A Haplotype GWAS in Syndromic Familial Colorectal Cancer DOI Open Access
Litika Vermani, Johanna Samola Winnberg, Wen Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 817 - 817

Published: Jan. 19, 2025

A previous genome-wide association study (GWAS) in colorectal cancer (CRC) patients with gastric and/or prostate their families suggested genetic loci a shared risk for these three cancers. second haplotype GWAS was undertaken the same and different controls aim of confirming result finding novel loci. The analysis involved 685 cases 1642 healthy from Sweden. logistic regression model used sliding window approach. Whole-genome exome sequencing datawere to find candidate SNPs be tested nested case-control study. In controls, all ten were confirmed. Fifty p-value < 5 × 10−6 odds ratios between 1.35–6.52. Two 50 loci, on 13q33.3 16q23.3, as or data 122 search variants performed test at 11 cohort 827 familial sub-cohort 293 CRC colorectal, gastric, within 1530 controls. One SNP, rs115943733 10q11.21, reached statistical significance (OR = 3.26, p 0.009). Seven 4 had higher OR smaller compared larger cases. results this gave support an increased CRC, cancer. Further studies are needed confirm able use information prevention.

Language: Английский

A Haplotype GWAS in Syndromic Familial Colorectal Cancer DOI Open Access
Litika Vermani, Johanna Samola Winnberg, Wen Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 817 - 817

Published: Jan. 19, 2025

A previous genome-wide association study (GWAS) in colorectal cancer (CRC) patients with gastric and/or prostate their families suggested genetic loci a shared risk for these three cancers. second haplotype GWAS was undertaken the same and different controls aim of confirming result finding novel loci. The analysis involved 685 cases 1642 healthy from Sweden. logistic regression model used sliding window approach. Whole-genome exome sequencing datawere to find candidate SNPs be tested nested case-control study. In controls, all ten were confirmed. Fifty p-value < 5 × 10−6 odds ratios between 1.35–6.52. Two 50 loci, on 13q33.3 16q23.3, as or data 122 search variants performed test at 11 cohort 827 familial sub-cohort 293 CRC colorectal, gastric, within 1530 controls. One SNP, rs115943733 10q11.21, reached statistical significance (OR = 3.26, p 0.009). Seven 4 had higher OR smaller compared larger cases. results this gave support an increased CRC, cancer. Further studies are needed confirm able use information prevention.

Language: Английский

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