Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 13, 2024

Kawasaki disease (KD) is an immune vasculitis of unknown origin, characterized by transient inflammation. The activation the cGAS-STING pathway, triggered mitochondrial DNA (mtDNA) release, has been implicated in onset KD. However, its specific role progression inflammation during KD's acute phase remains unclear.

Language: Английский

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Saikosaponins from Bupleurum scorzonerifolium Willd. alleviates microglial pyroptosis in depression by binding and inhibiting P2 × 7 expression

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156240 - 156240

Published: Nov. 19, 2024

Language: Английский

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A review on the crosstalk between non-coding RNAs and the cGAS-STING signaling pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137748 - 137748

Published: Nov. 19, 2024

Language: Английский

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Mitochondrial DNA Leakage Promotes Persistent Pancreatic Acinar Cell Injury in Acute Pancreatitis via the cGAS-STING-NF-κB Pathway

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Language: Английский

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