Breast cancer invasion by microRNAs aid

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

In 2018, there were an estimated 8.6 million new cases of cancer in women and 4.2 deaths from worldwide. addition, 20% who are diagnosed with breast will go on to develop metastases. Therefore, is urgent need discover molecular markers for the diagnosis prognostic prediction metastatic illness create novel treatment agents. MicroRNAs (miRNAs) have been studied extensively shown induce numerous alterations expression genes involved carcinogenesis. this review, we compile recent information cancer-specific miRNA profiles their role regulating invasive processes, conjunction cytoskeletal structure, cell-cell adhesion junctions, cell-extracellular matrix interactions, tumor microenvironments, epithelial-to-mesenchymal transitions, cell stem abilities. Finally, discussed isoforms exosome-mediated transfer invasiveness, focused how epigenetic regulation affects individual miRNAs those interact other regulatory genes. While more work needed fully understand cancer, findings presented here help advance disease.

Language: Английский

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Biomarkers in breast cancer liquid biopsies: cell-free microRNAs and extracellular vesicles

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

The prognosis of breast cancer (BC) patients is greatly improved by preemptive diagnosis. Researchers are exploring the possibility liquid biopsy based on circulating microRNAs (c-miRNAs) due to absence accurate biomarkers for diagnosis, prognosis, and, therapy follow up in BC. These c-miRNAs, which may be cell-free or coupled with extracellular vesicles (EVs), offer several benefits over conventional methods (core-biopsy and surgery), including stability biofluids, noninvasive accessibility, expression response pathogenic circumstances. Because their precise vesicle sorting, EV-derived (EV-miRNAs) have recently emerged as a potential new sector use diagnostics. We summarize recent research c-miRNA treatment. also discuss how lack consensus best analyze data collected from these can hinder clinical practice. BACKGROUND

Language: Английский

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MiRNAs Play a Functional Role in the Development of In Situ Breast Carcinoma

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

MicroRNAs (miRNAs) are a kind of tiny RNA that regulates gene expression by snatching up mRNA. may have role in either promoting or inhibiting tumor growth depending on the activity genes they target. Even though DCIS is often misdiagnosed as breast cancer, it be precursor to invasive ductal carcinoma. The preinvasive stage characterized alterations miRNAs and other genetic processes necessary for development DCIS. been shown cancer regulating oncogenic tumor-suppressive pathways. Hormone signaling, cell-cell adhesion, epithelial-to-mesenchymal transition, transforming factor maintenance stem cells, manipulation extracellular matrix all demonstrated influenced Furthermore, exosomal enhance altering microenvironment. In this article, we take look back at linked how play disease. We also briefly review present status miRNA treatment problems encountered so far, well important future prospects research into function with goal therapy

Language: Английский

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In the age of microRNAs, Triple-Negative Breast Cancer

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

The purpose of this article is to provide light on the function microRNAs in triple-negative breast cancer (TNBC). We used search engines like PubMed, ScienceDirect, and Springer get information we needed. Only 197 articles were given a thorough evaluation. chose papers that not only discussed TNBC but also various forms using miRNA profiling and/or analysis. Our in-depth analysis led classification miRNAs into groups which individual member's have important roles via many mechanisms including tumorigenesis, invasion, metastasis. Diagnostics, prognosis, therapy, apoptosis. particularly deadly kind cancer. Thus, new methods are required for correct diagnosis, therapy. In study, compile most recent data help with prognosis. bolster strategy managing TNBC.

Language: Английский

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Unveiling the Role of MicroRNAs in Breast Cancer Invasion

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

In 2018, there were significant cancer statistics indicating 8.6 million cases of female cancers and a global count 4.2 cancer-related deaths. Among these, breast emerged as the most common malignancy in females, with approximately twenty percent progressing to metastasis. Unfortunately, metastatic poses formidable challenge for successful treatment, necessitating urgent identification new molecular markers diagnosis prognostic prediction, well development innovative therapeutic approaches. One area focus research involves differentially expressed microRNAs (miRNAs) their role modifying expression genes associated tumor growth. These miRNAs have been extensively studied context cancer. this overview, we summarize recent data regarding specific miRNA profiles observed involvement regulating various invasive processes. processes encompass changes cytoskeletal structure, cell-cell adhesion junctions, interactions between cells extracellular matrix, microenvironments, epithelial-to-mesenchymal transitions, acquisition stem cell-like properties. Additionally, explore epigenetic regulation individual other regulatory genes. Furthermore, examine function isoforms transfer through exosomes, elucidating contribution invasiveness. While ongoing continues unravel full extent functioning cancer, outcomes presented here contribute advancement management offer insights into potential strategies.

Language: Английский

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