The combined impact of neutrophil-percentage-to-albumin ratio and depressive symptoms on mortality in US arthritis patients: insights from NHANES (2005–2018)

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 6, 2025

Background The neutrophil-to-albumin ratio (NPAR) reflects inflammation and nutritional status, while depression significantly impacts survival in chronic disease patients. This study examines the independent combined effects of NPAR depressive symptoms on all-cause cardiovascular mortality arthritis Methods We analyzed a nationally representative sample people with arthritisaged 40 older from NHANES (2005–2018). assessed were measured by PHQ-9. Weighted Cox regression examined joint associations PHQ-9 (CVD) mortality. Results Our analysis indicated that higher levels lower (PHQ-9 < 10) increased CVD risks In this group, hazard (HR) for was 2.087, similarly elevated risk (HR = 2.614), underscoring NPAR’s predictive strength non-depressed individuals. Among those symptoms, still associated mortality, its impact less marked, highlighting need further research into NPAR-depression interaction. Conclusion identifies as key predictor patients, particularly fewer symptoms. predicts value an nutrition biomarker. Integrating clinical practice could enhance individualized assessment intervention

Language: Английский

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Associations between neutrophil percentage-to-albumin ratio with all-cause and cause-specific mortality among US cancer survivors: evidence from NHANES 2005–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 17, 2025

The neutrophil percentage-to-albumin ratio (NPAR) had been suggested as a potential prognostic biomarker in various health outcomes. However, its association with mortality cancer survivors remains unclear. A total of 3,022 from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 were linked to outcomes Death Index (NDI). Weighted Cox proportional hazards models was conducted investigate between NPAR all-cause, cardiovascular disease (CVD) hazard (HR) 95% confidence interval (CI) calculated. Restricted cubic spline (RCS) used clarify non-linear association. Additionally, analyses for stratification sensitivity performed. During median follow-up 75 months, 790 all-cause deaths occurred, including 244 209 CVD. After adjustment covariates, higher independently associated increased risk (HR = 1.09, CI 1.06-1.13), 1.05, 0.99-1.12), CVD 1.13, 1.06-1.21). RCS revealed U-shaped relationship mortality, thresholds 12.76 13.60, respectively. Below threshold, reduced 0.90, 0.82-0.99; HR 0.87, 0.76-0.99), whereas above significantly 1.14, 1.09-1.18; 1.15, 1.07-1.24). Subgroup confirmed these findings. along linear underscores valuable marker survivors.

Language: Английский

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Predictive role of neutrophil-percentage-albumin ratio (NPAR) in overactive bladder (OAB) in adults in the United States: a cross-sectional study

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: April 18, 2025

There is mounting evidence suggesting a direct connection between inflammatory responses and the pathophysiology of overactive bladder (OAB). However, conventional markers do not directly indicate correlation with OAB. Therefore, our goal was to investigate relationship OAB novel marker, neutrophil percentage-to-plasma-albumin ratio (NPAR). This study included 28,906 participants from 2005-2018 National Health Nutrition Examination Survey (NHANES). Weighted multivariate regression models multiple equations were applied evaluate NPAR Additionally, possibility linear OAB, smoothed curve fitting used. Sensitivity stratified analyses conducted assess robustness results. The final sample size consisted individuals, an overall prevalence 24.6%. Using weighted logistic model adjusting for covariates, we identified strong association (OR 1.074, 95% CI 1.06-1.08). Individuals in highest quartile had 32% greater compared those lowest quartile. Smoothed showed nonlinear effect sizes remained consistent across specific subgroups (P interaction < 0.05). incidence shown positively correlate higher levels this investigation. might be useful affordable biomarker determining who at risk facilitating timely intervention.

Language: Английский

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Association of neutrophil percentage-to-albumin ratio with all-cause and respiratory disease-related mortality in US adults with asthma: results from NHANES 1999-2018

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Background: Systemic inflammation and immune dysregulation may be associated with asthma onset progression. Neutrophil percentage-to-albumin ratio (NPAR) is a novel marker of systemic inflammation. We aimed to investigate the association NPAR all-cause respiratory disease-related mortality in adults through NHANES 1999-2018. Methods:NPAR was calculated by neutrophil percentage (% total white blood cell count) × 100/serum albumin (g/dl). Asthma diagnosed standardized questionnaire. Mortality obtained prospective matching National Death Index. Multivariate Cox proportional hazards regression analysis used explore these associations. Results:A 5042 were included. After median follow-up duration 104 months, 697 participants died, which 101 deaths. In fully adjusted models, significantly positively both (hazard ratios [HR] 1.126 1.194, respectively, p < 0.05). Compared Q1, at Q4 increased (all-cause: HR 2.112, 0.0001; disease-related: 2.595, = 0.013). nonlinearly mortality, an inflection point 13.76. This significant only after point. The effect on more pronounced those <60 years age. Conclusions:Higher disease US asthma. Further exploration prognostic potential underlying mechanisms needed. Clinical trial number Not applicable.

Language: Английский

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A Biomarker-Centric Diagnostic Approach based on Neutrophil Percentage to Albumin Ratio (NPAR) for Diabetic UTIs

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 288 - 295

Published: Nov. 30, 2024

The Neutrophil Percentage to Albumin Ratio (NPAR) was identified as a promising biomarker for identifying inflammation and renal complications in diabetic Urinary Tract Infections (UTIs). Objective: To evaluate the diagnostic potential of NPAR novel diagnosis prognosis UTIs. Methods: current study carried out according PRISMA criteria determine prognostic value (April 2024 June 2024) made on Google Scholar, Science Direct, PubMed with date ranging from 2014 2024. Articles comparing effect non-diabetic UTI-related inflammation, immune cells suppression, comparison classic biomarkers comorbidities damage were taken review. Information available different world areas, such Asia Pacific, Europe, America’s breadth. first search found 162 papers, but 134 remained after duplicates deleted, these screened reviewed, resulting inclusion 15 studies systematic Results: findings demonstrated that has higher reliability diagnosing than traditional biomarkers, especially septic patients hypoalbuminemia. Conclusions: Due reliability, sensitivity specificity NPAR, it evaluating UTI. Its implementation part clinical practice could extend understanding disorder early identification.

Language: Английский

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