Evaluation of the Structural, Biological, and Bone Induction Properties of Sol–Gel–Derived Lithium‐Doped 68S Bioactive Glass—An in Vitro Study on Human Dental Pulp Stem Cells DOI Creative Commons
Pejman Janbaz, Faeze Behzadpour, Kiana Ghanadan

et al.

Clinical and Experimental Dental Research, Journal Year: 2025, Volume and Issue: 11(3)

Published: April 30, 2025

ABSTRACT Objectives Calcium silicate–based bioactive glass shows enhanced ion release capabilities and promotes the formation of hydroxyapatite (HA). This study aimed to synthesize a sol–gel–derived 68S (BAG) incorporating lithium (Li) evaluate its structural, biological, osteoinductive properties using human dental pulp stem cells (hDPSCs). Materials Methods Two types BAG were synthesized sol–gel method: one containing 5 mol.% nitrate (BGLi5) lithium‐free control (BG). Structural characterization HA assessed field emission scanning electron microscopy (FESEM) Fourier‐transform infrared spectroscopy (FTIR) before after immersion in simulated body fluid (SBF) on Days 1, 3, 7. The dissolution rates specimens evaluated inductively coupled plasma atomic (ICP‐AES) pH analysis. Biological activities investigated through cell viability (MTT assay), alkaline phosphatase (ALP) enzyme activity, alizarin red staining assess mineralization. Additionally, antimicrobial efficacy materials was tested against Streptococcus mutans (SM). Results FTIR FESEM analyses confirmed crystals BGLi5 by Day 3 BG MTT assay demonstrated both compared group. ALP marker differentiation, significantly elevated BGLi5‐DM group 14. Alizarin 21 revealed marked increase mineralization BGLi5, with showing highest levels. Furthermore, significant activity SM . Conclusion Li is biocompatible material that enhances proliferation, combination differentiation‐specific culture medium synergistically osteogenic differentiation mineralization, making it promising candidate for bone tissue engineering applications.

Language: Английский

Fabrication of Piezoelectric/Conductive Composite Nerve Conduits for Peripheral Nerve Regeneration DOI

Taotao Bian,

Yuhui Jiang, Jie Cao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114544 - 114544

Published: Feb. 5, 2025

Language: Английский

Citations

0
Neuromorphic algorithms for brain implants: a review DOI Creative Commons

Wiktoria Agata Pawlak,

Newton Howard

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 11, 2025

Neuromorphic computing technologies are about to change modern computing, yet most work thus far has emphasized hardware development. This review focuses on the latest progress in algorithmic advances specifically for potential use brain implants. We discuss current algorithms and emerging neurocomputational models that, when implemented neuromorphic hardware, could match or surpass traditional methods efficiency. Our aim is inspire creation deployment of that not only enhance computational performance implants but also serve broader fields like medical diagnostics robotics inspiring next generations neural

Language: Английский

Citations

0
Evaluation of the Structural, Biological, and Bone Induction Properties of Sol–Gel–Derived Lithium‐Doped 68S Bioactive Glass—An in Vitro Study on Human Dental Pulp Stem Cells DOI Creative Commons
Pejman Janbaz, Faeze Behzadpour, Kiana Ghanadan

et al.

Clinical and Experimental Dental Research, Journal Year: 2025, Volume and Issue: 11(3)

Published: April 30, 2025

ABSTRACT Objectives Calcium silicate–based bioactive glass shows enhanced ion release capabilities and promotes the formation of hydroxyapatite (HA). This study aimed to synthesize a sol–gel–derived 68S (BAG) incorporating lithium (Li) evaluate its structural, biological, osteoinductive properties using human dental pulp stem cells (hDPSCs). Materials Methods Two types BAG were synthesized sol–gel method: one containing 5 mol.% nitrate (BGLi5) lithium‐free control (BG). Structural characterization HA assessed field emission scanning electron microscopy (FESEM) Fourier‐transform infrared spectroscopy (FTIR) before after immersion in simulated body fluid (SBF) on Days 1, 3, 7. The dissolution rates specimens evaluated inductively coupled plasma atomic (ICP‐AES) pH analysis. Biological activities investigated through cell viability (MTT assay), alkaline phosphatase (ALP) enzyme activity, alizarin red staining assess mineralization. Additionally, antimicrobial efficacy materials was tested against Streptococcus mutans (SM). Results FTIR FESEM analyses confirmed crystals BGLi5 by Day 3 BG MTT assay demonstrated both compared group. ALP marker differentiation, significantly elevated BGLi5‐DM group 14. Alizarin 21 revealed marked increase mineralization BGLi5, with showing highest levels. Furthermore, significant activity SM . Conclusion Li is biocompatible material that enhances proliferation, combination differentiation‐specific culture medium synergistically osteogenic differentiation mineralization, making it promising candidate for bone tissue engineering applications.

Language: Английский

Citations

0