Experimental colitis is comorbid with social interaction deficits and anxiety‐like behaviors in mice: mechanistic intuitions into neuroinflammation and Claudin 5 expression in the hippocampus DOI Open Access
Sepehr Ebrahimi‐Dehkordi, Maryam Anjomshoa, Sorayya Ghasemi

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Inflammatory bowel disease (IBD) is accompanied by psychiatric disorders, including Schizophrenic-like manifestations. Although incompletely illustrated, intestinal mucosal membrane damage and blood-brain barrier (BBB) penetrability may have significant roles in symptoms of IBD. This study aimed to investigate role the Claudin-5 (CLDN5) (a regulator permeability BBB) neuroinflammatory response comorbid behavioral disorders experimental colitis mice. Acetic acid was used induce 7 days after induction colitis, behaviors social interaction locomotor activity as well anxiety-like were evaluated. Then, colon extracted for gross microscopic evaluations. The expression CLDN5, TNF-α, IL1β IL23 measured RT-PCR hippocampus. Histopathologic evaluations demonstrated mucosal, submucosal, crypt-related damages colon. negative positive number interactions significantly increased group. A considerable increase activities (horizontal vertical components) shown Mice group spent less time central zone open field apparatus. Gene expressions IL1β, CLDN5 decreased function intestine brain would be impaired, partially at least, following (as we observed decrease gene expression). Furthermore, found that beside inflammatory colon, a neuro-immune triggered hippocampus colitis. These alterations probably, mediated acetic acid-induced

Language: Английский

Integrated microbiome and metabolomics analysis reveals the alleviating effect of Pediococcus acidilactici on colitis DOI Creative Commons

Lulu Wu,

L. F. Xue,

Xin Ding

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Colitis is a complicated disease caused by multiple factors, seriously threatening the host health and development of animal husbandry. Probiotics have been demonstrate to participate in active regulation gastrointestinal disease, gut microbiota metabolism, but research on efficacy Pediococcus acidilactici isolated from dogs alleviating colitis remains scarce. Here, we aimed investigate ameliorative effects induced LPS its underlying molecular mechanisms. For this purpose, collected colon contents 15 mice for amplicon sequencing metabolic analysis. Results showed that could relieve damage cytokine disorder colitis. Microbiome analysis cause significant decrease microbial diversity abundance, administration restore index control level. Metabolomics 8 pathways 5 (spermine, L-Arginine, 15-Deoxy-Delta12,14-PGJ2, prostaglandin J2, 15(S)-HETE) metabolites may be involved alleviation acidilactici. In summary, these findings demonstrated positive effect metabolism one mechanisms alleviate Additionally, study also conveyed vital message serve as promising candidate ameliorate

Language: Английский

Citations

0
Umbelliprenin attenuates comorbid behavioral disorders in acetic acid-induced colitis in mice: mechanistic insights into hippocampal oxidative stress and neuroinflammation DOI

Negar Hajheidari,

Zahra Lorigooini,

Rohollah Mohseni

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

1
Regulating the NMDA/NR2B signaling pathway mediates anticonvulsant, antineuroinflammation, and anti-oxidative stress effects of 1,3,benzothiazole derivative 1M in pentylenetetrazole-induced kindling in mice DOI
Neelum Gul Qazi, A. Malik, Arooj Mohsin Alvi

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

Citations

0
Experimental colitis is comorbid with social interaction deficits and anxiety‐like behaviors in mice: mechanistic intuitions into neuroinflammation and Claudin 5 expression in the hippocampus DOI Open Access
Sepehr Ebrahimi‐Dehkordi, Maryam Anjomshoa, Sorayya Ghasemi

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Inflammatory bowel disease (IBD) is accompanied by psychiatric disorders, including Schizophrenic-like manifestations. Although incompletely illustrated, intestinal mucosal membrane damage and blood-brain barrier (BBB) penetrability may have significant roles in symptoms of IBD. This study aimed to investigate role the Claudin-5 (CLDN5) (a regulator permeability BBB) neuroinflammatory response comorbid behavioral disorders experimental colitis mice. Acetic acid was used induce 7 days after induction colitis, behaviors social interaction locomotor activity as well anxiety-like were evaluated. Then, colon extracted for gross microscopic evaluations. The expression CLDN5, TNF-α, IL1β IL23 measured RT-PCR hippocampus. Histopathologic evaluations demonstrated mucosal, submucosal, crypt-related damages colon. negative positive number interactions significantly increased group. A considerable increase activities (horizontal vertical components) shown Mice group spent less time central zone open field apparatus. Gene expressions IL1β, CLDN5 decreased function intestine brain would be impaired, partially at least, following (as we observed decrease gene expression). Furthermore, found that beside inflammatory colon, a neuro-immune triggered hippocampus colitis. These alterations probably, mediated acetic acid-induced

Language: Английский

Citations

0