The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors DOI Creative Commons
Jorge Gutiérrez–Cuevas, Marina Galicia‐Moreno, Hugo Christian Monroy-Ramírez

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 235 - 235

Published: Jan. 26, 2022

The raising prevalence of obesity is associated with an increased risk for cardiovascular diseases (CVDs), particularly coronary artery disease (CAD), and heart failure, including atrial fibrillation, ventricular arrhythmias sudden death. Obesity contributes directly to incident factors, hyperglycemia or diabetes, dyslipidemia, hypertension, which are involved in atherosclerosis, structural functional cardiac alterations, lead dysfunction. CVDs the main cause morbidity mortality worldwide. In obesity, visceral epicardial adipose tissue generate inflammatory cytokines reactive oxygen species (ROS), induce oxidative stress contribute pathogenesis CVDs. Nuclear factor erythroid 2-related 2 (NRF2; encoded by Nfe2l2 gene) protects against electrophilic stress. NRF2 participates regulation cell responses lipid metabolism, expression over 1000 genes under normal stressed environments. downregulated inflammation. knockout mice develop deficiency macrophages increases atherosclerosis. Given endothelial protective effects experimental models, its activation using pharmacological natural products a promising therapeutic approach This review provides comprehensive summary current knowledge on role obesity-associated factors.

Language: Английский

Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution DOI
Rui Chen, Bin Hu, Ying Liu

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2016, Volume and Issue: 1860(12), P. 2844 - 2855

Published: March 16, 2016

Language: Английский

Citations

361
Triboelectric Nanogenerator Enhanced Nanofiber Air Filters for Efficient Particulate Matter Removal DOI

Guang Qin Gu,

Chang Bao Han,

Cun Xin Lu

et al.

ACS Nano, Journal Year: 2017, Volume and Issue: 11(6), P. 6211 - 6217

Published: May 10, 2017

We developed a high-efficiency rotating triboelectric nanogenerator (R-TENG) enhanced polyimide (PI) nanofiber air filter for particulate matter (PM) removal in ambient atmosphere. The PI electrospinning film exhibited high efficiency the PM particles that have diameters larger than 0.5 μm. When R-TENG is connected, of enhanced, especially when particle are smaller 100 nm. highest 90.6% with diameter 33.4 nm and enhancement reaches 207.8% at 76.4 where from 27.1% to 83.6%. This technology zero ozone release low pressure drop offers an approach cleaning haze treatment.

Language: Английский

Citations

274
Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors DOI Open Access
Oriol Juanola, Sebastián Martínez‐López, Rubén Francés

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(10), P. 5227 - 5227

Published: May 14, 2021

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes chronic in Western world, probably due to growing prevalence obesity, metabolic diseases, and exposure some environmental agents. In certain patients, simple hepatic steatosis can progress non-alcoholic steatohepatitis (NASH), which sometimes lead cirrhosis its complications including hepatocellular carcinoma. Understanding mechanisms that cause progression NAFLD NASH crucial be able control advancement disease. The main hypothesis considers it multiple factors act together on genetically predisposed subjects suffer from insulin resistance, nutritional factors, gut microbiota, genetic epigenetic factors. this article, we will discuss epidemiology NAFLD, overview several topics influence development possible complications.

Language: Английский

Citations

211
Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway DOI Creative Commons
Jian Wang, Jian-An Huang, Linlin Wang

et al.

Journal of Thoracic Disease, Journal Year: 2017, Volume and Issue: 9(11), P. 4398 - 4412

Published: Nov. 1, 2017

Background: Particulate matter (PM) is a high risk factor for various respiratory diseases and triggers an inflammatory response in lung tissues. However, the molecular mechanism of PM-induced incompletely understood.

Language: Английский

Citations

210
Oxidative stress and the cardiovascular effects of air pollution DOI Creative Commons
Mark R. Miller

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 151, P. 69 - 87

Published: Jan. 7, 2020

Cardiovascular causes have been estimated to be responsible for more than two thirds of the considerable mortality attributed air pollution. There is now a substantial body research demonstrating that exposure pollution has many detrimental effects throughout cardiovascular system. Multiple biological mechanisms are responsible, however, oxidative stress prominent observation at levels impairment induced by pollutant exposure. This review provides an overview evidence key pathway different actions

Language: Английский

Citations

197
PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway DOI Creative Commons

Chen‐Wei Liu,

Tzu-Lin Lee,

Yu‐Chen Chen

et al.

