Cited by Aconitine promotes ROS-activated P38/MAPK/Nrf2 pathway to inhibit autophagy and promote myocardial injury

Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells DOI

Na Young Kim,

Dukanya Dukanya,

Gautam Sethi

et al.

Translational Oncology, Journal Year: 2024, Volume and Issue: 49, P. 102101 - 102101

Published: Aug. 18, 2024

Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a-hexahydrocyclopenta[e] [1,2]oxazine (FPPO; BSO-07) on JNK-driven demonstrated human breast (BC) MDA-MB231 MCF-7 cells respectively. BSO-07 imparted significant cytotoxicity BC cells, induced JNK, increased intracellular reactive oxygen species (ROS) levels. It also enhanced the expression apoptosis-associated proteins like PARP, Bax, phosphorylated p53, while decreasing levels Bcl-2, Bcl-xL, Survivin. Furthermore, drug altered linked paraptosis, such as ATF4 CHOP. Treatment with N-acetyl-cysteine (antioxidant) or SP600125 (JNK inhibitor) partly reversed paraptosis. Advanced silico bioinformatics, cheminformatics, density Fourier transform molecular electrostatic potential analysis further that via ROS/JNK pathway

Language: Английский

Citations

Natural products‐induced cancer cell paraptosis DOI

Haitham Al‐Madhagi

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 9866 - 9871

Published: Sept. 12, 2024

Cancer cell can be killed in a programmed way by natural products process known as paraptosis.

Language: Английский

Citations

Cannabis for medicine and food: A benefit vs risk critical appraisal DOI

Murendeni Nethengwe,

Y Maphosa,

BO Ahiante

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 175, P. 15 - 31

Published: Oct. 11, 2024

Language: Английский

Citations

Activation of autophagy, paraptosis, and ferroptosis by micheliolide through modulation of the MAPK signaling pathway in pancreatic and colon tumor cells DOI

Min Yang, Seung Ho Baek, Young Yun Jung

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155654 - 155654

Published: Oct. 11, 2024

Language: Английский

Citations

Paraptosis—A Distinct Pathway to Cell Death DOI

C Kunst,

Deniz Tümen,

Martha Ernst

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11478 - 11478

Published: Oct. 25, 2024

Cell death is a critical biological process necessary for development, tissue maintenance, and defense against diseases. To date, more than 20 forms of cell have been identified, each defined by unique molecular pathways. Understanding these different essential investigating the pathogenesis diseases such as cancer, neurodegenerative disorders, autoimmune conditions developing appropriate therapies. Paraptosis distinct form regulated characterized cytoplasmic vacuolation dilatation cellular organelles like mitochondria endoplasmic reticulum (ER). It several signaling pathways, instance, those associated with ER stress, calcium overload, oxidative specific cascades insulin-like growth factor I receptor (IGF-IR) its downstream pathways comprising mitogen-activated protein kinases (MAPKs) Jun N-terminal kinase (JNK). has observed in diverse contexts, including development stress responses neuronal, retinal, endothelial, muscle cells. The induction paraptosis increasingly important anticancer therapy, it targets non-apoptotic tumor cells, which can be utilized to induce death. This approach enhances treatment efficacy addresses drug resistance, particularly cases where cancer cells are resistant apoptosis. Combining paraptosis-inducing agents traditional therapies holds promise enhancing overcoming suggesting valuable strategy therapy.

Language: Английский

Citations

TMP: A dual modulator of apoptosis and autophagy via SHP-1 regulation in hepatocellular carcinoma DOI

Young Yun Jung, Yejin Hong, Dongwoo Nam

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123316 - 123316

Published: Dec. 1, 2024

Language: Английский

Citations

Elucidating the Molecular Mechanisms of Pterostilbene Against Cervical Cancer Through an Integrated Bioinformatics and Network Pharmacology Approach DOI

Xiang Li,

Dequan Yu,

Qiming Wang

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 396, P. 111058 - 111058

Published: May 17, 2024

Language: Английский

Citations

Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β‐catenin signaling pathway in human breast cancer cells DOI

Bada Yoon,

Basappa Basappa,

Shreeja Basappa

et al.

IUBMB Life, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Autophagy is vital for maintaining cellular homeostasis by breaking down unnecessary organelles and proteins within cells. Its activity varies abnormally in several diseases, including cancer, making it a potential target therapeutic strategies. The Wnt/β‐catenin signaling pathway significantly impacts cancer stabilizing β‐catenin protein promoting the transcription of its genes. Therefore, we aimed to identify candidate substances targeting this pathway. We designed tested thiouracil conjugate, discovering that TTP‐8 had anti‐tumor effects on human breast cell lines MCF‐7 MDA‐MB231. Our findings showed upregulated expression LC3 protein, marker autophagy cells, suggesting might induce autophagy. Further analysis confirmed an increase autophagy‐related proteins, with consistent results obtained from flow cytometry confocal microscopy. Interestingly, induction was even more pronounced MDA‐MB231 cells transfected siRNA. Thus, our research supports idea influences regulation thereby inducing This suggests could serve as novel agent treating cancer.

Language: Английский

Citations

Epigenetic modulation of autophagy pathway by small molecules in colorectal cancer: a systematic review DOI

Mozhdeh Zamani, Farima Safari, Morvarid Siri

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(10)

Published: Oct. 23, 2024

Colorectal cancer (CRC) remains a global health challenge with limited treatment success due to drug resistance. Recent research highlights the potential of small molecules modulate CRC by targeting epigenetics or autophagy pathways. This systematic review explores epigenetic effect on in CRC, aiming identify novel therapeutic strategies. Following PRISMA guidelines, we systematically reviewed 508 studies from PubMed, Scopus, and Web Science databases until August 13, 2023. Eight met inclusion criteria, examining role as modulators (Histone acetylation/deacetylation, DNA methylation/demethylation gene expression regulation miRNAs) influencing pathway CRC. The encompassed vitro animal model vivo studies. Small exhibited diverse effects For instance, panobinostat promoted leading cell death, while aspirin inhibited flux, reducing aspirin-mediated death. modulation various differently affects their anticancer effect, which underscores complexity interventions. Understanding intricate dynamics among molecules, modifications, is crucial for developing targeted Considering dual tumorigenesis tumor suppression, administration these may affect fate response resistance based pathway. Therefore, recognition mechanism contribute deciding how prescribe them better treatment.

Language: Английский

Citations

Aconitine promotes ROS-activated P38/MAPK/Nrf2 pathway to inhibit autophagy and promote myocardial injury DOI

Chunai Yang,

Jinxiao Fu,

Fenshuang Zheng

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 20, 2024

Language: Английский

Citations