Silk Fibroin-Based Antifreezing and Highly Conductive Hydrogel for Sensing at Ultralow Temperature

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Hydrogels with a combination of mechanical flexibility and good electrical conductivity hold significant potential for various applications. Nonetheless, it is inevitable that water-based conductive hydrogels lose their elasticity at extremely low temperatures, severely limiting utilization in ultralow temperature environments, such as those Arctic/Antarctic exploration. In this study, we developed hydrogel based on double network cross-linking strategy incorporated silk fibroin (SF) poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) within lithium bromide (LiBr) solution, which shows exceptional antifreezing (-108 °C freezing point) excellent (16.33 S m-1). The obtained SF/PEDOT:PSS/LiBr (SPL) stable reliable response to wide range deformations (compression: 0.5-60%; tensile: 1.0-100%), short response/recovery time approximately 70 ms. More importantly, the displays well-maintained conductivity, robust properties, dependable sensing capabilities, even under temperatures -80 °C. For proof concept, demonstrated applications SPL detecting body movements, monitoring climate conditions, ensuring information security environments. results indicate promising candidate fabricating flexible sensors, particularly well-suited use challenging scenarios.

Language: Английский

Preparation and Performance Study of Dual-Network Photo-Curable Conductive Silk Fibroin Composite Hydrogel

Materials, Journal Year: 2025, Volume and Issue: 18(4), P. 779 - 779

Published: Feb. 11, 2025

The printing precision of hydrogels directly determines the mechanical and electrical performance scaffolds. In this study, poly(3,4-ethylenedioxythiophene)-poly (styrenesulfonate) (PEDOT:PSS) was compounded with glycidyl methacrylate-modified silk fibroin (Sil-MA) through a one-pot method to increase solid content ink, enhancing its mechanical, electrical, printability properties. A dual-network photo-curable conductive composite hydrogel (CDMA) successfully prepared. results show that introduction PEDOT:PSS significantly improved conductivity hydrogel. (The bandgap decreased from 2.36 eV 1.125 eV, maximum reached 0.534 S/m.) It also enhanced microscopic 3D network density properties (compressive modulus up 192 kPa). Moreover, demonstrated good stability during cyclic testing, providing new approach developing materials capable high-precision stable performance.

Language: Английский

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский