The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target DOI Creative Commons

Min Cheol Hong,

Xu‐Feng Huang, Huiming Zhu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Circular RNA (circRNA) is a new type of non-coding that has gained significant attention in recent years, especially tuberculosis research. Tuberculosis poses major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate research breakthroughs. The role circRNA mycobacterium infection being gradually revealed, highlighting its importance regulating gene expression, immune response, inflammation. Additionally, researchers are interested because potential for early diagnosis as biomarker. This article systematically analyzes existing literature to provide insights into personalized treatment. We also emphasize the need future enhance application prevention control.

Language: Английский

A panel of six immune-related mRNAs as biomarkers for tuberculosis diagnosis DOI Creative Commons

Yutong Wei,

Zilu Wen,

Qinghua Xue

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Objective This study aims to screen common immunological markers of lung tissues and blood for diagnosis tuberculosis (TB). Methods Differentially expressed miRNAs (DEmRs) mRNAs (DEGs) were obtained by whole-transcriptome sequencing profiles on 18F-FDG PET/CT high low metabolic active regions in nine TB patients. Common screened intersecting with DEmRs, four miRNA GEO datasets, their target predicted through the miRTarbase Tarbase databases. Then these intersected DEGs, from samples immune-related genes, construct a miRNA-mRNA interaction network, hub genes identified Cytoscape. The relationship between immune infiltration evaluated using Cibersort. Finally, diagnostic model based Lasso regression analysis was established validated qRT-PCR. Results Five both tissues. Six ( NEDD4 , PLTP RNASEL SEMA7A TAPBP THBS1 ) out. A 30 pairs (TB/health volunteers). AUC 6-mRNA combination 0.79. Conclusion We six as diagnosing tuberculosis.

Language: Английский

Citations

0
The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target DOI Creative Commons

Min Cheol Hong,

Xu‐Feng Huang, Huiming Zhu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Circular RNA (circRNA) is a new type of non-coding that has gained significant attention in recent years, especially tuberculosis research. Tuberculosis poses major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate research breakthroughs. The role circRNA mycobacterium infection being gradually revealed, highlighting its importance regulating gene expression, immune response, inflammation. Additionally, researchers are interested because potential for early diagnosis as biomarker. This article systematically analyzes existing literature to provide insights into personalized treatment. We also emphasize the need future enhance application prevention control.

Language: Английский

Citations

0