Unveiling the Role of MicroRNAs in Breast Cancer Invasion DOI Open Access
Krishna Ahluwalia

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

In 2018, there were significant cancer statistics indicating 8.6 million cases of female cancers and a global count 4.2 cancer-related deaths. Among these, breast emerged as the most common malignancy in females, with approximately twenty percent progressing to metastasis. Unfortunately, metastatic poses formidable challenge for successful treatment, necessitating urgent identification new molecular markers diagnosis prognostic prediction, well development innovative therapeutic approaches. One area focus research involves differentially expressed microRNAs (miRNAs) their role modifying expression genes associated tumor growth. These miRNAs have been extensively studied context cancer. this overview, we summarize recent data regarding specific miRNA profiles observed involvement regulating various invasive processes. processes encompass changes cytoskeletal structure, cell-cell adhesion junctions, interactions between cells extracellular matrix, microenvironments, epithelial-to-mesenchymal transitions, acquisition stem cell-like properties. Additionally, explore epigenetic regulation individual other regulatory genes. Furthermore, examine function isoforms transfer through exosomes, elucidating contribution invasiveness. While ongoing continues unravel full extent functioning cancer, outcomes presented here contribute advancement management offer insights into potential strategies.

Language: Английский

Exploring ferroptosis and miRNAs: implications for cancer modulation and therapy DOI

Mobarakeh Ajam-Hosseini,

Sadegh Babashah

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

1
Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues DOI Creative Commons

Mojdeh Mahmoudian,

Ehsan Razmara, Bashdar Mahmud Hussen

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2021, Volume and Issue: 35(11)

Published: Sept. 15, 2021

Abstract Background Breast cancer (BC) is by far the most common malignancy among women. Epigenetic modulators, microRNAs in particular, may set stages for BC development and its progression. Herein, we aimed to assess diagnostic potentiality of a signature six miRNAs (i.e., hsa‐miR‐25‐3p, ‐29a‐5p, ‐105‐3p, ‐181b1‐5p, ‐335‐5p, ‐339‐5p) adjacent non‐tumor tissues. Methods A pair 50 tumor samples were taken from patients. The expression each candidate miRNA was measured using quantitative reverse transcription PCR. To investigate possible roles their impressions on prognosis, silico tools used. Receiver operating characteristic (ROC) curves performed determine accuracy association with clinicopathological characteristics analyzed. Results Our findings showed upregulation downregulation hsa‐miR‐335‐5p ‐339‐5p compared corresponding Except hsa‐miR‐339‐5p, up‐/down‐regulation associated TNM stages. hsa‐miR‐105‐3p, correlated HER‐2 status. ROC curve analysis that six‐miRNA potential biomarker distinguishing between breast tissue samples. Conclusion We dysregulation novel can be used as diagnosis.

Language: Английский

Citations

44
microRNA Detection via Nanostructured Biochips for Early Cancer Diagnostics DOI Open Access

Sara Martino,

Chiara Tammaro, Gabriella Misso

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7762 - 7762

Published: April 24, 2023

MicroRNA (miRNA) are constituted of approximately 22 nucleotides and play an important role in the regulation many physiological functions diseases. In last 10 years, increasing interest has been recorded studying expression profile miRNAs cancer. Real time-quantitative polymerase chain reaction (RT-qPCR), microarrays, small RNA sequencing represent gold standard techniques used 30 years as detection methods. The advent nanotechnology allowed fabrication nanostructured biosensors which widely exploited diagnostic field. Nanostructured offer advantages: (i) their size allows construction portable, wearable, low-cost products; (ii) large surface–volume ratio enables loading a great number biorecognition elements (e.g., probes, receptors); (iii) direct contact recognition element with analyte increases sensitivity specificity inducing low limits (LOD). this review, miRNA is explored, focusing on electrochemical optical sensing. particular, four types nanomaterials (metallic nanoparticles, graphene oxide, quantum dots, polymers) reported for both strategies aim to show distinct properties applications.

Language: Английский

Citations

19
Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology DOI Creative Commons
Moon Nyeo Park,

Myoungchan Kim,

Soojin Lee

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 501 - 501

Published: April 22, 2025

Reactive oxygen species (ROS) play a dual role in cancer progression, acting as both signaling molecules and drivers of oxidative damage. Emerging evidence highlights the intricate interplay between ROS, microRNAs (miRNAs), exosomes within tumor microenvironment (TME), forming regulatory axis that modulates immune responses, angiogenesis, therapeutic resistance. In particular, stress not only stimulates exosome biogenesis but also influences selective packaging redox-sensitive miRNAs (miR-21, miR-155, miR-210) via RNA-binding proteins such hnRNPA2B1 SYNCRIP. These miRNAs, delivered through exosomes, alter gene expression recipient cells promote tumor-supportive phenotypes M2 macrophage polarization, CD8+ T-cell suppression, endothelial remodeling. This review systematically explores how this ROS–miRNA–exosome orchestrates communication across stromal cell populations under hypoxic inflammatory conditions. Particular emphasis is placed on NADPH oxidases, hypoxia-inducible factors, autophagy-related mechanisms regulating exosomal output. addition, we analyze relevance natural products herbal compounds—such curcumin, resveratrol, ginsenosides—which have demonstrated promising capabilities to modulate ROS levels, miRNA expression, dynamics. We further discuss clinical potential leveraging for therapy, including strategies involving mesenchymal stem cell-derived ferroptosis regulation, miRNA-based modulation. Incorporating insights from spatial transcriptomics single-cell analysis, provides mechanistic foundation development exosome-centered, redox-modulating therapeutics. Ultimately, work aims guide future research drug discovery efforts toward integrating medicine redox biology fight against cancer.

