance regulation individuals carcinoma, warranting further clinical validation mechanistic investigations.

Language: Английский

Citations

1
Methylation modification of non-histone proteins in breast cancer: An emerging targeted therapeutic strategy DOI Creative Commons
Mingyao Huang,

Zirong Jiang,

Yadan Xu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107354 - 107354

Published: Aug. 17, 2024

Breast cancer is a major public health concern worldwide, being the most commonly diagnosed among women and leading cause of cancer-related deaths. Recent studies have highlighted significance non-histone methylation in breast cancer, which modulates activity, interaction, localization, stability target proteins. This regulation affects critical processes such as oncogenesis, tumor growth, proliferation, invasion, migration, immune responses. review delves into enzymes responsible for methylation, protein arginine methyltransferases (PRMTs), lysine (KMTs), demethylases, explores their roles cancer. By elucidating molecular mechanisms functional consequences this aims to provide insights novel therapeutic strategies targeting these pathways. The potential overcome drug resistance enhance treatment efficacy also discussed, highlighting promising avenues future research clinical applications.

Language: Английский

Citations

0