Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)
Published: Dec. 20, 2024
Language: Английский
Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(2)
Published: Jan. 1, 2024
Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions
Language: Английский
Citations
16
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 110995 - 110995
Published: April 5, 2024
Language: Английский
Citations
13
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 399, P. 111143 - 111143
Published: July 14, 2024
Language: Английский
Citations
4
Published: Jan. 1, 2025
Language: Английский
Citations
0
Scientia Pharmaceutica, Journal Year: 2025, Volume and Issue: 93(1), P. 12 - 12
Published: Feb. 28, 2025
Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, and current treatments have significant side effects. Cannabidiol (CBD), a compound derived from Cannabis sativa, has demonstrated promising anticancer properties. However, further investigation required to elucidate its underlying molecular mechanisms. Methods: Network pharmacology docking analysis approaches were utilized. Molecular targets CBD CRC-associated genes identified using Swiss Target Prediction, Malacards, DisGeNet databases. Protein–protein interactions analyzed STRING Cytoscape. Ontology enrichment was conducted ShinyGO, gene expression immune infiltration evaluated with UALCAN TISIDB. Results: We found 95 common between CRC targets. Six major (ANXA5, IGF1R, JAK2, MAPK8, MDM2, PARP1) particularly interesting due their high connectivity role in relevant metabolic pathways. The results indicated that interacts favorably these genes, modulating critical pathways such as RAS/MAPK PI3K-AKT/FoxO, which are involved cell proliferation, apoptosis, cycle regulation. ANXA5 JAK2 relevant, they correlated significantly infiltration, suggesting immunoregulation tumor microenvironment. Conclusions: potential modulate key processes through specific core presenting itself possible complementary therapy improve efficacy reduce adverse effects conventional treatments.
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 291 - 291
Published: March 10, 2025
Background/Objectives: Activation of cannabinoid CB1 or CB2 receptors induces the death glial progenitors from chick retina in culture. Here, by using an enriched retinal cell culture, we characterized some mechanisms underlying promoted cannabinoids. Methods and Results: Retinal cultures obtained 8-day-old (E8) embryos maintained for 12–15 days (C12–15) were used. MTT assays revealed that CB1/CB2 agonist WIN 55,212-2 (WIN) decreased viability a time-dependent manner, with concomitant increase extracellular LDH activity, suggesting membrane integrity loss. Cell was also dose-dependently induced cannabidiol (CBD), Δ9-tetrahydrocannabinol (THC), CP55940, another agonist. In contrast to WIN-induced not blocked either antagonist, deleterious effect CBD receptor antagonist SR144528, but PF514273, antagonist. WIN-treated showed cells large vacuoles cytoplasm absent incubated plus 4-phenyl-butyrate (PBA), chemical chaperone. Since cannabinoids phosphorylation eukaryotic initiation factor 2-alfa (eIF2α), these results suggest process endoplasmic reticulum (ER) swelling stress. Incubation 4 h ~five-fold number labeled ROS indicator CM-H2DCFDA. JNK p38 cultures, expressing cleaved-caspase 3 (c-CASP3). The decrease expression c-CASP3 salubrinal, inhibitor eIF2α dephosphorylation. Conclusions: These data induce apoptosis culture promoting production, ER stress, phosphorylation, caspase-3 processing. graphical abstract created at Biorender.com.
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Hepatocellular carcinoma (HCC) is a fatal cancer that often diagnosed at the advanced stages which limits available therapeutic options. The interaction of HGF with c-MET (a receptor tyrosine kinase) results in activation subsequently triggers PI3K/Akt/mTOR axis. Overexpression HCC tissues has been demonstrated to contribute tumor progression and metastasis.
Language: Английский
Citations
3
Biochimie, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Citations
2
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 7, 2024
Hepatitis B virus (HBV) is an enveloped DNA that causes chronic hepatitis (CHB) infection. Annexin, a Ca2+-activated protein, widely expressed in various organs and tissues has potential utility disease diagnosis treatment. However, the relationship between annexin family CHB remains unclear. Clinical samples from patients donors or healthy individuals were collected. Transcriptome sequencing liver HBV-infected cells performed. HepG2.2.15 with full-length HBV genome HepG2-NTCP cell models established. mouse model was constructed adeno-associated utilized. ANXA4 expression elevated during knockdown promoted replication aggravated injury, while overexpression alleviated that. Mechanistically, autophagy pathway activated by deficiency, promoting autophagic degradation of minichromosome maintenance complex component 2 (MCM2). MCM2 inhibition replication, attenuated deficiency-induced injury. Clinically, viral protein negatively correlated levels, high levels (> 8 ng/ml) showed higher sensitivity to interferon therapy. functions as protective factor under attack restrict inhibiting MCM2, thereby alleviating injury suppressing infection process. also enhances Therefore, expected be new target for treatment prognostic evaluation. • both mice. promotes transcription aggravates Autophagy when MCM2. Inhibition activates directly, attenuates The
Language: Английский
Citations
2
Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1943 - 1943
Published: April 24, 2024
Cannabidiol (CBD), a non-psychoactive ingredient extracted from the hemp plant, has shown therapeutic effects in variety of diseases, including anxiety, nervous system disorders, inflammation, and tumors. CBD can exert its antitumor effect by regulating cell cycle, inducing tumor apoptosis autophagy, inhibiting invasion, migration, angiogenesis. This article reviews proposed mechanisms CBD, aiming to provide references for clinical treatment diseases rational use CBD.
Language: Английский
Citations
1