Language: Английский

Citations

0
Identification of Biomarkers Associated With CD8+ T Cells in Coronary Artery Disease and Their Pan-Cancer Analysis DOI Creative Commons
Shijian Zhao,

Yinteng Wu,

Yantao Wei

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 21, 2022

Purpose To identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role the tumor immune microenvironment. Materials Methods CAD-related datasets GSE12288, GSE34198, GSE66360, were downloaded from GEO database. First, GSVA was performed based on GSE12288 dataset. Then WGCNA analysis to most relevant module candidate hub gene for cells, followed by GO KEGG of this module. Secondly, relationship between genes verified using GSE34198 which led identification genes. The cancer analyzed TIMER Methylation DiseaseMeth CAD, pan-cancer, pan-cell lines, pan-normal tissues, correlations In addition, drugs TFs predicted, ceRNA network constructed. Finally, GSEA separately Results CAD shown be response analysis. identified blue as related nine relevance immunity further confirmed Two additional validated three (FBXO7, RAD23A, MKRN1) that significantly correlated cells. we found positively TGCT, THCA, KICH cancers our Moreover, differentially methylated. We also correlation different cancers, cell normal tissues. results all analyses showed a positive them. successfully constructed gene-associated TF-gene networks predicted 11 suggests are multiple processes. Conclusion FBXO7, MKRN1 may act through responses cancer.

Language: Английский

Citations

16
Potential diagnostic and prognostic biomarkers for breast cancer: A compiled review DOI

Kareena Moar,

Anuja Pant,

Vikas Saini

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154893 - 154893

Published: Oct. 20, 2023

Language: Английский

Citations

7
Association of microRNA-21 expression with breast cancer subtypes and its potential as an early biomarker DOI

Sau Har Lee,

Brianna Brianna

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155073 - 155073

Published: Jan. 3, 2024

Language: Английский

Citations

2
Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review DOI Creative Commons
Galo Duque, Carlos Manterola, Támara Otzen

et al.

Clinical Medicine Insights Oncology, Journal Year: 2022, Volume and Issue: 16

Published: Jan. 1, 2022

Background: Breast cancer (BC) is the most common neoplasm in women worldwide. Liquid biopsy (LB) a non-invasive diagnostic technique that allows analysis of biomarkers different body fluids, particularly peripheral blood and also urine, saliva, nipple discharge, volatile respiratory nasal secretions, breast milk, tears. The objective was to analyze available evidence related use obtained by LB for early diagnosis BC. Methods: Articles BC due LB, published between 2010 2022, from databases (WoS, EMBASE, PubMed, SCOPUS) were included. MInCir scale applied articles determine their methodological quality (MQ). Descriptive statistics used, as well determination weighted averages each variable, extracted data. Sensitivity, specificity, area under curve values specific (individual or panels) are described. Results: In this systematic review (SR), 136 met selection criteria, representing 17 709 patients with However, 95.6% case-control studies. 96.3% cases, performed samples. Most based on microRNA (miRNA) analysis. mean MQ score 25/45 points. have been found. Conclusions: through useful mechanism miRNA studied methodology. Our results indicate has high sensitivity specificity BC, especially stages.

Language: Английский

Citations

10
Identification of miR-125a and miR-106b signature as a potential diagnostic biomarker in breast cancer tissues DOI
Soudeh Ghafouri‐Fard, Bashdar Mahmud Hussen, Solat Eslami

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155277 - 155277

Published: March 27, 2024

Language: Английский

Citations

1
Integrated miRNA Signatures: Advancing Breast Cancer Diagnosis and Prognosis DOI Creative Commons
Μαρία Σαμαρά, Eleni Thodou,

Marina Patoulioti

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1352 - 1352

Published: Oct. 24, 2024

Breast cancer ranks first in incidence and second deaths worldwide, presenting alarmingly rising mortality rates. Imaging methodologies and/or invasive biopsies are routinely used for screening detection, although not always with high sensitivity/specificity. MicroRNAs (miRNAs) could serve as diagnostic prognostic biomarkers breast cancer. We have designed a computational approach combining transcriptome profiling, survival analyses, power calculations from 1165 patients carcinoma The Cancer Genome Atlas (TCGA-BRCA). Our strategy yielded two separate miRNA signatures consisting of four up-regulated five down-regulated miRNAs tumors, cumulative strength AUC 0.93 0.92, respectively. provide direct evidence regarding the cancer-specific expression both through multicancer comparison >7000 representing 19 solid types, challenging their potency beyond any current methods. functionally implicated cancer-related processes statistically significant effects on overall lymph-node invasion patients, which underlie strong implication. Collectively, we propose novel significantly elevated resolved tool binary accurate detection other tumors female reproductive system.

Language: Английский

Citations

1