Particle and Fibre Toxicology, Journal Year: 2018, Volume and Issue: 15(1)

Published: Jan. 12, 2018

Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of damages cells. However, the mechanisms remain to be elucidated. This study examines effects PMs on intercellular adhesion molecule-1 (ICAM-1) expression related in vitro vivo.The cytotoxicity, reactive oxygen species (ROS) generation, monocyte adherence A549 cells were more severely affected by treatment O-PMs (organic solvent-extractable fraction SRM1649b) than W-PMs (water-soluble SRM1649b). We observed a significant increase ICAM-1 O-PMs, but not W-PMs. also induced phosphorylation AKT, p65, STAT3. Pretreating N-acetyl cysteine (NAC), an antioxidant, attenuated O-PMs-induced ROS mentioned kinases, ICAM-1. Furthermore, AKT inhibitor (LY294002), NF-κB (BAY11-7082), STAT3 (Stattic) significantly down-regulated as well U937 epithelial Interleukin-6 (IL-6) was most changed cytokine O-PMs-treated according analysis antibody array. The IL-6 receptor tocilizumab (TCZ) small interfering RNA for reduced secretion reduction In addition, intratracheal instillation levels tissues plasma WT mice, knockout mice. Pre-administration NAC those PMs-induced adverse patients chronic obstructive pulmonary disease (COPD) had higher compared healthy subjects.These results suggest vivo through IL-6/AKT/STAT3/NF-κB signaling pathway.

Language: Английский

Citations

193
In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression DOI Open Access
Ching-Chang Cho,

Wen-Yeh Hsieh,

Chin-Hung Tsai

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2018, Volume and Issue: 15(7), P. 1380 - 1380

Published: July 1, 2018

Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) type of air that comprises heterogeneous mixture different particle sizes and chemical compositions. There are various sources fine PM (PM2.5), the components may also have effects on people. The pathogenesis PM2.5 several diseases remains to be clarified. long history epidemiological research diseases. Numerous studies show can induce variety chronic diseases, such as respiratory system damage, cardiovascular dysfunction, diabetes mellitus. However, evidence associated with potential mechanisms progression need proved precisely through vitro vivo investigations. Suggested lead adverse include increasing oxidative stress, inflammatory responses, genotoxicity. aim this review provide brief overview experimental from last decade. summarized results could clear information about PM2.5-induced disease.

Language: Английский

Citations

178
Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans DOI Open Access
Zhanghua Chen, Muhammad T. Salam, Claudia M. Toledo‐Corral

et al.

Diabetes Care, Journal Year: 2016, Volume and Issue: 39(4), P. 547 - 554

Published: Feb. 11, 2016

OBJECTIVE Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized adversely affects insulin sensitivity secretion serum lipid levels. RESEARCH DESIGN AND METHODS Participants were selected from BetaGene (n = 1,023), study of resistance pancreatic β-cell function Mexican Americans. All participants underwent DXA oral intravenous glucose tolerance tests completed dietary physical activity questionnaires. Ambient pollutant concentrations (NO2, O3, PM2.5) for short- long-term periods assigned by spatial interpolation (maximum radius 50 km) data quality monitors. Traffic-related freeways (TRAP) was estimated using the dispersion model as NOx. Variance component models used analyze individual multiple associations with metabolic traits. RESULTS Short-term (up 58 days cumulative lagged averages) exposure PM2.5 associated lower HDL-to-LDL cholesterol ratio higher fasting insulin, HOMA-IR, total cholesterol, LDL (LDL-C) (all P ≤ 0.036). Annual average glucose, LDL-C (P 0.043). effects short-term on largest among obese participants. No statistically significant found between TRAP outcomes. CONCLUSIONS Exposure ambient pollutants tolerance, sensitivity, blood concentrations. Our findings may contribute pathophysiology development T2D related sequelae.

Language: Английский

Citations

157
Role of oxidative stress in cardiovascular disease outcomes following exposure to ambient air pollution DOI Creative Commons
Frank J. Kelly, Julia C. Fussell

Free Radical Biology and Medicine, Journal Year: 2017, Volume and Issue: 110, P. 345 - 367

Published: June 29, 2017

Exposure to ambient air pollution is associated with adverse cardiovascular outcomes. These are manifested through several, likely overlapping, pathways including at the functional level, endothelial dysfunction, atherosclerosis, pro-coagulation and alterations in autonomic nervous system balance blood pressure. At numerous points within each of these pathways, there potential for cellular oxidative imbalances occur. The current review examines epidemiological, occupational controlled exposure studies research employing healthy diseased animal models, isolated organs cell cultures assessing importance pro-oxidant development disease collective body data provides evidence that stress (OS) not only central eliciting specific cardiac endpoints, but also implicated modulating risk succumbing disease, sensitivity ischemia/reperfusion injury onset progression metabolic following exposure. To add this large effort conducted date, further work required provide greater insight into areas such as (a) whether an imbalance triggers and/or worsens effect representative consequence progression, (b) OS outcomes caused by individual pollutants mixtures, or a inter-pollutant interactions (c) protection provided nutritional supplements pharmacological agents antioxidant properties, susceptible populations residing polluted urban cities.

Language: Английский

Citations

153
Direct effects of airborne PM2.5 exposure on macrophage polarizations DOI
Qingjie Zhao, Hui Chen, Tao Yang

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2016, Volume and Issue: 1860(12), P. 2835 - 2843

Published: April 16, 2016

Language: Английский

Citations

129