Sources, exposure, metabolism, transportation, ecological effects, preventive measures and alternatives of carcinogenic methylene chloride: a review DOI Creative Commons
Divya Kumari, Pracheta Janmeda, Devendra Singh

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Dec. 23, 2024

Methylene chloride (MC) or dichloromethane (CH2Cl2), a synthetic volatile and carcinogenic compound, is mostly utilized in industries as solvent for metal cleaning, paint stripping, degreasing pharmaceutical manufacturing. Exposure to MC mainly occurs through chemical fume inhalation, accidental ingestion, leakage on the skin. Acute exposure may cause headaches, vomiting, nausea, dizziness, whereas chronic lead carcinogenesis death. It quickly absorbed stomach lungs further dispersed among all body tissues. Then, it metabolized by glutathione-dependent mixed-function oxidase pathways finally eliminated from expiration. Chemical biotransformation of primarily takes place liver, which chemically reactive stable metabolites are formed via two processes, namely, oxidation microsomal cytochrome P-450 conjugation GST. causes numerous toxic effects humans well experimental animal models. Therefore, future research development techniques its proper disposal treatment needed. In this review, clear explanation various routes exposure, different kinds effects, mechanisms toxicity, intoxication, preventive measures alternatives replacement laboratories commercial setups have been discussed.

Language: Английский

Global burden, trends, and disparities in kidney cancer attributable to smoking from 1990 to 2021 DOI Creative Commons

Siyu Han,

Shiyu Zhao, Ran Zhong

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Smoking is a well-established risk factor for kidney cancer. Analyzing the latest global spatio-temporal trends in cancer burden attributable to smoking critical informing effective public health policies. Using data from 2021 GBD database, we examined deaths, disability-adjusted life years (DALYs), and age-standardized rate (ASR) of across global, regional, national levels. Trends ASRs were assessed through estimated annual percentage change (EAPC). We conducted cross-country analysis evaluate disparities 1990 2021, with absolute relative inequalities measured by slope index inequality concentration index, respectively. Correlation was Spearman rank order correlation method. Additionally, projected death DALYs rates up 2036 using Bayesian age-period-cohort (BAPC) models R. Globally, deaths increased 67.64%, 9,673 16,216 2021. Despite this increase, (ASDR) dropped 0.25 0.19 per 100,000 (EAPC: -0.93). Similarly, (ASDALY) decreased 6.17 4.37 -1.15). Geographically, areas higher Socio-demographic Index (SDI) most affected. The positive between SDI highlights role economic social factors disease prevalence. Cross-country shows that while groups are improving, differences burdens continue grow. Furthermore, projections indicate gradual decline ASDR ASDALY both sexes 2022 2036. Between cancer, which positively correlated SDI, have declined. However, significant demographic geographic persist, remaining older populations regions elevated Moreover, overall annually over next 15 years, it expected remain significantly men. These findings emphasize need region-specific prevention strategies reduce smoking-related

Language: Английский

Citations

2
Environmental concentrations of N-nitrosodiethylamine (NDEA) disturb the Ca2 + and K+ homeostasis in the gills and epidermis of mosquitofish (Gambusia affinis) DOI
Xiaoyu Yan, Wenwen Chen, Xiaohong Song

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118067 - 118067

Published: March 27, 2025

Language: Английский

Citations

1
Green-synthesized selenium-hydroxytyrosol nanocomposites attenuate hepatocellular carcinoma in rats by modulating oxidative stress, inflammation, and apoptosis DOI

Radwa Tarek Tawfik,

Eman M Abd El-Azeem,

Sawsan M. El-Sonbaty

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
Apigenin as an emerging hepatoprotective agent: current status and future perspectives DOI Creative Commons
Cheng Wang, Xiaoli Feng, Wen Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Apigenin (C

Language: Английский

Citations

1
Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide DOI Creative Commons
Solomon E. Owumi, Joseph Chimezie,

Praise Dyap Emmanuel

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 25, 2024

Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) DEN-only (200 single dose i.p.). Also, two other rat pre-treated DPDS (3 or 5 mg/kg) for 15 days (day: 0–15), subsequently administered DEN continuously another 7 days, (days:15–21). Behavioural tests (OFT- using open field test; NORT- novel object recognition FST- forced swimming test Y-maze) conducted from 19–21, followed by biochemical analysis hippocampus prefrontal cortex oxidative stress, inflammation, neurotransmitter metabolic enzyme, histopathology. DEN-treated exhibited decreased locomotor activity, spatial memory function antioxidant increased nitration anxiety, depressive-like behaviour, causing histoarchitectural damage hippocampal cortices. treatment (pre- post-DEN exposure) significantly alleviated these neurotoxic, oxidative, effects, reversed histopathological alterations, improved locomotive cognitive functions. In conclusion, demonstrates potent toxicity, likely through enhanced endogenous capacity that mitigates oxido-nitrative damage. These findings suggest organo-selenium -DPDS- promising chemotherapeutic agent alleviating DEN-mediated maintaining brain health.

Language: Английский

Citations

1
Benzo[a]pyrene: A carcinogen, its sources, adverse effects, and preventive measures DOI

Karan Negi,

Priya Chaudhary

The Applied Biology & Chemistry Journal, Journal Year: 2024, Volume and Issue: unknown, P. 44 - 44

Published: Sept. 30, 2024

A polycyclic aromatic hydrocarbon called benzo[a]pyrene (B[a]P) is produced during incomplete burning of fuels. The most common way humans consume B[a]P through food products, particularly grilled or smoked foods. also frequently detected in the sediments, soil, surface water, and air. Once bioactivated, it produces a highly reactive epoxide monomer that can create adducts by chemically reacting with biological molecules, such as DNA. implicated various cancers due to its interaction receptor (AhR). Apart from detrimental impacts on development reproduction, this substance suppresses immune system. Microbes, however, are critical cleaning up B[a]P-contaminated environment. This review focuses forming different compartments environment human surroundings, mechanisms responsible for harmful effects carcinogenic risk. discusses strategies deterioration B[a]P.

Language: Английский

Citations

0
Sources, exposure, metabolism, transportation, ecological effects, preventive measures and alternatives of carcinogenic methylene chloride: a review DOI Creative Commons
Divya Kumari, Pracheta Janmeda, Devendra Singh

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Dec. 23, 2024

Methylene chloride (MC) or dichloromethane (CH2Cl2), a synthetic volatile and carcinogenic compound, is mostly utilized in industries as solvent for metal cleaning, paint stripping, degreasing pharmaceutical manufacturing. Exposure to MC mainly occurs through chemical fume inhalation, accidental ingestion, leakage on the skin. Acute exposure may cause headaches, vomiting, nausea, dizziness, whereas chronic lead carcinogenesis death. It quickly absorbed stomach lungs further dispersed among all body tissues. Then, it metabolized by glutathione-dependent mixed-function oxidase pathways finally eliminated from expiration. Chemical biotransformation of primarily takes place liver, which chemically reactive stable metabolites are formed via two processes, namely, oxidation microsomal cytochrome P-450 conjugation GST. causes numerous toxic effects humans well experimental animal models. Therefore, future research development techniques its proper disposal treatment needed. In this review, clear explanation various routes exposure, different kinds effects, mechanisms toxicity, intoxication, preventive measures alternatives replacement laboratories commercial setups have been discussed.

Language: Английский

Citations

0