Low‐Crosslinked Hydrophilic Decellularized Adipose Matrix Hydrogels Achieve Efficient and Functional Xenotransplant Fat Regeneration by Optimizing Stem Cell Niche

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Xenogeneic decellularized adipose matrix(DAM) scaffolds are significant in soft tissue regeneration by addressing donor site morbidity and limited availability. However, natural DAM xenotransplantation remains unachieved. Previous efforts have relied on chemical modifications to reduce foreign body reactions, with inherent drawbacks outcomes. This study proposes a hydrogel scaffold that achieves efficient functional xenotransplant fat regeneration. Primarily, hydrophilic DAM(H‐DAM) is confirmed lower antigen content, but its regenerative potential constrained encapsulation impedes seed cell infiltration. Thus, H‐DAM prepared enhance the speed extent of It observed topological structure impacts infiltration, immune inflammatory response, Low‐crosslinked hydrogels emerged as optimal for adipogenic differentiation due loose networks degradation rates synchronizing Furthermore, wall‐like rather than filamentous provides superior niche stem engraftment activity. Finally, integrated multi‐omics data analysis demonstrated regenerated functionally mimics native tissue. These findings indicate xenogeneic gel support both structural reconstruction tissue, offering novel insights promising approach clinical translation DAM‐based therapies.

Language: Английский

Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 33 - 54

Published: Nov. 30, 2024

Sufficient vascular system and adequate blood perfusion is crucial for ensuring nutrient oxygen supply within biomaterials. Actively exploring the optimal physical properties of biomaterials in various application scenarios has provided clues enhancing vascularization materials, leading to improved outcomes tissue engineering clinical translation. Here we focus on reviewing biomaterials, including pore structure, surface topography, stiffness, their effects promoting vascularization. This angiogenic capability potential provide better standardized research models personalized treatment strategies bone regeneration, wound healing, islet transplantation cardiac repair.

Language: Английский