A three-dimensional actively spreading bone repair material based on cell spheroids can facilitate the preservation of tooth extraction sockets

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 27, 2023

Introduction: Achieving a successful reconstruction of alveolar bone morphology still remains challenge because the irregularity and complex microenvironment tooth sockets. Biological materials including hydroxyapatite collagen, are used for ridge preservation. However, healing effect is often unsatisfactory. Methods: Inspired by superwetting biomimetic materials, we constructed 3D actively-spreading repair material. It consisted photocurable polyether F127 diacrylate hydrogel loaded with mixed spheroids mesenchymal stem cells (MSCs) vascular endothelial (ECs). Results: Biologically, in were able to spread migrate outwards, possessed both osteogenic angiogenic potential. Meanwhile, ECs also enhanced differentiation MSCs. Mechanically, excellent physical properties F127DA ensured that it was be injected directly into socket stabilized after light curing. In vivo experiments showed MSC-EC-F127DA system promoted preserved shape within short time duration. Discussion: conclusion, novel injectable achieve three-dimensional tissue infiltration, exhibited much therapeutic potential oral defects future.

Language: Английский

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Role of fibrinogen-like 2 (FGL2) proteins in implantation: Potential implications and mechanism

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149284 - 149284

Published: Jan. 1, 2025

Language: Английский

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Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Enterocutaneous fistulas (ECF) are challenging to treat contributing high morbidity and mortality rates, significantly impacting the quality of life patients. Its susceptibility antibiotic‐resistant infections often leads chronic inflammation, complicating treatment with conventional methods. Here, 18NC75‐10P‐1IL is reported, which a multi‐functional shear‐thinning hydrogel comprised gelatin nanosilicates for injectability, an ionic liquid bactericidal effects, platelet rich fibrin fraction pro‐healing properties; this biomaterial engineered ECFs. Through rigorous testing, mechanical properties were tailored catheter injection achieve durable occlusion fistulous tracts under external pressures simulating clinical scenarios. demonstrated effects anti‐microbial activity against highly resistant patient‐derived bacteria known be associated ECF. Subcutaneous implantation anorectal fistula models confirmed its biocompatibility, pro‐healing, anti‐inflammatory, compared control materials, suggesting promising potential translation in human

Language: Английский

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A Comparison of the Sticky Bone Obliteration Technique and Obliteration Using S53P4 Bioactive Glass After Canal Wall Down Ear Surgery: A Preliminary Study

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1681 - 1681

Published: March 1, 2025

Background: The aim of this study was to analyse the results mastoid obliteration technique with sticky bone (SB) and compare them those obtained using bioactive glass S53P4 (BAG). Methods: This prospective preliminary comprised 28 adults who underwent canal wall down (CWD) surgery two obliterative techniques: SB (n = 21) or BAG 7). group treated patients’ own dust injectable platelet rich fibrin (IPRF) 13%) dust, IPRF, additionally allogenic lyophilised demineralised 9%). Results: Nine months after surgery, in group, retroauricular depression observed three (14%) patients, temporary fistula one (5%), a conical smooth external auditory (EAC) achieved 15 (71%). Mean EAC capacity 0.6 mL higher than contralateral ear. In tympanic membrane (TM) nineteen (91%) patients fully healed, (5%) had TM perforation, developed retraction pocket. four (57%) present (14%), five 0.3 on opposite side. we stated six (86%) healed One cholesteatoma found SB, (14% vs. 10%). After 9 months, all both groups dry self-cleaning cavity. Conclusions: Mastoid CWD allows for reconstruction shape volume similar that healthy Both techniques seem have minimal risk complications result dry, Further studies concerning larger series cases are necessary confirm findings analysis.

Language: Английский

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The clinical efficacy of injectable platelet-rich fibrin (i-PRF) as an adjunct to nonsurgical periodontal therapy in smokers with periodontitis

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Smokers with periodontitis generally respond less favorably to nonsurgical treatments compared nonsmokers. Injectable platelet-rich fibrin (i-PRF) is an effective autogenous material that positively influences various biological processes, including inflammation, wound healing, angiogenesis, and regeneration. This split-mouth randomized controlled study aims investigate the effects of subgingival i-PRF application on clinical periodontal parameters as adjunct scaling root planning (SRP) in smokers periodontitis. included twenty-five patients Stage 2 3 Grade C For each patient, four contralateral deep pockets (two for side) were randomly treated SRP + (test group) or saline (control group). Subgingival i-PRF/saline was repeated 7th day, recorded at baseline 1 months following treatments. Compared measurements, both groups presented significant improvements parameters. The probing depth (PD) significantly lower test group than control 1st 3rd (P < 0.05). 3-month gingival index (GI) bleeding (BOP) values No differences observed Turesky modified Quigley-Hein Plaque Index (TQHPI) attachment loss (CAL) score between during follow-up visits > However, greater PD reduction gain found Greater indicate may play a beneficial role improving outcomes treatment ID NCT06605547 ( https://clinicaltrials.gov/ ); September 23, 2024.

Language: Английский

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