Copper homeostasis and pregnancy complications: a comprehensive review

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

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The Role of Autophagy in Copper-Induced Apoptosis and Developmental Neurotoxicity in SH-SY5Y Cells

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 63 - 63

Published: Jan. 17, 2025

Copper (Cu) is a global environmental pollutant that poses serious threat to humans and ecosystems. induces developmental neurotoxicity, but the underlying molecular mechanisms are unknown. Neurons nonrenewable, they unable mitigate excessive accumulation of pathological proteins organelles in cells, which can be ameliorated by autophagic degradation. In this study, we established an vitro model Cu2+-exposed (0, 15, 30, 60 120 μM) SH-SY5Y cells explore role autophagy copper-induced neurotoxicity. The results showed copper resulted reduction shortening neural synapses differentiated cultured downregulated Wnt signaling pathway, nuclear translocation β-catenin. Exposure Cu2+ increased autophagosome flux blockage terms sequestosome 1 (p62/SQSTM1) microtubule-associated protein light chain 3B (LC3B) II/LC3BI expressions inhibition phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway. Furthermore, induced apoptosis, characterized Bcl2 X (Bax), caspase 3, Poly (ADP-ribose) polymerase (PARP) decreased expression B-cell lymphoma 2 (Bcl2). Compared with μM exposure group alone, activator rapamycin pretreatment β-catenin translocation, LC3BII/LC3BI p62, as well upregulated 3 PARP. contrast, after inhibitor chloroquine pretreatment, were decreased, levels p62 upregulated, was while Bax, PARP increased. conclusion, study demonstrated associated neurotoxicity via might deepen understanding mechanism exposure.

Language: Английский

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Decoration of copper nanoparticles (Cu2O NPs) over chitosan-guar gum: Its application in the Sonogashira cross-coupling reactions and treatment of human lung adenocarcinoma

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141122 - 141122

Published: Feb. 16, 2025

Language: Английский

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Antiapoptotic Properties of Zinc@Curcumin‐Chitosan Nanocomposite on SW‐626 Ovarian Cancer Cell and Following the PI3K/AKT/mTOR Signaling Pathway

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 10, 2025

ABSTRACT Curcumin is a natural compound found in turmeric. It strong antioxidant that helps combat oxidative stress. also known as an effective agent for cancer therapy. In this study, we have reported green synthesis of zinc nanoparticles using extracted curcumin from turmeric and chitosan to modify the NPs surface. The synthesized were characterized different techniques. XRD results revealed crystallinity structure with crystal size 45.93 nm. FE‐SEM imaging shows nonspherical morphology average 62.41 vibration bands Zn‐O bonds are appearance at 428, 534, 580 cm −1 FT‐IR test. biological aspects focus recent study. Over course 48 h, MTT test was used evaluate cytotoxic capacities Zn on SW‐626 HUVEC normal cells. Also, appraisement IC 50 butylated hydroxytoluene (BHT; positive control DPPH assay) relation 41 15 μg/mL, respectively. When exposed NPs, cell's viability decreased, resulting 170 μg/mL. report mTOR pathway indicated influence apoptosis cell proliferation cells through modulation PI3K‐Akt‐mTOR pathway. could be involved activation cycle inhibition brought by NPs. Consequently, may useful anticancer therapeutic ovarian treatments.

Language: Английский

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SGK1 upregulation in GFAP+ neurons in the frontal association cortex protects against neuronal apoptosis after spinal cord injury

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Language: Английский

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